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  • Open Access

    ARTICLE

    20(R)-ginsenoside Rg3, a product of high-efficiency thermal deglycosylation of ginsenoside Rd, exerts protective effects against scrotal heat-induced spermatogenic damage in mice

    WEI LIU1,#, ZI WANG1,2,#, JING LENG1, HENG WEI1, SHEN REN1,2, XIAOJIE GONG3, CHEN CHEN4, YINGPING WANG1,2, RUI ZHANG1,2,*, WEI LI1,2,*

    BIOCELL, Vol.44, No.4, pp. 655-669, 2020, DOI:10.32604/biocell.2020.013202

    Abstract Heat stress (HS) reaction can lead to serious physiological dysfunction associated with cardiovascular and various organ diseases. Ginsenoside Rg3 (G-Rg3) is a representative component of ginseng rare saponin and can protect against multiple organs, also used as functional food to adjust the balance of the human body, but the therapeutic effect and molecular mechanism of G-Rg3 on male diseases under HS are underexplored. The aim of the present study, G-Rg3 was prepared through the efficient conversion of ginsenoside Rd and investigate the contribution of G-Rg3 to testicular injury induced exposure to HS. All mice were… More >

  • Open Access

    ARTICLE

    Ginkgo paste improves tinea corporis in a guinea pig model

    LIHUA CAO1, MINGSAN MIAO1,*, YAN ZHENG2, HUIYAUN HUANG2, RUI ZHANG2, DANDAN LIU2

    BIOCELL, Vol.44, No.4, pp. 649-653, 2020, DOI:10.32604/biocell.2020.05093

    Abstract To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model. The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains. And then, high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals. The symptom, tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed. High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom (P < 0.01), increased negative rate of strain culture (P < 0.01), and improved pathological changes of tinea More >

  • Open Access

    ARTICLE

    Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancer progression

    FANGHAO SUN1, WENCHAO ZHAO1, LIANSHENG ZHANG2, HONGGUI MA1, JIAN ZHOU1, YOUGAN CHEN1, JIANQUAN HOU1,*

    BIOCELL, Vol.44, No.4, pp. 639-647, 2020, DOI:10.32604/biocell.2020.013053

    Abstract Recent studies suggested that LIM and SH3 protein 1 (LASP-1) is a promising therapeutic target for renal cell cancer (RCC). This study aimed to explore the role of LASP-1 in RCC. For this purpose, LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis. Cell proliferation, migration, invasion, and gene expression were detected by CCK-8 assay, Transwell assay, and Western blot analysis. The results showed that LASP-1 was highly expressed in RCC, and its expression level,t was positively correlated with lymph node metastasis and tumor, nodes, and metastases (TNM) stage. The knockdown More >

  • Open Access

    ARTICLE

    MiR-4262 regulates differentiation and osteogenesis of human periodontal stem cells by targeting suppressor of cytokine signaling 4

    ZIMING WEI1,2, YARONG WANG3, MINGYUAN DU1,4, MINJIE LI2, HONG HE1,4,*

    BIOCELL, Vol.44, No.4, pp. 631-638, 2020, DOI:10.32604/biocell.2020.010596

    Abstract Periodontitis, as a chronic inflammatory disease, remains unsolved, and the pathogenesis of this disease has not been fully elucidated. In this study, the effect of miR-4262 was investigated in tumor necrosis factor-α (TNF-α) induced human periodontal stem cells (hPDLSCs) for the first time. The gene expression involved in this study was determined using polymerase chain reaction (PCR), the expressions of relevant proteins were determined by western blot analysis, and the levels of IL-1β, IL-6, and MCP-1 were estimated by enzyme-linked immunosorbent assay (ELISA) assay. The luciferase reporter assay was performed for verification of the target More >

  • Open Access

    ARTICLE

    Decreased CD10-positive granulocytes for the differential diagnosis of myelodysplastic syndrome

    JIYU WANG#, HUIPING WANG#, YING PAN, QIANSHAN TAO, ZHIMIN ZHAI*

    BIOCELL, Vol.44, No.4, pp. 607-611, 2020, DOI:10.32604/biocell.2020.010947

    Abstract Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid neoplasms, and a large number of patients are difficult to diagnose and classify by blood and bone marrow examination. As a surface marker of granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients. However, whether it can be used for differential diagnosis of MDS and other hematological diseases remains inconclusive. To explore the value of CD10 for differential diagnosis of MDS, 60 newly diagnosed MDS, 20 aplastic anemia (AA) patients, and 35 iron-deficient anemia (IDA) patients were selected for… More >

  • Open Access

    ARTICLE

    Expression profiling of immune cells in systemic lupus erythematosus by single-cell RNA sequencing

    XIANLIANG HOU1,2,3,#, DONGE TANG1,#, FENGPING ZHENG1,#, MINGLIN OU3, YONG XU1, HUIXUAN XU1, XIAOPING HONG4, XINZHOU ZHANG1, WEIER DAI5, DONGZHOU LIU4,*, YONG DAI1,*

    BIOCELL, Vol.44, No.4, pp. 559-582, 2020, DOI:10.32604/biocell.2020.011022

    Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by abnormal cellular and humoral immune responses and excessive autoantibody production. The precise pathologic mechanism of SLE remains elusive. The advent of single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the molecular differences of cell populations at the single-cell level. We used scRNA-seq to profile the transcriptomes of peripheral blood mononuclear cells from an SLE patient compared with a healthy control (HC). A total of 16,021 cells were analyzed and partitioned into 12 distinct clusters. The marker genes of each cluster and the four major… More >

  • Open Access

    REVIEW

    Functions of ULK1 in autophagy and non-autophagy pathways and its implications in human physiology and disease

    LINNA TAN1,2, YUYONG TAN1,2, DELIANG LIU1,2,*

    BIOCELL, Vol.44, No.4, pp. 535-543, 2020, DOI:10.32604/biocell.2020.09171

    Abstract ULK1 (unc-51 like autophagy activating kinase 1), a mammalian serine/threonine kinase, is a key component of autophagy initiation complex and helps to induce all types of autophagy. Canonical autophagy is a process in which, through the interactions of a series of autophagy-related proteins, damaged organelles or misfolded proteins are engulfed by autophagosomes and then merged with lysosomes to be degraded. Thus, canonical autophagy is an important constituent part of the cellular “quality control.” Besides, accumulating evidence indicates that ULK1 exerts autophagy-independent effects in a cell-specific manner. For example, ULK1 facilitates neurite elongation through the regulation More >

  • Open Access

    ARTICLE

    A Novel Single Switch High Gain DC-DC Converter Topology for Renewable Energy Systems

    G. Indira Kishore1, M. Premkumar1,*, Ramesh Kumar Tripathi2, Chandra Sekhar Nalamati2

    Energy Engineering, Vol.118, No.2, pp. 199-209, 2021, DOI:10.32604/EE.2021.014079

    Abstract Renewable energy with sources such as photovoltaic (PV) or fuel cells can be utilized for the generation of electrical power. But these sources generate fewer voltage values and therefore require high gain converters to match with DC bus voltage in microgrids. These high gain converters can be implemented with switched capacitors to meet the required DC bus voltage. Switched capacitors operate in a series and parallel combination during switching operation and produce high static gain, limits reverse voltage that appears across the components. A novel converter is proposed that satisfies all the features such as More >

  • Open Access

    ARTICLE

    An Analysis of the Operation Mechanism of Chemical Industry Park Ecosystem Based on Theory of Ecological Organization

    Bilin Xu, Mei Han*

    Energy Engineering, Vol.118, No.2, pp. 323-339, 2021, DOI:10.32604/EE.2021.013384

    Abstract Based on the theory of ecological organization, this paper analyzes the operation mechanism of chemical industry park (CIP) ecosystem by means of dynamic simulation. The research shows that the CIP ecosystem is a complex ecological system whose operation mechanism includes two levels, namely individual enterprises and ecosystem. At the level of individual enterprise, there are competition, symbiosis, invasion and other interactions between enterprises in the CIP ecosystem. Through the pre-determined judgment of the competition effect coefficient and the symbiosis effect coefficient, we calculate how the enterprises influence each other, and then generate their respective operation More >

  • Open Access

    ARTICLE

    Performance Assessment of Heat Exchangers for Process Heat Integration

    Fenwicks Shombe Musonye1,*, Hiram Ndiritu2, Robert Kinyua3

    Energy Engineering, Vol.118, No.2, pp. 211-224, 2021, DOI:10.32604/EE.2021.013890

    Abstract Pinch Analysis is an attractive solution for reduction of thermal energy costs in thermo-chemical industries. In this approach, maximum internally recoverable heat is determined and a heat exchange network is designed to meet the recovery targets. The thermal performance of a heat exchanger over its lifetime is however a concern to industries. Thermal performance of a heat exchanger is affected by many factors which include the physical properties of the shell and tube materials, and the chemical properties of the heat transfer fluid. In this study, thermal performance of shell and tube heat exchangers designed… More >

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