Eva Donck^1,*, Sofie Verbeke², Pieter De Visschere³, Valérie Fonteyne⁴, Charles Van Praet¹, Kathia De Man⁵, Nicolaas Lumen¹

Canadian Journal of Urology, Vol.33, No.1, pp. 83-92, 2026, DOI:10.32604/cju.2025.068589 - 28 February 2026

Abstract Objectives: PSMA PET/CT (Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography) offers improved accuracy in detecting lymph node invasion (LNI) in prostate cancer (PC) patients, potentially reducing the need for extended pelvic lymph node dissection (ePLND). This study aims to evaluate a patient-tailored care pathway in which ePLND is performed only in patients with unfavorable intermediate- or high-risk PC who are deemed at risk for LNI based on PSMA PET/CT findings. Methods: In this interventional cohort study, 81 patients were managed according to the new care pathway. ePLND was omitted in cases of negative PSMA PET/CT… More >

Dorian Dikov¹, Maria Koleva^2,*, Kiril Simitchiev³, Anelia Bivolarska⁴, Albena Fakirova⁵, Victoria Sarafian^6,7

Canadian Journal of Urology, Vol.33, No.1, pp. 125-134, 2026, DOI:10.32604/cju.2025.068575 - 28 February 2026

Abstract Background: Chronic inflammation is closely associated with the most common and socially significant prostate conditions, including benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis syndromes. NIH-category IV prostatitis (histologic prostatitis, HP) is defined as asymptomatic chronic inflammation of the prostate. The presence of lymphoid follicles, referred to as tertiary lymphoid structures (TLSs), along with benign lympho-epithelial lesions (BLELs), is among the key histological indicators of immune inflammation and can be assessed relatively easily. This study aimed to quantitatively assess TLSs and BLELs, as well as their relationship with the severity of HP. Methods: We… More >

Kursad Donmez^1,*, Enis Mert Yorulmaz², Enes Candemir², Serkan Ozcan², Osman Kose², Sacit Nuri Gorgel², Yigit Akin²

Canadian Journal of Urology, Vol.33, No.1, pp. 211-219, 2026, DOI:10.32604/cju.2025.068294 - 28 February 2026

Abstract Background: Urologic cancers typically metastasize to common organs, while spread to sites such as the heart, hand, cranial bones, penis, or tonsil is exceedingly rare. The clinical relevance and prognostic impact of these unusual metastases remain unclear. This case series highlights six exceptional cases, providing unique insights to support awareness and management. Case Description: We retrospectively analyzed six cases of patients diagnosed with urologic cancers who developed metastases at uncommon sites. Each case was evaluated based on clinical presentation, imaging findings, histopathological confirmation, treatment course, and outcomes. Relevant literature was reviewed to contextualize findings. Among the… More >

Liang Dong^1,#, Jialu Xin^1,#, Jingyi Zhang², Zheng Liu², Junjun Li^3,*, Xujun Yu^1,*

Canadian Journal of Urology, Vol.33, No.1, pp. 63-74, 2026, DOI:10.32604/cju.2025.068263 - 28 February 2026

Abstract Varicocele (VC) is widely recognized as a prevalent and clinically significant cause of male infertility. However, the comprehensive pathogenic mechanisms underlying VC development and progression remain incompletely understood, creating an important knowledge gap in the field of andrology. This review establishes that VC pathogenesis centers on abnormal vascular remodeling and integrates multiple contributing elements, including anatomical abnormalities, biochemical disturbances, genetic factors, low body mass index (BMI), age, and specific sports habits, while secondary varicoceles are primarily induced by compressive pathologies. Through a systematic synthesis of current evidence and recent advances, this review aims to elucidate More >

Christian Gozzi¹, Bruno Bucca^2,*, Orietta Dalpiaz³, Aldo Brassetti⁴, Luca Matteo Gobbi², Greta Basile², Miroslav Djordjevic^5,6

Canadian Journal of Urology, Vol.33, No.1, pp. 75-82, 2026, DOI:10.32604/cju.2025.068035 - 28 February 2026

Abstract Overview: Surgical management of benign prostatic hyperplasia (BPH) has evolved significantly, incorporating various minimally invasive procedures aimed at reducing morbidity and optimizing patient outcomes. Despite advancements, transurethral approaches continue to pose risks such as urethral strictures and urinary incontinence due to mechanical and thermal stress. To address these limitations, the Suprapubic Transvesical Adenoma Resection of the Prostate (STAR-P) was developed, offering a direct suprapubic route that bypasses the urethra entirely. Recent studies have validated STAR-P as both feasible and safe, emphasizing advantages such as enhanced visualization of the urinary sphincter, minimized urethral trauma, effective hemostasis,… More >

Gianluca Spena¹, Francesco Passaro¹, Achille Aveta¹, Roberto Contieri^1,*, Alessandro Izzo¹, Giuseppe Quarto¹, Giovanni Grimaldi¹, Luigi Castaldo¹, Dario Franzese¹, Raffaele Muscariello¹, Savio Domenico Pandolfo², Antonio Tufano³, Sisto Perdonà¹

Canadian Journal of Urology, Vol.33, No.1, pp. 117-123, 2026, DOI:10.32604/cju.2025.068026 - 28 February 2026

Abstract Background: The Da Vinci Single-Port Robotic System (Da Vinci-SP), introduced by Intuitive (CA, USA) in 2018 in the USA and in 2024 in Europe, integrates advanced features like a flexible camera and articulating instruments. It has garnered significant interest in urology. Our report presents the first described European series of Radical Prostatectomies using the Da Vinci SP at the leading Italian center, Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale” Foundation, detailing the technical differences and challenges faced by experienced multiport robotic surgeons. Methods: Sixteen patients have been enrolled and underwent Single-Port (SP) Robot-Assisted Radical… More >

Marco Di Mitri^1,2,*, Edoardo Collautti^1,2, Cristian Bisanti³, Andrea Zulli¹, Alberto Mantovani¹, Annalisa Di Carmine³, Michelangelo Baldazzi⁴, Roberto Lo Piccolo¹, Riccardo Coletta^1,5, Lorenzo Masieri⁶, Mario Lima³

Canadian Journal of Urology, Vol.33, No.1, pp. 185-192, 2026, DOI:10.32604/cju.2025.067303 - 28 February 2026

Abstract Background: Double blind-ending ureter (DBU) is an extremely rare congenital anomaly involving a duplicated ureter with no connection to the renal pelvis or bladder, making diagnosis difficult. Case Description: A 10-year-old girl presented with recurrent abdominal pain and ultrasound evidence of left hydroureteronephrosis. Magnetic resonance imaging (MRI) and three-dimensional (3D) reconstruction revealed a 30 cm blind-ending ureter. Robotic-assisted excision (Da Vinci Xi) was performed safely, preserving adjacent structures. Histology confirmed a nonfunctional ureteral remnant. Conclusions: DBU is a rare duplication variant. Advanced imaging and robotic surgery are essential for accurate diagnosis and effective, minimally invasive treatment. More >

Marie-Lou Letouche^1,2,*, Aideen Madden^2,3, Mariela Corralles^2,3, Steeve Doizi^2,3, Olivier Traxer^2,3

Canadian Journal of Urology, Vol.33, No.1, pp. 227-232, 2026, DOI:10.32604/cju.2025.067253 - 28 February 2026

Abstract Background: We present a case of two major complications following insertion of a nephrostomy managed in a minimally invasive way. Our case is the first in the literature to describe this minimally invasive treatment technique for colon perforation in a completely asymptomatic patient. Case Description: A 75-year-old female patient with a history of bilateral obstructive uropathy secondary to bilateral radiation-induced ureteric strictures attended for bilateral nephrostomy placement. The patient had a history of endometrial cancer, treated previously by total hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemo-radiotherapy and brachytherapy. Her recovery had been further complicated by the… More >

Léa Bollen^1,*, Stéphane Rysselinck², Jean-Philippe Salmin³, Gilles Dosin⁴

Canadian Journal of Urology, Vol.33, No.1, pp. 221-225, 2026, DOI:10.32604/cju.2025.067192 - 28 February 2026

Abstract Background: Penile augmentation through injectable substances is becoming increasingly common. A growing number of aesthetic clinics are developing penile enlargement procedures using various injectable materials. Although these procedures are now performed in more controlled and medically supervised environments, their long-term outcomes remain poorly understood. The promotion of such medical treatments contributes to an increasing interest among adult males in self-injection as a method to alleviate psychological distress associated with penile size concerns. At the same time, access to injectable substances through unofficial or unregulated sources has become increasingly easy. Tor our knowledge, we report the… More >

Bo Yin^1,#, Xingyu Long^2,#, Zhi Wang¹, Feng Ning¹, Kan Wang², Jun He^1,*

Canadian Journal of Urology, Vol.33, No.1, pp. 201-210, 2026, DOI:10.32604/cju.2025.067189 - 28 February 2026

Abstract Background: Clear cell sarcoma of the kidney (CCSK) is a rare and highly aggressive pediatric renal malignancy with a marked propensity for metastatic spread. Cases of CCSK associated with inferior vena cava (IVC) tumor thrombus (IVCTT) are exceptionally uncommon in the literature. We report a case of CCSK with IVCTT in a 15-month-old male infant. Case Description: We reported a case admitted in May 2020 for a 3-day history of fever and hematuria. Abdominal CT revealed an unevenly enhanced mass and low-density shadows within the IVC. The diagnosis of CCSK was confirmed via needle biopsy. The… More >