Zheng-qi Liu^∗, Ying Liu^∗,†, Tian-tian Liu^∗, Qing-shan Yang^‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 129-149, 2014, DOI:10.3970/mcb.2014.011.129

Abstract In this paper, the hemodynamic characteristics of blood flow and stress distribution in a layered and stenotic aorta are investigated. By introducing symmetrical and unsymmetrical stenosis, the influence of stenosis morphology and stenotic ratio on the coupled dynamic responses of aorta is clarified. In the analysis, the in-vivo pulsatile waveforms and fully fluid–structure interaction (FSI) between the layered elastic aorta and the blood are considered. The results show that the fluid domain is abnormal in the stenotic aorta, and the whirlpool forms at the obstructed and downstream unobstructed regions. The maximum wall shear stresses appear… More >

Chetan D. Kuthe^∗, R.V. Uddanwadiker^†, Alankar Ramteke^‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 113-128, 2014, DOI:10.3970/mcb.2014.011.113

Abstract Biomechanical researches are essential to develop new techniques to improve the clinical relevance. Skeletal muscle generates the force which results in the motion of human body, so it is essential to study the mechanical and structural properties of skeletal muscle. Many researchers have carried out mechanical study of skeletal muscle with in-vivo testing. This work aims to examine anisotropic mechanical behavior of skeletal muscle with in vitro test (tensile test). It is important to understand the mechanical and structural behavior of skeletal muscle when it is subjected to external loading; the research aims to determine… More >

Umadevi. B, Dinesh P.A., Indira R., Vinay. C.V

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 101-111, 2014, DOI:10.3970/mcb.2014.011.101

Abstract The mass transfer in an eccentric annular region through diffusion by taking blood as a Newtonian fluid with the investigation of oxygen transfer and drug transport to the tissue cells in an eccentric catheterized artery is studied. The region bounded by eccentric circles in x-y plane is mapped conformally to concentric circles in \(\xi -\eta\) plane using a conformal mapping \(z = \lambda /1 - \zeta\). The resulting governing equations are analytically solved by using transformation for the concentration. Numerical computations are carried out to understand the simultaneous~effects of absorption parameter and eccentricity on the More >

L. L. Xiao^∗, S. Chen^∗,†, C. S. Lin^∗, Y. Liu^‡

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 67-85, 2014, DOI:10.3970/mcb.2014.011.067

Abstract The motion and deformation of a single red blood cell flowing through a microvessel stenosis was investigated employing dissipative particle dynamics (DPD) method. The numerical model considers plasma, cytoplasm, the RBC membrane and the microvessel walls, in which a three dimensional coarse-grained spring network model of RBC’s membrane was used to simulate the deformation of the RBC. The suspending plasma was modelled as an incompressible Newtonian fluid and the vessel walls were regarded as rigid body. The body force exerted on the free DPD particles was used to drive the flow. A modified bounce-back boundary… More >

Hassan P. Modarres^∗, Mohammad R. K. Mofrad^†

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 39-65, 2014, DOI:10.3970/mcb.2014.011.039

Abstract Focal adhesions are the immediate sites of the cell’s adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light More >

Norizadeh Abbariki Tannaz^*,†, Shokrgozar Mohammad Ali^†,‡, Haghighipour Nooshin^*,§, Aghdami Nasser^¶, Mahdian Rezak^II, Amanzadeh Amir^*, Jazayeri Maryam^*,†

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 19-37, 2014, DOI:10.3970/mcb.2014.011.019

Abstract Background: Environmental factors affect stem cell differentiation. In addition to chemical factors, mechanical signals have been suggested to enhance myogenic differentiation of stem cells. Therefore, this study was undertaken to illustrate and compare the effect of chemical and mechanical stimuli on Myogenin (MyoG) and Myosin heavy chani 2 (Myh2) expression of mouse bone marrowderived mesenchymal stem cells (BMSCs) and embryonic stem cells (ESCs). Methods: After isolation and expansion of BMSCs and generation of embryoid bodies and spontaneous differentiation of ESCs, cells were examined in 4 groups: (1) control group: untreated cells; (2) chemical group: cells… More >

JA. Herzog^∗, TR. Leonard^†, A. Jinha^†, W. Herzog^†,‡

Molecular & Cellular Biomechanics, Vol.11, No.1, pp. 1-17, 2014, DOI:10.3970/mcb.2014.011.001

Abstract Titin is the third most abundant protein in sarcomeres and fulfills a number of mechanical and signaling functions. Specifically, titin is responsible for most of the passive forces in sarcomeres and the passive visco-elastic behaviour of myofibrils and muscles. It has been suggested, based on mechanical testing of isolated titin molecules, that titin is an essentially elastic spring if Ig domain un/refolding is prevented either by working at short titin lengths, prior to any unfolding of Ig domains, or at long sarcomere (and titin) lengths when Ig domain un/refolding is effectively prevented. However, these properties… More >

Rui Fan¹, Dalin Tang^2,3, Jing Yao⁴, Chun Yang⁵, Di Xu⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.6, pp. 491-508, 2014, DOI:10.3970/cmes.2014.099.491

Abstract Identifying ventricle material properties and its infarct area after heart attack noninvasively is of great important in clinical applications. An echo-based computational modeling approach was proposed to investigate left ventricle (LV) mechanical properties and stress conditions using patient-specific data. Echo data was acquired from one healthy volunteer (male, age: 58) and a male patient (age: 60) who had an acute inferior myocardial infarction one week before echo image acquisition. Standard echocardiograms were obtained using an ultrasound machine (E9, GE Mechanical Systems, Milwaukee, Wisconsin) with a 3V probe and data were segmented for model construction. Finite… More >

H. Y. Fang^1,2,3, J. Liu⁴, F. M. Wang^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.6, pp. 473-490, 2014, DOI:10.32604/cmes.2014.099.473

Abstract Construction of electromagnetic wave propagation model in layered pavement structure is a key step in back analysis of ground penetrating radar (GPR) echo signal. The precise integration method (PIM) is a highly accurate, efficient, and unconditionally stable algorithm for solving 1-order ordinary differential equations. It is quite suitable for dealing with problems of wave propagation in layered media. In this paper, forward simulation of GPR electromagnetic wave propagating in homogeneous layered pavement structure is developed by employing PIM. To verify the performance of the proposed algorithm, simulated GPR signal is compared with the measured one. More >

Emrah Yilmaz¹, Hikmet Koyunbakan²

CMES-Computer Modeling in Engineering & Sciences, Vol.99, No.6, pp. 463-471, 2014, DOI:10.3970/cmes.2014.099.463

Abstract In this study, Ambarzumyan’s theorem for quadratic Sturm-Liouville problem is extended to second order differential systems of dimension d ≥ 2. It is shown that if the spectrum is the same as the spectrum belonging to the zero potential, then the matrix valued functions both P(x) and Q(x) are zero by imposing a condition on P(x). In scaler case, this problem was solved in [Koyunbakan, Lesnic and Panakhov (2013)]. More >