Yu-Ning Liu1, Yun-Li Peng1, Lei Liu1, Teng-Yun Wu1, Yi Zhang1, Yong-Jie Lian1, Yuan-Yuan Yang1, Keith W. Kelley2, Chun-Lei Jiang1, Yun-Xia Wang1
European Cytokine Network, Vol.26, No.1, pp. 15-25, 2015, DOI:10.1684/ecn.2015.0362
Abstract Depression is often preceded by exposure to stressful life events. Chronic stress causes perturbations
in the immune system, and up-regulates production of proinflammatory cytokines, which has been proposed to be
associated with the pathogenesis of clinical depression. However, the potential mechanisms by which stress-induced
proinflammatory cytokines lead to the development of depression are not well understood. Here, we sought to
screen the main proinflammatory cytokines and the potential mechanisms linking inflammation to depression-like
behavior during unpredictable, chronic, mild stress (UCMS), in vivo. Mice were allocated into four groups in each
separate experiment: saline-control, saline-UCMS, drug-control… More >