@Article{chd.12451,
AUTHOR = {M. Elisabeth Heal, Lanier B. Jackson, Andrew M. Atz, Ryan J. Butts},
TITLE = {Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {12},
YEAR = {2017},
NUMBER = {4},
PAGES = {399--402},
URL = {http://www.techscience.com/schd/v12n4/39167},
ISSN = {3071-1738},
ABSTRACT = {Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation.
Effects of persistent fenestration on CPET variables have not been clearly defined. Associations
between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored
in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration -4.9 ±
3.8 v. nonfenestration -3 ± 3.5; P < .001). Physiological dead space at peak exercise was higher in
fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P = .03). There was a weak association
between fenestration patency and maximal work and heart rate. Fenestration patency was also
weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration
on CPET measurements was minimal in this study, likely due to the cross-sectional design.},
DOI = {10.1111/chd.12451}
}