Mengyue Wang¹, Runze Zhao¹, Fan Feng¹, Tingting Xia^1,*, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 130-130, 2019, DOI:10.32604/mcb.2019.07154

Abstract Hepatocellular carcinoma (HCC) is the third most common cancer in the world. Previous studies have shown that hard matrix promotes the proliferation of liver tumor cells. However, the role of matrix stiffness on hepatic cancer stem cells (HCSCs) is still unclear. Three-dimensional hydrogels with different stiffness were used to mimic the normal liver tissue (4kPa) and cancerous liver tissue (26kPa) stiffness. The proliferation, stemness and invasion properties of HCSCs under 3D different stiffness were detected. METHOD: HSCSs were screened and cultured by enrichment method, and the effect of matrix stiffness on HCSCs was studied by three-dimensional culture of HCSCs in… More >

Yun Peng¹, Guoan Li^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 128-129, 2019, DOI:10.32604/mcb.2019.07392

Abstract This article has no abstract. More >

Qiuping Liu¹, Guanbin Song^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6, 25, 54 kPa were produced… More >

Akisue Kuramoto^1,*, Hitoshi Kimura², Norio Inou²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 126-126, 2019, DOI:10.32604/mcb.2019.08127

Abstract Comfortable bedding is usually designed subjectively because of the difficulty in performing a quantitative evaluation. This paper proposes a quantitative evaluation method of comfortableness of beddings. The bedding shape determining how comfortable an individual may feel in using it depends on the body shape and normal posture of individuals. The internal physical load is expected to relate to the comfortableness of bedding. However, only a few quantitative discussions exist on the relation between the comfortableness of bedding and physical load. This study proposes a new evaluation method of physical load in a relaxed posture. The strain energy of muscles and… More >

Lulu Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 125-125, 2019, DOI:10.32604/mcb.2019.07101

Abstract Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor… More >

Meng-Wei Lin¹, Feng Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 123-124, 2019, DOI:10.32604/mcb.2019.07343

Abstract This article has no abstract. More >

Chien-Chi Liu¹, Sai-Wei Yang^1,*, Tsui-Fen Yang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 120-122, 2019, DOI:10.32604/mcb.2019.07150

Abstract Scoliosis is the most common type of spinal deformity of the young adults, and women outnumber men about 10:1 [1], in which the Adolescent Idiopathic Scoliosis (AIS) is up to 90% for ages 10 to 16year-old teenagers [2]. Studies revealed that due to the 3-dimensional musculoskeletal deformities, the AIS subjects to the dynamic postural instability including vestibular and proprioception disorders [3-5]. Dynamic postural Balance is monitored by integration of cortical modulation and somatosensory response [6], and the either motor or sensory impairment lead to balance dysfunction as well as pathologic gait. Studies revealed that the biomechanics functional foot orthotics can… More >

Yao Guo¹, Yijiang Song², Yu Zhang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 119-119, 2019, DOI:10.32604/mcb.2019.07134

Abstract Osteoarthritis (OA), with its high disability and mortality rate, is the most common arthritis throughout the world [1]. Exposure of articular cartilage to excessive mechanical stress is deeply involved in the pathogenesis of osteoarthritis (OA) [2,3]. However, the mechanism of how mechanical stress causes cartilage degradation is not clear yet. Here we report that bioinformatics-based integrative analyses can assist in the study of mechanisms modulated by mechanical stress within OA pathology, and we reveal that B-cell Translocation Gene 2 (BTG2) can be a mechanosensitive gene involved in OA development. We obtained OA-associated differentially expressed genes from human and rat datasets… More >

Lianhong Pan¹, Li Yang^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 118-118, 2019, DOI:10.32604/mcb.2019.07133

Abstract Osteoarthritis (OA) is a chronic joint bone disease which always leads to the dysfunction and disability of arthritis. Synovial inflammation plays an important role in the pathogenesis and progress of OA which can secrete large amounts of inflammatory cytokines. There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Icariin, a traditional Chinese herbal medicine, is the major pharmacological active component of herb Epimedium. This study we investigated the influence of icariin on the main cells in synovium-osteoarthritis fibroblast-like synoviocytes (OA-FLSs). The OA-FLSs were… More >

Zhongzheng Wang^1,2, Fei Tian³, Shaobai Wang³, Songtao Ai², Tsung-Yuan Tsai^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 116-117, 2019, DOI:10.32604/mcb.2019.07690

Abstract This article has no abstract. More >