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  • The characterization of transmembrane protein 59-like (TMEM59L) reveals its role in the regulating the level of the GDI protein family
  • Abstract The characterization and functions of transmembrane protein 59-like (TMEM59L), a type I transmembrane protein, are not clearly understood until now. Some TMEM59L and fluorescent fusion proteins constructs were transfected in cell lines and liposomes, and their localization was observed. The effects of protein constructs were studied by fluorescence microscopy and western blotting. This study reports a novel function of human TMEM59L (hTMEM59L) related to the expression and location of some proteins. In addition, we report two novel splice variants of human TMEM59L (hTMEM59L). The localization of mutants of this protein, lacking a middle region, and a C-terminal deletion, markedly differed…
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  • Pharmacotherapeutics and molecular docking studies of alpha-synuclein modulators as promising therapeutics for Parkinson’s disease
  • Abstract Parkinson’s disease (PD) is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral midbrain. It is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the brain. To date, only a few Food and Drug Administration (FDA) approved drugs are available on the market for the treatment of PD. Nonetheless, these drugs show parasympathomimetic related adverse events and remarkably higher toxicity; hence, it is important to find more efficacious molecules to treat PD. In our study, We chosen 22 natural compounds as…
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  • Mitochondria are an important target of photobiomodulation in cardiomyocytes
  • Abstract Photobiomodulation (PBM) has been shown to delay the pathological process of heart failure, but the exact mechanism of action is not clear. Mitochondria occupy one-third of the volume of mammalian cardiomyocytes (CMs) and are central transport stations for CM energy metabolism. Therefore, in this study, we explored the regulatory effects of 630 nm light-emitting diodes (LED-Red) on the mitochondria of CMs. The results show that LED-Red-based PBM promotes adenosine triphosphate (ATP) synthesis by upregulating the expression of glycolipid metabolizing enzymes. Correspondingly, there was an improvement in the activity of succinate dehydrogenase (SDH), a key enzyme in the mitochondrial electron transport…
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  • Effect of Peroxiredoxin 1 on the biological function of airway epithelial cells and epithelial-mesenchymal transition
  • Abstract Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the effect of PRDX1 on the EMT of airway epithelial cells stimulated with lipopolysaccharide (LPS) and transforming growth factor-beta 1 (TGF-β1). PRDX1 overexpression significantly increased the proliferation and migration of human bronchial epithelial (BEAS-2B) cells, reduced cell apoptosis (p < 0.01), and induced EMT and collagen deposition by upregulating the expression of the matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin and twist proteins and inhibiting E-cadherin expression (p < 0.05). PRDX1 overexpression promoted TGF-β1-mediated inhibition of…
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  • Elevated Temperature Properties of Bamboo Shaving Reinforced Geopolymer Composites
  • Abstract Geopolymer is a new alternative cement binder to produce concrete. In the present study, a novel geopolymer composites containing bamboo shaving (0–2 wt.%) were fabricated and exposed to the temperatures of 200°C, 400°C, 600°C and 800°C. Physical properties, micro-structure, and mechanical strengths of the geopolymer composites were evaluated before and after heating in order to understand their thermal properties, which are essential for the use as building materials. As the temperature rises, the drying shrinkage and apparent porosity of the composites increase, while the compressive and bending strengths decrease. At the temperature range of 200°C–800°C, the residual compressive strength rates of…
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  • Study on Mechanical Properties and Action Mechanism of Leather Industrial Sludge Aggregate Baking-Free Bricks
  • Abstract Taking an industrial sludge and its preparation of sludge wrap shell aggregates (WSAs) instead of sand to prepare baking-free brick as the research object, the development law of mechanical properties and the influence mechanism of macro and micro characteristic parameters of the bricks under different sludge and WSAs replacement rates were studied through the macroscopic mechanical properties test, with the help of nuclear magnetic resonance (NMR), transmission electron microscopy-energy spectrum and other testing technology and pores and cracks analysis system (PCAS) software. The results showed that the compressive strength of each sample decreased with the increase of sludge content. When…
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  • Fabrication and Modification Strategies of Metal Halide Perovskite Absorbers
  • Abstract Due to the long carrier lifetime, high carrier mobility, and high absorption coefficient of perovskite materials, the power conversion efficiency (PCE) of perovskite solar cells (PSCs) has increased from 3.8% in 2009 to 25.7% in 2021, which have already surpassed the PCE of thin-film solar cells and closes to the efficiency of Si-based photovoltaics (26.7%). Therefore, PSCs have become a promising clean energy technology for commercialization. However, the low defect formation energy of perovskite leads to a higher defect density than other conventional photovoltaic materials. It results in severe non-radiative recombination, limiting its further development and the commercialization. In this…
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  • Synthesis and Antioxidant Activity of (E) ω-Formylcamphene-Based Thiazole Hydrazone Derivatives
  • Abstract (E) ω-formylcamphene was synthesized from α-pinene, the main component of turpentine, and then reacted with thiosemicarbazide to obtain (E) ω-formylcamphene thiosemicarbazide 3, which was reacted with 14 α-bromoacetophenone compounds to obtain 14 (E) ω-formylcamphene thiazole hydrazone compounds 5a5n; the yields were all above 80%. The structures of the target compounds were characterized by IR, 1H-NMR, 13C-NMR, and HR-MS analyses. Then, 500, 250, 125, 62.5, and 31.25 mg/L drug solutions were prepared. Free radical scavenging experiments of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2-bis (3-ethyl-benzothiazole-6-sulfonic acid) diammonium salt (ABTS) were carried out with Trolox and L-ascorbic acid as the control samples. The scavenging…
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  • Shear Behaviors of Steel-Plate Connections for Timber-Concrete Composite Beams with Prefabricated Concrete Slabs
  • Abstract To promote the development of timber-concrete composite (TCC) structures, it is necessary to propose the assembly-type connections with high assembly efficiency and shear performances. This article presented the experimental results of the innovative steel-plate connections for TCC beams using prefabricated concrete slabs. The steel-plate connections consisted of the screws and the steel-plates. The steel-plates were partly embedded in the concrete slabs. The concrete slabs and the timber beams were connected by screws through the steel-plates. The parameters researched in this article included screw number, angle steel as the reinforcement for anchoring, and shallow notches on the timber surface to restrict…
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  • Microwave Drying of Scots Pine Lumber: Structure Changes, Its Effect on Liquid Permeability
  • Abstract Microwave (MW) drying method was adopted to enhance the liquid permeability of Scots pine lumber. Structure changes were characterized by stereoscope microscope, scanned electron microscope (SEM) and transmission electron microscope (TEM) examination. Pore parameters before and after MW treatment were detected by mercury intrusion porosimetry (MIP) method, and the effect of structure changes on liquid permeability were analyzed. As stereoscope microscope, SEM and TEM examination results shown, macro and micro checks mainly developed at intercellcular of tracheids, intercellular of ray parenchyma and tracheid, while these checks extend main along the radial-longitudinal plane. Pit border destruction, aspirated pits’ orus translocation and…
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