@Article{chd.12616,
AUTHOR = {Timur Mese, Baris Guven, Murat Muhtar Yilmazer, Cem Karadeniz, Rahmi Ozdemir, Onder Doksoz},
TITLE = {Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {13},
YEAR = {2018},
NUMBER = {4},
PAGES = {506--511},
URL = {http://www.techscience.com/schd/v13n4/39031},
ISSN = {3071-1738},
ABSTRACT = {<b>Background:</b> Mean platelet volume (MPV), platecrit, and platelet distribution width (PDW) are
markers of platelet activation. Previous studies have found that platelet activation occurs in
patients with pulmonary arterial hypertension. Platelet indices including MPV, PDW, and platecrit
have not been studied in children with congenital heart disease associated pulmonary arterial
hypertension (APAH-CHD) who survived and those who died.<br/>
<b>Objective:</b> The objective of this study to investigate the value of platelet indices with clinical and
hemodynamic indicators predicting the disease severity and survival in children with APAH-CHD.<br/>
<b>Methods:</b> This was a nested case-control study. MPV, platecrit, and PDW levels measured in 37
patients with APAH-CHD and 43 healthy subjects at the beginning of the study. Right heart catheterization was performed in all 37 patients. Clinical and hemodynamic data were collected. All
patients were followed from the date of laboratory testing. The study was conducted between
March 2012–July 2015. The comparison of clinical, hemodynamic data and platelet indices were
made between patients with APAH-CHD who died than APAH-CHD patients who survived.<br/>
<b>Results:</b> Of 37 patients, after a mean follow-up duration of 67.90 ± 47.90 months, 11 patients
died. MPV (12.10 femoliter [fL; 8.20–12.50] vs 8.70 fL [6.40–9.70], P = .007), PDW (16.88 ±
1.09% vs 15.75 ± 1.58%, P = .04) and platecrit (0.28 ± 0.31 vs 0.22 ± 0.27, P = .01) were significantly higher in the patients with APAH-CHD who died than those who survived. Pearson’s
correlation analysis showed that MPV correlated with mean pulmonary artery pressure (r = 0.332,
P 5 .04) and correlated negatively with six-minute walking distance (r = -0.600. P = .00). PDW
and platecrit correlated positively with mean pulmonary artery pressure (r = 0.373, P = .02;
r = 0.389, P = .01, respectively).<br/>
<b>Conclusion:</b> Our results showed that MPV, platecrit and PDW were increased in children with
APAH-CHD. They might give clue about disease severity.},
DOI = {10.1111/chd.12616}
}