Attila Szendroi1, Gabor Speer2, Adam Tabak2,3, Janos P. Kosa2, Peter Nyírády1, Attila Majoros1, Imre Romics1, Peter Lakatos2
Canadian Journal of Urology, Vol.18, No.3, pp. 5710-5716, 2011
Abstract Introduction: Prostate cancer is the second leading cause of cancer death among men in developed countries. Estrogen receptor-alpha (ER-α), vitamin D receptor (VDR), and the calcium-sensing receptor (CaSR), partly through their effects on calcium levels are implicated in the proliferation and carcinogenesis in the prostate gland. VDR, ER-α and CaSR genes show polymorphisms in humans that appear to have clinical significance in many pathological conditions, such as prostate cancer. Our aim was to evaluate the role of ER-α (PvuII, XbaI), VDR (BsmI) and CaSR (A986S) gene polymorphisms and serum calcium levels in the pathogenesis of prostate… More >