Guillaume Broc^1,*, Julien Carretier^2,3, Sabrina Rouat⁴, Laure Guittard^5,6, Julien Péron^7,8, Béatrice Fervers^3,9, Laurent Letrilliart^6,10, Philippe Sarnin⁴, Jean-Baptiste Fassier^11,12, Marion Lamort-Bouché^6,10

Psycho-Oncologie, Vol.17, No.3, pp. 167-179, 2023, DOI:10.32604/po.2023.044730

Abstract Aims: Return to work (RTW) after breast cancer is a complex process that questions the individual trajectories of patients and stakeholders. Program planning in this context requires relying on appropriate methods like Intervention Mapping (IM) which encompasses such complexity. The aim of the methodological study is to describe an application of IM for both the design and production of a patient guide supporting RTW after breast cancer. Procedure: According to IM, the guide was co-constructed with a Community Advisory Board (CAB) of stakeholders (patients/associations, health professionals, companies, institutions) after considering other options (interactive website, mobile application). The design was done… More >

Valérie Berger^1,2,*, Hélène Hoarau^1,2, Florence Saillour^3,4

Psycho-Oncologie, Vol.17, No.3, pp. 159-166, 2023, DOI:10.32604/po.2023.044727

Abstract The development of digital platforms is transforming caregiver-patient interactions and the dissemination of knowledge. Obtaining information from the Internet has become a habit for many patients and must be considered by caregivers. Thus, understanding the use of digital tools by patients is a public health issue. The Sav-AQ study aims to understand patterns of use by women with breast cancer and the role of health professionals. Sav-AQ is an exploratory feasibility study with a mixed design, exploring patient and healthcare experience before and after the integration of a specific website into their care pathways. The research is based on the… More >

Charlotte Bauquier^1,2,*, Myriam Pannard^1,2, Léa Baillat^1,2, Maëva Piton^1,2, Chantal Denieul², Isabelle Audouard², Stéphanie Jean-Daubias^2,3, Mouna Mouline², Murielle Sevenne², Annick Gerard², Marie Préau^1,2

Psycho-Oncologie, Vol.17, No.3, pp. 191-194, 2023, DOI:10.32604/po.2023.044552

Abstract Over the last forty years, many methodologies have been initiated within the framework of the participatory approach, the objective of which is to encourage the involvement of citizens in the definition and implementation of projects and policies concerning them. The implementation of these participatory approaches in the field of interventional research in population health reveals several scientific, organizational, inter-individual, and ethical issues that must be discussed. Thus, we propose to present here the fruit of a collective reflection of the members of a research group, composed of patient-researchers and researchers in social psychology, on the implementation of the IMPAQT research… More >

ZHAOXU YAO^*, HAIBIN MA, LIN LIU, QIAN ZHAO, LONGCHAO QIN, XUEYAN REN, CHUANJUN WU, KAILI SUN

BIOCELL, Vol.47, No.9, pp. 1965-1975, 2023, DOI:10.32604/biocell.2023.030796

Abstract Objective: Through integrated bioinformatics analysis, the goal of this work was to find new, characterised N7-methylguanosine modification-related long non-coding RNAs (m7G-lncRNAs) that might be used to predict the prognosis of laryngeal squamous cell carcinoma (LSCC). Methods: The clinical data and LSCC gene expression data for the current investigation were initially retrieved from the TCGA database & sanitised. Then, using co-expression analysis of m7G-associated mRNAs & lncRNAs & differential expression analysis (DEA) among LSCC & normal sample categories, we discovered lncRNAs that were connected to m7G. The prognosis prediction model was built for the training category using univariate & multivariate COX… More >

LINGYAN LV^1,2,#, JING ZHAO^1,2,#, XUAN WANG^1,2, LIUYAN XU^1,2, YINGYI FAN², CHUNHUI WANG³, HONGQIAO FAN^4,5,*, XIAOHUA PEI^5,*

BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

MINGHONG WEI^1,#, CHENG XIAO^1,2,#, JIAN WU^1,3, LIHONG QIN^1,3, HONGLIANG LIU^1,3, YANG CAO^1,*, YUMIN ZHAO^1,3,*

BIOCELL, Vol.47, No.9, pp. 2115-2123, 2023, DOI:10.32604/biocell.2023.030364

Abstract Background: The regulatory genes related to lipid metabolism affect the intramuscular fat (IMF) content and improve meat quality traits. Mediator Complex Subunit 4 (MED4), a vitamin D receptor protein, affects vitamin D, livestock growth, carcass traits, and triglyceride deposition. However, the physiological function of the MED4 gene on bovine adipocyte differentiation remains unknown. Methods: This study explored the function of the MED4 gene in preadipocyte differentiation in Chinese Red Steppe cattle. The overexpression plasmid and the interference sequences of the MED4 gene were constructed to detect the effects of the MED4 gene on adipogenesis and biomakers using quantitative polymerase chain… More >

YANG GU^1,#,*, MINGGUANG BI^2,#, DEHUI CHEN³, NING NI⁴, JIANMING CHEN^1,*

BIOCELL, Vol.47, No.9, pp. 2069-2080, 2023, DOI:10.32604/biocell.2023.029989

Abstract Background: The underlying mechanism of sciatic nerve injury (SNI) is a common motor functional disorder, necessitates further research. Methods: A rat model of SNI was established, with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure. An oxygen-glucose deprivation model was employed to simulate in vitro SNI in PC12 cells. Following data acquisition and quality control, differentially expressed proteins (DEPs) in each model were identified through differential analysis, and enrichment analysis was used to explore the potential functions and pathways… More >

GAOZHONG LI, FUXIN LI, NING WEI, QING JIA^*

BIOCELL, Vol.47, No.9, pp. 2081-2099, 2023, DOI:10.32604/biocell.2023.029986

Abstract Background: This study was aimed at identifying natural killer (NK) cell-related genes to design a risk prognosis model for the accurate evaluation of gastric cancer (GC) prognosis. Methods: We obtained NK cell-related genes from various databases, followed by Cox regression analysis and molecular typing to identify prognostic genes. Various immune algorithms and enrichment analyses were used to investigate the mutations, immune status, and pathway variations among different genotypes. The key prognostic genes were assessed using the least absolute shrinkage and selection operator (Lasso) regression analysis and univariate Cox regression analysis. Thereafter, the risk score (RS) prognosis model was constructed based… More > Graphic Abstract

DANIELLA M. ADAMS¹, KALIE F. BECKERS¹, JULIET P. FLANAGAN¹, VIVIANE C. L. GOMES^1,#, CHIN-CHI LIU¹, JENNY L. SONES^1,2,*

BIOCELL, Vol.47, No.9, pp. 2051-2058, 2023, DOI:10.32604/biocell.2023.029644

Abstract Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks of PE, are observed spontaneously in BPH/5 mice. Similar to obese preeclamptic women, BPH/5 mice have higher visceral white adipose tissue (WAT) and circulating leptin. We hypothesized that attenuation of maternal obesity and serum leptin in pregnant BPH/5 mice will improve fetoplacental development by decreasing hypoxia markers and leptin expression at the maternal-fetal interface. Methods: To test this hypothesis, BPH/5 mice were fed ad libitum (lib) and pair-fed (PF) to C57 ad lib controls beginning… More >

CHUNYANG XU^1,#, CAIYUN YANG^1,#, JINSONG ZHANG², XIAOHUA PAN³, JUN WANG⁴, LEI JIANG², HONGWEI YE^1,*, BO CHEN^1,*

BIOCELL, Vol.47, No.9, pp. 2027-2035, 2023, DOI:10.32604/biocell.2023.029277

Abstract Background: The lung is one of the primary target organs of hydrogen sulfide (H₂S), as exposure to H₂S can cause acute lung injury (ALI) and pulmonary edema. Dexamethasone (Dex) exerts a protective effect on ALI caused by exposure to toxic gases and is commonly used in the clinic; however, the underlying mechanisms remain elusive, and the dose is unclear. Methods: In vivo experiments: divided C57BL6 mice into 6 groups at random, 12 in each group. The mice were exposed to H₂S for 3 h and 5 or 50 mg/kg Dex pretreated before exposure, sacrificed 12 h later. The morphological changes… More >