TY  - EJOU
AU  - Marino, Pablo 
AU  - Lopes, Gabriella de Oliveira 
AU  - Borges, Juliana Pereira 
AU  - Cola, Maria Carolina Terra 
AU  - Kopiler, Daniel Arkader 
AU  - Tibirica, Eduardo 

TI  - Evaluation of systemic microvascular reactivity in adults with congenital heart disease
T2  - Structural and Congenital Heart Disease

PY  - 2018
VL  - 13
IS  - 6
SN  - 3071-1738

AB  - <b>Objective:</b> Adults with congenital heart disease share some features with those with 
chronic heart failure. Although microvascular endothelial dysfunction has been de‐
scribed in chronic heart failure, evaluation of the microcirculation in adults with con‐
genital heart disease is lacking. The present study aimed to investigate systemic 
microvascular reactivity in adults with congenital heart disease.<br/>
<b>Interventions:</b> The patients initially underwent cardiopulmonary exercise testing. Then, 
the cutaneous microvascular reactivity was evaluated in these patients using a laser 
speckle contrast imaging system coupled with skin iontophoresis of endothelial‐de‐
pendent (acetylcholine) or ‐independent (sodium nitroprusside) vasodilators and pos‐
tocclusive reactive hyperemia (PORH) and compared with healthy controls matched 
for age and sex.<br/>
<b>Results:</b> Thirty‐one patients and 29 healthy controls were evaluated. The basal micro‐
vascular flow (P < .0001) and area under the curve in response to acetylcholine 
(P < .0001) were higher in the patients than in the healthy volunteers. The increase in 
cutaneous vascular conductance in response to sodium nitroprusside was reduced in 
the patients compared to the healthy volunteers (P = .0031). No difference in the micro‐
vascular response was observed during postocclusive reactive hyperemia. The basal 
microvascular flow of patients with peak oxygen consumption below 16.0 mL kg<sup>‐1</sup> min<sup>‐1</sup>
was superior to that of patients with values greater than 16.0 mL kg<sup>‐1</sup> min<sup>‐1</sup> (P = .0046).<br/>
<b>Conclusions:</b> Adults with congenital heart disease present a higher baseline cutaneous 
microvascular blood flow than healthy controls and do not present systemic microvas‐
cular endothelial dysfunction. Nevertheless, endothelium‐independent microvascular 
reactivity is blunted, suggesting an altered vascular smooth muscle response or vascu‐
lar structural alterations. Finally, patients with a lower functional capacity presented a 
greater microvascular basal blood flow than subjects with a higher functional capacity.
KW  - congenital
KW  -  endothelium
KW  -  heart defects
KW  -  laser speckle contrast imaging
KW  -  microcirculation
KW  -  microvascular reactivity

DO  - 10.1111/chd.12660