Laurence H. Klotz

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 21-24, 2005

Abstract Background: Many newly diagnosed patients with prostate cancer have "good risk" disease. The challenge is to identify the minority of these patients with aggressive disease and offer them curative treatment, while sparing the remainder the morbidity of unnecessary treatment.
Purpose: To examine the results of active surveillance with selective delayed intervention in good risk prostate cancer patients.
Materials and methods: This was a prospective phase II study of active surveillance of 299 patients. Eighty percent (239 patients) met the criteria for good risk disease: PSA < 10 ng/mL, Gleason ≤ 6, T ≤ 2a. Twenty percent of patients,… More >

Th. H. Van der Kwast, R. Postma, R. F. Hoedemaeker, G. J. L. H. van Leenders, F. H. Schröder

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 16-20, 2005

Abstract Introduction: Prostate-specific antigen (PSA) testing of asymptomatic men may lead to the detection of "minimal" prostate cancers that are less likely to be associated with morbidity or mortality.
Objective: To examine the significance of various diagnostic outcomes from needle biopsies of the prostate in an asymptomatic population of men.
Methods: Prostatic needle biopsy findings were matched with those from radical prostatectomy specimens using data from the Rotterdam section of the European Randomized study of Screening for Prostate Cancer (ERSPC). Men, aged between 55 and 75 years, with elevated PSA levels underwent lateralized sextant needle biopsies. In corresponding radical… More >

Fred Saad¹, Paul Perrotte¹, François Bénard¹, Michael McCormack¹, Pierre I. Karakiewicz^1,2

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 9-15, 2005

Abstract With current treatments, men usually survive many years after being diagnosed with prostate cancer. However, the systemic effects of prostate cancer and therapies such as androgen deprivation therapy (ADT) can undermine skeletal integrity, resulting in skeletal complications that may erode quality of life (QOL). Prostate cancer patients are at risk for fractures from cancer treatment-induced bone loss. In addition, they are also at risk for pathologic fractures, severe bone pain, and other sequelae from bone metastases, which almost invariably occur during the progression of prostate cancer. This review investigates the incidence and pathophysiology of bone More >

Pierre I. Karakiewicz, Paul Perrotte, Mike McCormack, François Peloquin, Jean-Paul Perreault, Philippe Arjane, Hughes Widmer, Fred Saad

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 5-8, 2005

Abstract Introduction: Prostate biopsy strategies have greatly evolved over the past 2 decades.
Methods: We performed a literature review which addressed the initial and repeat biopsy schemes, pathologic risk factors for a positive repeat biopsy, and the ideal timing as well as the number of repeat biopsy sessions.
Results: Extended biopsy schemes (11-13 cores) should be used at initial and repeat biopsy. In the era of extended biopsy schemes, high-grade prostatic intraepithelial neoplasia no longer represents an independent predictor of prostate cancer on repeat biopsy. Conversely, the risk is appreciably increased with atypical small acinar proliferation, and its presence More >

Neil Fleshner, Rami Al Azab

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 2-4, 2005

Abstract Introduction: If an agent can slow the growth of existing prostate cancer cells, it remains plausible that it may be effective as an adjunct to surgery, radiation or chemotherapy.
Discussion: Level-1 evidence will be needed in order to definitively prove the efficacy of agents as chemoprevention strategies for prostate cancer. Currently, only finasteride fulfills this criterion. Two major trials are underway that will assess the role of soy, vitamin E and selenium in prostate cancer prevention.
Conclusion: Tantalizing prospects for effective of prostate cancer exist. Fortunately, well-conducted randomized trials will allow us to answer many of these questions More >

Fred Saad, Neil Fleshner

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 1-1, 2005

Abstract This article has no abstract. More >

Laurence H. Klotz

Canadian Journal of Urology, Vol.12, No.4, pp. 2726-2726, 2005

Abstract This article has no abstract. More >

Kevin C. Zorn, Sebastien Daigle, Francois Belzile, Le Mai Tu

Canadian Journal of Urology, Vol.12, No.1, pp. 2560-2563, 2005

Abstract Introduction: Since its description by Ulmsten, the TVT procedure has been proven to be safe and well tolerated. Bleeding and hematoma formation, although rare, can occur. Both conservative and surgical managements of this complication have been described.
Materials: We report the first case in which a pelvic branch of the obturator artery was embolized using angiography.
Results: Our patient was spared surgical exploration and retained the TVT tape.
Conclusion: Angiography with vessel embolization, when available, should be considered in the treatment of TVT-procedure retropubic hemorrhages. More >

Mana Al-Assiri, Zorn Kevin, Saleh Binsaleh, Peter T. K. Chan

Canadian Journal of Urology, Vol.12, No.1, pp. 2557-2559, 2005

Abstract Testicular cancer, which generally presents as a scrotal mass of variable sizes, is amongst the most common malignancies in men in the 15- to 35- year age group. A high inguinal orchiectomy is the standard approach for removal of a scrotal mass suspicious of being malignant. A recent report described a combined use of an inguinal incision, for early clamping of the spermatic cord, and a scrotal incision for orchiectomy of a large size testicular seminoma.1 We hereby report a case of a large size testis cancer removed using a single oblique inguinoscrotal incision. This More >

Ben H. Chew¹, Bodo E. Knudsen¹, Madeleine Moussa², Stephen E. Pautler¹

Canadian Journal of Urology, Vol.12, No.1, pp. 2555-2556, 2005

Abstract There are less than 100 cases of retroperitoneal schwannoma reported in the world literature. These are differentiated from gastrointestinal schwannomas found in the gastrointestinal tract. A case of a rare retroperitoneal gastrointestinal schwannoma presenting as a perinephric tumor is described. Treatment of such masses is local excision and final diagnosis is from histopathology. More >