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  • Open Access

    ARTICLE

    Genome-Wide Identification, Evolution and Expression Analyses of GA2ox Gene Family in Brassica napus L.

    Yanhua Li1,#, Hualei Huang1,#, Youming Shi1, Shuqin Huang1, Tao Liu1, Changming Xiao1, Xiaoqing Tian2, Ping Zhao1, Xiaoyan Dai3, Taocui Huang1,*, Yan Zhou1,*

    Phyton-International Journal of Experimental Botany, Vol., , DOI:10.32604/phyton.2022.023928

    Abstract Gibberellin 2-oxidases (GA2ox) are important enzymes that maintain the balance of bioactive GAs in plants. GA2ox genes have been identified and characterized in many plants, but these genes were not investigated in Brassica napus. Here, we identified 31 GA2ox genes in B. napus and 15 of these BnGA2ox genes were distributed in the A and C subgenomes. Subcellular localization predictions suggested that all BnGA2ox proteins were localized in the cytoplasm, and gene structure analysis showed that the BnGA2ox genes contained 2–4 exons. Phylogenetic analysis indicated that BnGA2ox family proteins in monocotyledons and dicotyledons can be divided into four groups, including… More >

  • Open Access

    ARTICLE

    Angiogenic Gene PTK2 is a Potential Biomarker of Gestational Diabetes Mellitus and is Significantly Associated with Breast Cancer Immune Infiltration

    Xuelian Du1,#, Hao Shi2,#, Haiyan Liu1, Linghua Zhou1, Anqun Xie1, Jufang Guo1,*

    Oncologie, Vol., , DOI:10.32604/oncologie.2022.026248

    Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship between protein tyrosine kinase… More >

  • Open Access

    REVIEW

    The Emerging Role of Lymphocyte Activation Gene 3 in the Cancer Immunotherapy

    Xue Cui1,2, Min Peng2, Honglei Chen1,*

    Oncologie, Vol., , DOI:10.32604/oncologie.2022.023641

    Abstract The emergence of tumor immunotherapy, especially immune checkpoint inhibitors (ICIs), has brought new life to cancer treatment, and ICIs can effectively treat various tumors. Among the immune anti-cancer therapies, PD-1 is undoubtedly the hot target after CTLA-4, but due to the ineffectiveness of PD-1 in treating certain tumors, researchers have shifted their focus to other combination targets, such as LAG-3, TIM3, IDO-1, etc. One of these promising targets is LAG-3, a target with multiple clinical trials, which has increasingly shown to be an inhibitory co-receptor that plays a vital role in autoimmunity, cancer immunity, and anti-infection immunity. Immune combination therapy… More >

  • Open Access

    REVIEW

    Research Progress on Structure and Bioactivity of Longan Polysaccharide

    Xiaolong Ji1,#, Shuli Zhang1,#, Xueyuan Jin2, Xin Yuan1, Siqi Zhang1, Xudan Guo3,*, Fengcheng Shi4,*, Yanqi Liu1

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.025844

    Abstract Longan originates from southern China and has high nutritional and health value. Recent phytochemistry and pharmacology studies have shown that polysaccharides are a main bioactive component of longan. Longan polysaccharides possess antioxidant, anti-aging, anti-tumor, immunomodulatory, and other bioactivities. Hot-water extraction, ethanol precipitation, and ultrasonic extraction are generally used to extract water-soluble longan polysaccharides. However, the relationship between the structure and bioactivity of longan polysaccharides remains unclear, requiring further investigation. The aim of this review is to evaluate the current literature focusing on the extraction, purification, structural characterization, and biological activity of longan polysaccharides. We believe that this review would provide… More >

  • Open Access

    ARTICLE

    New Perspective to Isogeometric Analysis: Solving Isogeometric Analysis Problem by Fitting Load Function

    Jingwen Ren1, Hongwei Lin1,2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2023.025983

    Abstract Isogeometric analysis (IGA) is introduced to establish the direct link between computer-aided design and analysis. It is commonly implemented by Galerkin formulations (isogeometric Galerkin, IGA-G) through the use of nonuniform rational B-splines (NURBS) basis functions for geometric design and analysis. Another promising approach, isogeometric collocation (IGA-C), working directly with the strong form of the partial differential equation (PDE) over the physical domain defined by NURBS geometry, calculates the derivatives of the numerical solution at the chosen collocation points. In a typical IGA, the knot vector of the NURBS numerical solution is only determined by the physical domain. A new perspective… More >

  • Open Access

    REVIEW

    A Survey of Convolutional Neural Network in Breast Cancer

    Ziquan Zhu, Shui-Hua Wang, Yu-Dong Zhang*

    CMES-Computer Modeling in Engineering & Sciences, Vol., , DOI:10.32604/cmes.2023.025484

    Abstract Problems: For people all over the world, cancer is one of the most feared diseases. Cancer is one of the major obstacles to improving life expectancy in countries around the world and one of the biggest causes of death before the age of 70 in 112 countries. Among all kinds of cancers, breast cancer is the most common cancer for women. The data showed that female breast cancer had become one of the most common cancers. Aims: A large number of clinical trials have proved that if breast cancer is diagnosed at an early stage, it could give patients more… More >

  • Open Access

    ARTICLE

    A 3D Geometry Model of Vocal Tract Based on Smart Internet of Things

    Ming Li1, Kuntharrgyal Khysru2, Haiqiang Shi2,*, Qiang Fang3,*, Jinrong Hu4, Yun Chen5

    Computer Systems Science and Engineering, Vol., , DOI:10.32604/csse.2023.034687

    Abstract The Internet of Things (IoT) plays an essential role in the current and future generations of information, network, and communication development and applications. This research focuses on vocal tract visualization and modeling, which are critical issues in realizing inner vocal tract animation. That is applied in many fields, such as speech training, speech therapy, speech analysis and other speech production-related applications. This work constructed a geometric model by observation of Magnetic Resonance Imaging data, providing a new method to annotate and construct 3D vocal tract organs. The proposed method has two advantages compared with previous methods. Firstly it has a… More >

  • Open Access

    ARTICLE

    Hydrolysable Chestnut Tannin Extract Chemical Complexity in Its Reactions for Non-Isocyanate Polyurethanes (NIPU) Foams

    Elham Azadeh1, Antonio Pizzi1,2,*, Christine Gerardin-Charbonnier1,*, Philippe Gerardin1

    Journal of Renewable Materials, Vol., , DOI:10.32604/jrm.2023.027651

    Abstract Non-isocyanate polyurethane (NIPU) foams from a commercial hydrolysable tannin extract, chestnut wood tannin extract, have been prepared to determine what chemical species and products are taking part in the reactions involved. This method is based on two main steps: the reaction with dimethyl carbonate and the formation of urethane bonds by further reaction of the carbonated tannin with a diamine-like hexamethylene diamine. The hydroxyl groups on the tannin polyphenols and on the carbohydrates intimately linked with it and part of a hydrolysable tannin are the groups involved in these reactions. The carbohydrate skeleton of the hydrolysable tannin is also able… More >

  • Open Access

    ARTICLE

    Experimental Investigation on Fracture Performance of Short Basalt Fiber Bundle Reinforced Concrete

    Jinggan Shao1,2, Jiao Ma1, Renlong Liu1, Ye Liu3, Pu Zhang1,*, Yi Tang4, Yunjun Huang2

    Structural Durability & Health Monitoring, Vol., , DOI:10.32604/sdhm.2022.015097

    Abstract In this paper, a notched three-point bending test is used to study the fracture performance of the short basalt fiber bundle reinforced concrete (SBFBRC). To compare and analyze the enhancement effect of different diameters and different content of basalt fiber bundles on the fracture performance of concrete, some groups are set up, and the P-CMOD curves of each group of specimens are measured, and the fracture toughness and fracture energy of each control group are calculated. The fracture toughness and fracture energy are two important fracture performance parameters to study the effect and law of the new basalt fiber bundles… More >

  • Open Access

    ARTICLE

    DNA polymerase θ (POLQ): A druggable DNA polymerase for homologous recombination-deficient cancer cells

    MERAN KESHAWA EDIRIWEERA*

    BIOCELL, Vol., , DOI: 10.32604/biocell.2023.025747

    Abstract Irregularities in the DNA repair pathways are frequently observed in cancer. Dysregulated DNA repair pathways support growth advantages to tumor cells. DNA polymerase-theta (POLQ) is an error-prone DNA polymerase involved in double-strand break repair through microhomology-mediated end joining (MMEJ). POLQ also mediates translesion DNA synthesis and it is largely not expressed in normal cells. POLQ is overexpressed in a range of cancer cells, including homologous recombination (HR) deficient cancer cells. In HR deficient cells, MMEJ is crucial as a backup DNA repair pathway, indicating the indispensable role of POLQ-mediated MMEJ in HR deficient cancer cells. In addition, POLQ is synthetic… More >

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