Mark D. Tyson¹, Paul E. Andrews¹, David A. Etzioni², Robert G. Ferrigni¹, Mitchell R. Humphreys¹, Scott K. Swanson¹, Erik P. Castle¹

Canadian Journal of Urology, Vol.20, No.2, pp. 6702-6706, 2013

Abstract Introduction: To evaluate the influence of marriage on the survival outcomes of men diagnosed with prostate cancer.
Materials and methods: We examined 115,922 prostate cancer cases reported to the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2003. Multivariate Cox regression techniques were used to study the relationship of marital status and prostate cancer-specific and overall mortality.
Results: Married men comprised 78% of the cohort (n = 91,490), while unmarried men (single, divorced, widowed, and separated) comprised 22% of the cohort (n = 24,432). Married men were younger (66.4 versus 67.8 years, p < 0.0001), more… More >

Carlos H. Martinez¹, Andrew K. Williams¹, Joseph L. Chin¹, Larry Stitt², Jonathan I. Izawa¹

Canadian Journal of Urology, Vol.20, No.2, pp. 6696-6701, 2013

Abstract Introduction: Clinical variables with more accuracy to predict biologically insignificant prostate cancer are needed. We evaluated the combination of transrectal ultrasound-guided biopsy of the prostate (TRUSBx) pathologic and radiologic findings in their ability to predict the biologic potential of each prostate cancer.
Materials and methods: A total of 1043 consecutive patients who underwent TRUSBx were reviewed. Using pathologic criteria, patients with prostate cancer (n = 529) and those treated with radical prostatectomy (RP) (n = 147) were grouped as: “insignificant” (Gleason score ≤ 6, prostate-specific antigen (PSA) density ≤ 0.15 ng/mL, tumor in ≤ 50% of any… More >

James Lin, Michael Whalen, Dara Holder, Gregory Hruby, G. Joel DeCastro, James McKiernan

Canadian Journal of Urology, Vol.20, No.2, pp. 6690-6695, 2013

Abstract Introduction: We examined the effects of neoadjuvant chemotherapy (NC) in the treatment of muscle invasive urothelial carcinoma of the bladder in those with mixed histology (MH) versus those with pure urothelial carcinoma (UC).
Materials and methods: Between 2000 and 2012, 195 patients were identified with clinical stage T2–T4, N0–Nx, M0–Mx UCB who had either NC (± radical cystectomy) (n = 63) or radical cystectomy (RC) alone (n = 132). Tumors were classified as either pure UC or MH. Endpoints included downstaging to pT0 and overall survival. Multivariable Cox regression and the Kaplan-Meier method were used to estimate… More >

Susan S. Garfield¹, Meghan B. Gavaghan¹, Shannon O. Armstrong¹, J. Stephen Jones²

Canadian Journal of Urology, Vol.20, No.2, pp. 6682-6689, 2013

Abstract Introduction: Several studies, including the recently published phase III study by Stenzl and colleagues, have demonstrated that hexaminolevulinate hydrochloride, when used with blue light fluorescence cystoscopy, improves detection of non-muscle invasive bladder tumors compared to white light cystoscopy and transurethral resection of bladder tumors (TURB) alone.
Materials and methods: The objective of this study was to conduct a detailed assessment of the cost-effectiveness of using hexaminolevulinate hydrochloride with blue light cystoscopy as an adjunct to white light versus white light cystoscopy alone at the time of initial TURB in the United States. A probabilistic decision tree model, More >

Graham Sommer¹, Donna Bouley², Harcharan Gill³, Bruce Daniel¹, Kim Butts Pauly¹, Chris Diederich⁴

Canadian Journal of Urology, Vol.20, No.2, pp. 6672-6681, 2013

Abstract Introduction: There is currently a great deal of interest in the possible use of focal therapies for prostate cancer, since such treatments offer the prospect for control or cure of the primary disease with minimal side effects. Many forms of thermal therapy have been proposed for focal ablation of prostate cancer, including laser, high intensity ultrasound and cryotherapy. This review will demonstrate the important roles that magnetic resonance imaging (MRI) guidance can offer to such focal ablation, focusing on the use of high intensity ultrasonic applicators as an example of one promising technique.
Materials and methods: Transurethral… More >

Imre Romics

Canadian Journal of Urology, Vol.20, No.2, pp. 6669-6671, 2013

Abstract This article has no abstract. More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.20, No.2, pp. 6668-6668, 2013

Abstract This article has no abstract. More >

Jay D. Raman

Canadian Journal of Urology, Vol.20, No.3, pp. 6815-6815, 2013

Abstract This article has no abstract. More >

Christopher E. Bayne¹, William A. Davis², Christopher P. Rothstein³, Jason D. Engel¹

Canadian Journal of Urology, Vol.20, No.3, pp. 6811-6814, 2013

Abstract Transrectal ultrasound guided biopsy (TRUSB) of the prostate directly contaminates the prostate with rectal flora. Patients commonly receive fluoroquinolone (FQ) antibiotics to prevent infection. Infectious complications following TRUSB are increasing. The most common offending organism is Escherichia coli (E. coli), with isolates of this bacteria showing growing resistance to FQs. We present to our knowledge the first reported case of seminal vesicle abscess formation after TRUSB. The abscess was initially not seen on computed tomography and eventually treated with percutaneous drainage by a transgluteal approach. We review literature on infectious complications following TRUSB with implications More >

Vladimir Ruzhynsky, Paul Whelan

Canadian Journal of Urology, Vol.20, No.3, pp. 6808-6810, 2013

Abstract Gonadotropin releasing hormone (GnRH) antagonists, such as degarelix, are emerging as an androgen deprivation therapy primary agents in a treatment of advanced prostate cancer. The role of GnRH antagonists in management of lower urinary tract symptoms associated with prostate cancer has not been clearly established. In this report, we describe the case of a patient with locally advanced prostate cancer who presented with symptoms of urinary retention and renal failure. The use of degarelix in this patient led to a rapid reduction in the prostate-specific antigen level; however, obstructive symptoms persisted despite the use of More >