@Article{chd.12555,
AUTHOR = {Yumi Shiina, Tomoaki Murakami, Noriko Matsumoto, Daisuke Okamura, Yuta Takahashi, Yosuke Nishihata, Nobuyuki Komiyama, Koichiro Niwa},
TITLE = {Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {13},
YEAR = {2018},
NUMBER = {1},
PAGES = {79--84},
URL = {http://www.techscience.com/schd/v13n1/38950},
ISSN = {3071-1738},
ABSTRACT = {<b>Objectives:</b> To assess body composition and relationships among body composition, appetiterelated hormones, adipocytokines, and heart failure (HF) in adult patients with congenital heart disease (CHD).<br/>
<b>Patients:</b> This prospective study enrolled 46 consecutive adult patients with CHD and 12 agematched healthy controls. The patients and control subjects were divided into four groups: 13
patients with Fontan circulation (group A), 16 patients with cyanosis (group B), 17 patients who
previously underwent biventricular repair (group C), and 12 age-matched healthy controls.<br/>
<b>Design:</b> Body composition was measured using InBody730, and levels of appetite-related hormones (ghrelin and leptin) and adipocytokines (leptin, interleukin-6, and tumor necrosis factor-a)
were determined. Relationships of these measurements between severe HF, defined as New York
Heart Association functional class III–IV and/or recent repeated unscheduled hospitalizations due
to HF, were examined using univariate logistic analysis.<br/>
<b>Results:</b> Mean patient age was 32.1 ± 7.4 years. The skeletal muscle mass was significantly
decreased in groups A and B compared with that in controls. Interestingly, ghrelin levels in groups
A and B were also significantly lower than those in controls. Univariate logistic analysis revealed
that ghrelin level, percent body fat, and pulse oximetric oxygen saturation were significantly associated with severe HF.<br/>
<b>Conclusions:</b> Patients with Fontan circulation and those with cyanosis might be at a risk of sarcopenia. Despite the decreased skeletal muscle mass and increased body fat, ghrelin levels in these
patients were decreased. These changes might have a negative impact on HF in these patients.},
DOI = {10.1111/chd.12555}
}