Xiaolong Zhu, Feng Chen, Yuntian Chen, Wei Zhu, Xiaoxiao Han*
The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.3, pp. 1-1, 2025, DOI:10.32604/icces.2025.012584
Abstract Human tissues and organs exhibit not only intricate anatomical architectures but also spatially heterogeneous distributions of elastic modulus—for example, between cancellous and cortical bone, across the epidermis, dermis, and subcutaneous layers, and between healthy and fibrotic liver tissues. Conventional biomaterials often fail to replicate such mechanical heterogeneity, thereby limiting their capacity to recreate biomimetic physiological microenvironments essential for applications like tissue regeneration and disease modeling. Meta-biomaterials, artificially engineered through the rational structural design of continuous materials, have emerged as a promising class of materials owing to their highly tunable mechanical and biological properties. These attributes… More >