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  • Open Access

    ARTICLE

    Decreased invasion ability of hypotaurine synthesis deficient glioma cells was partially due to hypomethylation of Wnt5a promoter

    Hong TIAN1, 2, Peiyu CONG3, Ruiqun QI4, Xinghua GAO5, Xin LIU6, Hongsheng LIU7, Fengping SHAN1,*

    BIOCELL, Vol.41, No.1, pp. 27-32, 2017, DOI:10.32604/biocell.2017.41.027

    Abstract Glioma is one of the lethal central nervous system tumors. The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues, resulting in inevitable recurrence after surgery operation. Gliomas do not metastasize, so to prevent the residual tumor from proliferating or invading is a key challenge. Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’ activities. Using a hypotaurine synthesis deficient U251 cell line, we proved that the cells invasion ability was impaired. Gene expression profile analysis exhibited that knocking down one of… More >

  • Open Access

    REVIEW

    An integrated analysis of mRNA-miRNA transcriptome data revealed hub regulatory networks in three genitourinary cancers

    Mian LIU1, Xumeng ZHANG2, *

    BIOCELL, Vol.41, No.1, pp. 19-26, 2017, DOI:10.32604/biocell.2017.41.019

    Abstract Bladder, kidney, prostate and testicular carcinoma are the top four genitourinary cancers in China. Here we analyzed mRNA and miRNA expression profiles of carcinomas of the bladder (TCC), kidney (ccRCC) and testis (TGCT) to uncover their specific regulatory mechanisms. The gene expression profiles of GSE31617 were downloaded from GEO database, which contained 27 samples, including 10 TCC, 7 TGCT and 10 ccRCC. Specific up- and downregulated differentially expressed genes (DEGs) and differentially expressed microRNAs (DEmiRNAs) of each cancer were selected and target genes of DEmiRNAs were predicted. Gene interaction network of the shared genes and… More >

  • Open Access

    ARTICLE

    Antifungal activity of various essential oils against Saccharomyces cerevisiae depends on disruption of cell membrane integrity

    HATİCE BÜŞRA KONUK, BENGÜ ERGÜDEN*

    BIOCELL, Vol.41, No.1, pp. 13-18, 2017, DOI:10.32604/biocell.2017.41.013

    Abstract Antifungal activity and mode of action of nine essential oils (EOs) against S. cerevisiae cells were examined. Antifungal effects of commercial lemon peel, orange peel, tea tree, turpentine, rosemary, peppermint, thyme, oregano and clove oils were determined through Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC) and inhibition zone measurements. The most effective oil was turpentine oil. Orange peel, thyme and oregano oils were also effective, according to MIC and MFC. Inhibition zone measurements, also revealed oregano, orange peel, thyme, turpentine and clove oils as most efficient ones. Later, membrane damage of yeast cells was studied… More >

  • Open Access

    ARTICLE

    Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus

    Maximiliano GIRAUD-BILLOUD1, 2*, Fernando EZQUER2, Javiera BAHAMONDE2, Marcelo EZQUER2

    BIOCELL, Vol.41, No.1, pp. 1-12, 2017, DOI:10.32604/biocell.2017.41.001

    Abstract A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy, but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus (T1DM). We used eight-weekold male C57BL/6 mice divided into two groups; one of them received the vehicle (control group), while the other received the vehicle + 200 mg/kg streptozotocin (T1DM). Ten weeks after the injection, we evaluated plasma insulin, enzymuria, urinary vitamin D-binding protein (VDBP), tubulointerstitial fibrosis and proximal… More >

  • Open Access

    ARTICLE

    Condition Monitoring of Roller Bearing by K-Star Classifier and K-Nearest Neighborhood Classifier Using Sound Signal.

    Rahul Kumar Sharma*1, V. Sugumaran1, Hemantha Kumar2, Amarnath M3

    Structural Durability & Health Monitoring, Vol.11, No.1, pp. 1-16, 2017, DOI:10.3970/sdhm.2017.012.001

    Abstract Most of the machineries in small or large scale industry have rotating element supported by bearings for rigid support and accurate movement. For proper functioning of machinery, condition monitoring of the bearing is very important. In present study sound signal is used to continuously monitor bearing health as sound signals of rotating machineries carry dynamic information of components. There are numerous studies in literature that are reporting superiority of vibration signal of bearing fault diagnosis. However, there are very few studies done using sound signal. The cost associated with condition monitoring using sound signal (Microphone)… More >

  • Open Access

    ARTICLE

    Numerical Simulation of Thermosolutal Convective Transitions in a Very Narrow Porous Annulus under the Influence of Lewis Number

    A. Ja1, A. Cheddadi1

    FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.4, pp. 235-249, 2017, DOI:10.3970/fdmp.2017.013.235

    Abstract This paper reports on the natural convection within a very narrow horizontal annular cavity filled with a porous medium saturated by a binary fluid. The main objective of this study is the identification of the effect of Lewis number on the flow structure and on the heat and mass transfer rates, in a cavity of very small radius ratio R=1.05, in the case of equal buoyancy forces (N=1), for a Rayleigh number Ra=50. The dimensionless governing equations were solved by the centered Finite Difference method using the ADI scheme. Several multicellular flows appear during the variation of More >

  • Open Access

    ARTICLE

    Computational Investigation of Droplets Behaviour inside Passive Microfluidic Oscillator

    Tawfiq Chekifi1, *, Brahim Dennai2, Rachid Khelfaoui2

    FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.3, pp. 173-187, 2017, DOI:10.3970/fdmp.2017.013.173

    Abstract Recently, modeling immiscible fluids such as oil and water have been a classical research topic. Droplet-based microfluidics presents a unique platform for mixing, reaction, separation, dispersion of drops and many other functions. In this paper, we suggest a numerical CFD study of microfluidic oscillator with two different lengths of feedback loop. In order to produce simultaneous droplets of gasoil on water, a typical geometry that includes double T-junction is connected to the fluidic oscillator. Droplets production is computed by volume-of-fluid method (VOF). Flow oscillations of droplets were triggered by the Coanda effect of jet flow. More >

  • Open Access

    ARTICLE

    Rotational Motion of Micropolar Fluid Spheroid in Concentric Spheroidal Container

    M. Krishna Prasad1, G. Manpreet Kaur1

    FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.2, pp. 107-125, 2017, DOI:10.3970/fdmp.2017.013.107

    Abstract The slow steady rotation of a micropolar fluid spheroid whose shape deviates slightly from that of a sphere in concentric spheroidal container filled with Newtonian viscous fluid is studied analytically. The boundary conditions used are the continuity of velocity and stress components, and spin vorticity relation. The torque and wall correction factor exerted on the micropolar fluid spheroid is obtained. The dependence of wall correction factor on the micropolarity parameter, spin parameter, viscosity ratio and deformation parameter is studied numerically and its variation is presented graphically. In the limiting cases, the torque acting on solid More >

  • Open Access

    ARTICLE

    A Controlled Conditions of Dynamic Cold Storage Using Nano fluid as PCM

    Bin Liu1, Zhaodan Yang1, Yahui Wang1, Rachid Bennacer1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.13, No.1, pp. 37-47, 2017, DOI:10.3970/fdmp.2017.013.037

    Abstract The dynamic thermal history of storage product system is related to the insulation and also to the inertia. Use a new porous media doped with nanofluid PCM to improve the system efficiency. The analysis of the porous sponge thickness with 8 mm, 16 mm and 20 mm, the integrated nanofluids with 0.1%, 0.15% and 0.2%, the mass of the PCM and the initial temperature of the stored product with -1°C, 4°C, 12°C is achieved in order to underline the advantages of the new saturated porous media (sponges) with the phase change material (PCM) /Al2O3-H2O nanofluid. The… More >

  • Open Access

    ARTICLE

    Effect of Cellulose Nanocrystals on Fire, Thermal and Mechanical Behavior of N,N’-Diallylphenylphosphoricdiamide Modified Poly(lactic acid)

    Weijun Yang1†, Xiaomin Zhao2†, Elena Fortunati1, Franco Dominici1, Jose M. Kenny1, Debora Puglia1*, De-Yi Wang2*

    Journal of Renewable Materials, Vol.5, No.5, pp. 423-434, 2017, DOI:10.7569/JRM.2017.634146

    Abstract Presented herein is a deep investigation of the fire, mechanical and thermal performances of poly(lactic acid) (PLA)-based nanocomposites, which were obtained by combining cellulose nanocrystals (CNC) with various contents of N,N’-diallyl-phenylphosphoricdiamide (P-AA) via a two-steps masterbatch melt extrusion process (glycidyl methacrylate grafting on PLA and CNC premixing with PLA). Results have shown that the value of the limiting oxygen index (LOI) increased to 28.8% and a V-0 rating in UL94 test was obtained when 2 wt% of P-AA was added in the presence of cellulose nanocrystals (3 wt%). The incorporation of CNC induced a decrease More >

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