Qianwen Hou¹, Aike Qiao^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 37-37, 2019, DOI:10.32604/mcb.2019.05717

Abstract In order to explore the effect of aortic sinus diameter on aortic valve opening and closing performance in the case that aortic valve itself has no obvious disease and aortic root expands continuously. In this study, 20 groups of aortic root models with different aortic sinus and root diameters were constructed according to the size of clinical surgical guidance to simulate the possible expansion of aortic root at the later stage of operation. The valve sinus diameter DS were set to 32 mm, 36 mm, 40 mm and 44 mm, the aortic root diameter DA… More >

Aike Qiao^1,*, Honghui Zhang¹, Jun Xia¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 35-35, 2019, DOI:10.32604/mcb.2019.05715

Abstract In order to improve the calculation accuracy of computed tomography angiography-derived fractional flow reserve (FFR_CT), a mathematical model for setting the patient-specific flow boundary condition was proposed, in which some independent physiological parameters, such as myocardial mass, diastolic blood pressure, heart rate and vessel volume were considered. This model was employed to simulate hemodynamics in sixteen patients with coronary stenosis. The results of FFR_CT demonstrated good consistency with invasively measured FFR. The diagnostic accuracy of FFR_CT was 85%. The proposed model offers a new approach to improve the accuracy of FFR_CT, as well as promotes the clinical More >

Lu Huang¹, Juhui Qiu^1,*, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 33-34, 2019, DOI:10.32604/mcb.2019.05714

Abstract Oscillatory shear stress (OSS) is one of the major risk factors related to endothelial (EC) dysfunction, which contributes to atherosclerosis. Our previous study indicated that inhibitor of DNA binding 1 (Id1) plays vital role in the regulation of OSS mediated EC function related to atherosclerosis. However, the initiation mechanism during this process remains to be elucidated. Ten-eleven Translocation protein 1 alternative isoform (Tet1s) is a newly reported protein that may have function in adult tissue. Here, we investigate the role of Tet1s in regulating OSS mediated endothelial dysfunction and its underlying mechanism. First, physical interaction… More >

Yue Feng¹, Youjun Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 31-32, 2019, DOI:10.32604/mcb.2019.05713

Abstract Coronary atherosclerotic heart disease, or coronary heart disease for short, is a heart disease caused by atherosclerotic lesions of coronary arteries, resulting in stenosis, spasm and live obstruction, leading to myocardial ischemia, hypoxia and even necrosis, and is the most common type of organ lesions caused by atherosclerosis. Coronary computed tomograph angiography (CCTA) has been the most effective method for examining coronary heart disease, but this method can only be judged from the morphology. It has been shown that when the coronary stenosis rate is as high as 70%, only 32% of blood vessels can… More >

Zhiyong Li^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 29-30, 2019, DOI:10.32604/mcb.2019.06308

Abstract In this article, we summarize our previous work in imaging-based computational modelling and simulation of the interaction between blood flow and atherosclerotic plaque. We also discussed our recent developments in multiphysical modelling of plaque progression and destabilization. Significance and translation of the modelling study to clinical practice are discussed in order to better assess plaque vulnerability and accurately predict a possible rupture. More >

Peng Wu^1,*, Qi Gao², Runjie Wei³, Hongping Wang³, Lizhong Wang³

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 27-28, 2019, DOI:10.32604/mcb.2019.05711

Abstract Cardiovascular diseases are the leading cause of human deaths worldwide. Traditional diagnostic tools of cardiovascular diseases are either based on 2D static medical images, or invasive, bringing troubles to both patients and doctors. Our team is committed to the development of image-based non-invasive diagnostic system for cardiovascular diseases. We have made progress mainly in the following areas: 1) 4D flow technology for heart and large blood vessels. According to MRI 4D Flow data, three-dimensional velocity fields within blood vessels were constructed. Divergence-fee smoothing (DFS) was proposed to eliminate the high frequency noise in the hemodynamic… More >

Fuyou Liang^1,*, Tianqi Wang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 25-26, 2019, DOI:10.32604/mcb.2019.05710

Abstract Hepatic venous pressure gradient (HVPG) measurement has been increasingly accepted as a useful means for indirectly measuring portal venous pressure in patients with portal hypertension (PHT) caused by chronic liver diseases. Despite the existence of numerous studies addressing the clinical utility of HVPG measurement, it is as yet unclear how the accuracy of measured HVPG as a surrogate of portal pressure gradient (PPG) is influenced by the pathological status of the hepatic circulation that not only changes with the progression of liver disease but also differs considerably among patients. In addition, it remains unclear whether… More >

Haibo Jia^1,*, Bo Yu¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 23-24, 2019, DOI:10.32604/mcb.2019.05708

Abstract Coronary angiography is the traditional standard imaging modality for visual evaluation of coronary anatomy and guidance of percutaneous coronary interventions (PCI). However, the 2-dimensional lumenogram cannot depict the arterial vessel per se and plaque characteristics, or directly assess the stenting result. Intracoronary imaging by means of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) provides valuable incremental information that can be used clinically to optimize stent implantation and thereby minimize stent-related problems. Beyond guidance of stent selection and optimisation, imaging provides critical insights into the pathophysiology of acute coronary syndrome (ACS), greater clarity when confronted… More >

Zhuangyuan Meng¹, Tao Ma², Shengzhang Wang^1,*, Zhihui Dong^2,*, Weiguo Fu²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 19-21, 2019, DOI:10.32604/mcb.2019.05706

Abstract This article has no abstract. More >

Stéphane Avril^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 17-18, 2019, DOI:10.32604/mcb.2019.05705

Abstract The fluid mechanics community has been interested for many years in hemodynamics. More recently, significant endeavours of the solid mechanics community have permitted to establish constitutive equations and to achieve stress analyses in arterial lesions (atheromatous plaque in coronary or carotid arteries, aneurysms of the aorta). The mechanical properties of blood vessels have often been characterized ex vivo, but medical imaging, including MRI, now allows non-intrusive identifications in vivo. The spatial heterogeneity of these mechanical properties, even at the macroscopic scale, remains poorly explored despite its undeniable interest in understanding the mechanisms of remodeling and degeneration of… More >