@Article{chd.12470,
AUTHOR = {Katie E. Cohen, Matthew W. Buelow, Jennifer Dixon, Ruta Brazauskas, Scott B. Cohen, Michael G. Earing, Salil Ginde},
TITLE = {Forced vital capacity predicts morbidity and mortality in adults with repaired tetralogy of Fallot},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {12},
YEAR = {2017},
NUMBER = {4},
PAGES = {435--440},
URL = {http://www.techscience.com/schd/v12n4/39177},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous
thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in
adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of
abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF
when analyzed with other traditional cardiac risk factors.<br/>
<b>Design:</b> Retrospective study of adults with repaired TOF, who underwent spirometry between
2000 and 2014. FVC < 60% of predicted was categorized as moderate-to-severely reduced lung
function. Primary outcome measure was the combined clinical endpoint of death, cardiac transplantation, or nonelective hospitalization for primary cardiac or respiratory indication.<br/>
<b>Results:</b> A total of 122 patients were included. Average age at spirometry testing was 31 ± 10.1
years. FVC was < 60% predicted in 23 (19%) patients. During a mean follow-up period of 3.97 ±
2.65 years, 23 (19%) patients reached the combined clinical outcome of nonelective hospitalization and/or death. FVC < 60% predicted was independently associated with the risk for the
combined clinical outcome (RR 6.68 (95% CI 2.49–17.94), P < .001).<br/>
<b>Conclusions:</b> Abnormal pulmonary function characterized by reduced FVC is common in adults
with repaired TOF. Patients with FVC < 60% predicted had a 6 times higher rate of hospitalization
and/or death compared to those with FVC ≥60%.},
DOI = {10.1111/chd.12470}
}