@Article{chd.12691,
AUTHOR = {Kent A. Willis, Mark F. Weems},
TITLE = {Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {1},
PAGES = {27--32},
URL = {http://www.techscience.com/schd/v14n1/38731},
ISSN = {3071-1738},
ABSTRACT = {Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been 
linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been 
proven, the link is greatest among infants born at lower gestational age who are 
treated with mechanical ventilation in the presence of a large ductal shunt. Despite 
strong association in epidemiological studies, treatment of a patent ductus arteriosus 
has not been shown to prevent BPD, and some therapies may increase the risk of 
BPD. We describe preclinical and clinical data demonstrating the association of a 
PDA with BPD, highlight the effects of surgical and pharmacological treatment, and 
explore the implications of recent clinical trials for the management of PDA in the 
premature newborn.},
DOI = {10.1111/chd.12691}
}