R. Choo1, V. Do1, L. Sugar2, L. Klotz2, E. Bahk1, E. Hong1, C. Danjoux1, G. Morton1, G. DeBoer1
Canadian Journal of Urology, Vol.11, No.1, pp. 2118-2124, 2004
Abstract Objective: To examine the change of histologic grade of untreated, low to intermediate grade, clinically localized prostate cancer over time on repeat prostate biopsy.
Methods and materials: In a prospective single-arm cohort study, patients were managed with observation alone unless they met pre-defined criteria of disease progression (PSA, clinical or histologic progression). Sixty-seven (54%) of a total of 123 eligible patients underwent follow-up prostate biopsy. Median time to the follow-up biopsy was 22 months (range: 7-60).
Results: On the follow-up biopsy, Gleason score was unchanged in 20 patients (30%), upgraded in 19 (28%), and downgraded in 27 (40%).… More >