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  • Open Access


    An extract of Hypericum perforatum induces wound healing through inhibitions of Ca2+ mobilizations, mitochondrial oxidative stress and cell death in epithelial cells: Involvement of TRPM2 channels

    Fuat USLUSOY1, Mustafa NAZIROĞLU2,3,*

    BIOCELL, Vol.43, No.4, pp. 271-283, 2019, DOI:10.32604/biocell.2019.08333

    Abstract The wound is induced by several mechanical and metabolic factors. In the etiology of the wound recovery, excessive oxidative stress, calcium ion (Ca2+) influx, and apoptosis have important roles. Ca2+-permeable TRPM2 channel is activated by oxidative stress. Protective roles of Hypericum perforatum extract (HP) on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were recently reported. The potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular oxidative toxicity in the renal epithelium (MPK) cells. The cells were divided into three groups as control, wound, and wound + HP treatment… More >

  • Open Access


    Relationship of multidrug-resistant gene and extended-spectrum carbapenem-resistance in Staphylococcus aureus

    Yuan LI1, Yonghyun LEE2, Yielhea SEO3, Youjin HWANG1, 2, *

    BIOCELL, Vol.43, No.4, pp. 263-269, 2019, DOI:10.32604/biocell.2019.07664

    Abstract The aim of this study was to determine the relationship between phenotypic antimicrobial susceptibility patterns and extended-spectrum, carbapenem-resistance genes. A total of 109 clinical Staphilococcus aureus strains were subjected to 19 antimicrobial susceptibility tests. Resistance to methicillin (mecA), penicillin (blaTEM), and tetracycline (tetM) was detected. We compared the presence of the blaTEM genes with extended-spectrum, carbapenem-related genes and identified the types of SCCmec genes. Of 109 clinical S. aureus strains, 62 (56.88%) had methicillin resistance and 60 strains carried mecA. The prevalence of blaTEM and tetM genes was 81.65% and 37.61%, respectively. The most predominant SCCmec type was SCCmec type… More >

  • Open Access


    Overview of genetic causes of recurrent miscarriage and the diagnostic approach

    Tarek A ATIA

    BIOCELL, Vol.43, No.4, pp. 253-262, 2019, DOI:10.32604/biocell.2019.08180

    Abstract Recurring miscarriage (RM) is a frustrating reproductive complication with variable etiology. Numerous genetic defects have been known to play a crucial role in the etiology of RM. Chromosomal abnormalities are frequently detected, while other genetic defects cannot be diagnosed through routine research, such as cryptic chromosomal anomalies, single nucleotide polymorphism, single-gene defect, and gene copy number variation. Diagnostic laboratories have recently used variable advanced techniques to detect potential genetic abnormalities in couples with RM and/or in products of conception. Here we aim to summarize the known genetic causes of RM, with a focus on the new diagnostic techniques. Knowledge of… More >

  • Open Access


    Retrieval, reporting and methodological characteristics for systematic reviews/meta-analyses of animal models: a meta-epidemiological study

    Shuzhen SHI1, 2, Ming LIU1, 2, Wenjuan MA1, 2, Ya GAO1, 2, Long GE3, Xiping SHEN3, Jiarui WU4, Junhua ZHANG5, *, Jinhui TIAN1, 2, *

    BIOCELL, Vol.43, No.4, pp. 233-251, 2019, DOI:10.32604/biocell.2019.07624

    Abstract The study aimed to analyze the reporting and methodological quality of systematic reviews (SRs)/metaanalyses (MAs) of animal models to provide references for later studies and avoid the waste of medical resources. EMBASE and MEDLINE databases were searched from inception to November 2017, with no language restriction. Two reviewers selected inclusion dependently and extracted the basic characteristics. Review Manager 5.3, stata 12.0, and SPSS 21 software were used to conduct analyses. A total of 46 SRs/MAs were included. The results showed that the English databases with high retrieval frequency are PubMed/MEDLINE, EMBASE, and Web of Science. 67.31% (31/46) of the articles… More >

  • Open Access


    Shadow Detection and Removal From Photo-Realistic Synthetic Urban Image Using Deep Learning

    Hee-Jin Yoon1, Kang-Jik Kim1, Jun-Chul Chun1,*

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 459-472, 2020, DOI:10.32604/cmc.2020.08799

    Abstract Recently, virtual reality technology that can interact with various data is used for urban design and analysis. Reality, one of the most important elements in virtual reality technology, means visual expression so that a person can experience threedimensional space like reality. To obtain this realism, real-world data are used in the various fields. For example, in order to increase the realism of 3D modeled building textures real aerial images are utilized in 3D modelling. However, the aerial image captured during the day can be shadowed by the sun and it can cause the distortion or deterioration of image. To resolve… More >

  • Open Access


    Complexity Effective Frequency and Sidelink Synchronization Algorithm for LTE Device-to-Device Communication Systems

    Yong-An Jung1, Min-Goo Kang2, Young-Hwan You1, *

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 443-458, 2020, DOI:10.32604/cmc.2020.08777

    Abstract Device-to-device (D2D) communication is considered as a major challenge in the long term evolution (LTE) network wherein devices directly communicate with each other. One of the key challenges in D2D sidelink is reliable and reduced-complexity synchronization. To address this issue, a computationally efficient sequential detection scheme for integer carrier frequency offset and sidelink identity is proposed in the LTED2D system. To perform the frequency offset detection without retrieving the sidelink identity, the conjugate relation between two primary sidelink synchronization sequences is exploited, which facilitates the detection tasks of frequency offset and sidelink identity to be decoupled. It is demonstrated from… More >

  • Open Access


    The Effect of Initial Defects on Overall Mechanical Properties of Concrete Material

    Yunfa Zhang1, Xiaozhou Xia1, *, Zhenjie Wu1, Qing Zhang1

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 413-442, 2020, DOI:10.32604/cmc.2020.04660

    Abstract Considering the fact that the initial defects, like the imperfect interfacial transition zones (ITZ) and the micro voids in mortar matrix, weaken the mechanical properties of concrete, this study develops corresponding constitutive models for ITZ and matrix, and simulates the concrete failure with finite element methods. Specifically, an elastic-damage traction-separation model for ITZ is constructed, and an anisotropic plastic-damage model distinguishing the strength-difference under tension and compression for mortar matrix is proposed as well. In this anisotropic plastic-damage model, the weakening effect of micro voids is reflected by introducing initial isotropic damage, the distinct characteristic of tension and compression which… More >

  • Open Access


    A Convolution-Based System for Malicious URLs Detection

    Chaochao Luo1, Shen Su2, *, Yanbin Sun2, Qingji Tan3, Meng Han4, Zhihong Tian2, *

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 399-411, 2020, DOI:10.32604/cmc.2020.06507

    Abstract Since the web service is essential in daily lives, cyber security becomes more and more important in this digital world. Malicious Uniform Resource Locator (URL) is a common and serious threat to cybersecurity. It hosts unsolicited content and lure unsuspecting users to become victim of scams, such as theft of private information, monetary loss, and malware installation. Thus, it is imperative to detect such threats. However, traditional approaches for malicious URLs detection that based on the blacklists are easy to be bypassed and lack the ability to detect newly generated malicious URLs. In this paper, we propose a novel malicious… More >

  • Open Access


    An OpenFlow-Based Load Balancing Strategy in SDN

    Xiaojun Shi1, Yangyang Li2, *, Haiyong Xie2, 3, Tengfei Yang2, Linchao Zhang2, Panyu Liu4, Heng Zhang4, Zhiyao Liang5

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 385-398, 2020, DOI:10.32604/cmc.2020.06418

    Abstract In today’s datacenter network, the quantity growth and complexity increment of traffic is unprecedented, which brings not only the booming of network development, but also the problem of network performance degradation, such as more chance of network congestion and serious load imbalance. Due to the dynamically changing traffic patterns, the state-of the-art approaches that do this all require forklift changes to data center networking gear. The root of problem is lack of distinct strategies for elephant and mice flows. Under this condition, it is essential to enforce accurate elephant flow detection and come up with a novel load balancing solution… More >

  • Open Access


    Optimization Design of RC Ribbed Floor System Using Eagle Strategy with Particle Swarm Optimization

    Jiejiang Zhu1, *, Bolun Zhou1

    CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 365-383, 2020, DOI:10.32604/cmc.2020.06655

    Abstract The eagle strategy algorithm is combined with particle swarm optimization in this paper. The new algorithm, denoted as the ES-PSO, is implemented by interfacing Etabs structural analysis codes. ES-PSO is used to optimize the RC ribbed floor system, including floor and underground garage roof. By considering the effects of reinforcement, the principle of virtual work is applied to calculate the deflections of components. Construction cost is taken as the objective function and the constraint conditions are required to satisfy. Accordingly, the optimal layout, the optimal sections of the beams and slabs and the corresponding reinforcements are obtained for different column… More >

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