@Article{chd.12602,
AUTHOR = {Natasha L. Lopez, Charitha Gowda, Carl H. Backes, Deipanjan Nandi, Holly Miller-Tate, Samantha Fichtner, Robin Allen, Jamie Stewart, Clifford L. Cua},
TITLE = {Differences in midterm outcomes in infants with hypoplastic left heart syndrome diagnosed with necrotizing enterocolitis: NPCQIC database analysis},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {13},
YEAR = {2018},
NUMBER = {4},
PAGES = {512--518},
URL = {http://www.techscience.com/schd/v13n4/39020},
ISSN = {3071-1738},
ABSTRACT = {<b>Introduction:</b> Neonates with hypoplastic left heart syndrome (HLHS) are at increased risk for
necrotizing enterocolitis (NEC). Initial hospital outcomes are well described, but minimal midterm
data exist. Goal of this study was to compare outcomes of HLHS infants with NEC (HLHS-NEC) to
HLHS without NEC (HLHS-nNEC) during the interstage period.<br/>
<b>Methods:</b> Data were reviewed from 55 centers using the NPC-QIC database. Case-control study
with one HLHS-NEC matched to HLHS-nNEC neonates in a 1:3 ratio based on institutional site,
type of surgical repair, and gestational age ±1 week was performed. Baseline demographics as well
as outcome data were recorded. The t tests or chi-square tests were performed as appropriate.<br/>
<b>Results:</b> There were 57 neonates in the HLHS-NEC (14 Norwood-BT, 37 Norwood-RVPA, and 6
hybrid) and 171 neonates in the HLHS-nNEC group. There were significant differences between
the HLHS-NEC versus HLHS-nNEC for presence of atrioventricular valve regurgitation (7% vs 2%),
use of extracorporeal membrane oxygenation (11% vs 2%), hospital stay (60.4 ± 30.0 vs 36.3 ±
33.6 days), Z-score weight at discharge (-2.1 vs -1.6), incidence of no oral intake (33% vs 14%),
and use of formula only nutrition at discharge (61% vs 29%), respectively. There were no significant differences between groups in readmission rates due to adverse gastrointestinal events, use
of gastrointestinal medications, interstage deaths, or Z-score weight at time of second surgery.
HLHS-NEC continued to be more likely to be entirely tube dependent for enteral intake at time
prior to the second procedure (39% vs 15%).<br/>
<b>Conclusions:</b> Despite similar baseline characteristics, HLHS-NEC infants had significant differences
in hospital course compared with HLHS-nNEC neonates. In addition, HLHS-NEC infants were less
likely to be fed orally during the entire interstage period. Future studies are needed minimize NEC
in this high risk population to possibly improve oral feeds.},
DOI = {10.1111/chd.12602}
}