@Article{,
AUTHOR = {Christoph Gräni, Dominik C. Benz, Mathias Possner, Olivier F. Clerc, Fran Mikulicic, Jan Vontobel, Julia Stehli, Tobias A. Fuchs, Aju P. Pazhenkottil, Oliver Gaemperli, Philipp A. Kaufmann, Ronny R. Buechel},
TITLE = {Fused cardiac hybrid imaging with coronary computed tomography angiography and positron emission tomography in patients with complex coronary artery anomalies},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {12},
YEAR = {2017},
NUMBER = {1},
PAGES = {49--57},
URL = {http://www.techscience.com/schd/v12n1/38720},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> To provide data on the value of fused cardiac hybrid imaging with coronary computed
tomography angiography (CCTA) and positron emission tomography myocardial perfusion imaging
(PET-MPI) in patients with complex coronary artery anomalies (CCAA).<br/>
<b>Design/setting:</b> This is a retrospective, single-center study.<br/>
<b>Patients:</b> Seven consecutive patients with CCAA (mean 57 ± 7 y, 86% were male) who underwent
clinically indicated hybrid CCTA/PET-MPI between 2005 and 2015 in our clinic were included. The
findings from both modalities and fused cardiac hybrid imaging were evaluated in these patients.<br/>
<b>Results:</b> Out of the seven patients with CCAA, two patients had Bland–White–Garland anomaly,
two patients showed a coronary artery fistula, two patients showed a “single right,” and one
patient showed a “single left” coronary artery. Semiquantitative fused hybrid CCTA/PET-MPI
depicted inferolateral scar matching the territory of a nonanomalous vessel with significant concomitant coronary artery disease (CAD) in one patient only. In contrast, analysis of quantitative
myocardial blood flow (MBF) as assessed by fused hybrid CCTA/PET-MPI revealed abnormally
reduced flow capacities in the territories subtended by the anomalous vessels in 4 patients.<br/>
<b>Conclusions:</b> In this case series of middle-aged patients with CCAA, perfusion defects as assessed by
semiquantitative PET-MPI were rare and attributable to concomitant CAD rather than to the anomalous
vessel itself. By contrast, impaired MBF as assessed by quantitative hybrid CCTA/PET-MPI was revealed
in the majority of patients in the vessel territories subtended by the anomalous coronary artery itself.
Fused hybrid CCTA/PET-MPI incorporating information on morphology and on semiquantitative and
quantitative myocardial perfusions may provide added value for the management of patients with CCAA.},
DOI = {}
}