@Article{chd.12714,
AUTHOR = {Stacey L. Crockett, Courtney D. Berger, Elaine L. Shelton, Jeff Reese},
TITLE = {Molecular and mechanical factors contributing to ductus arteriosus patency and closure},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {1},
PAGES = {15--20},
URL = {http://www.techscience.com/schd/v14n1/38746},
ISSN = {3071-1738},
ABSTRACT = {Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmo‐
nary artery and aorta, is complex. Failure of this vessel to close after birth may result 
in a persistent left‐to‐right shunt through the patent ductus arteriosus, a condition 
associated with significant morbidities. Numerous factors contribute to the shift from 
fetal ductus patency to postnatal closure, requiring precise coordination of molecular 
cues with biomechanical forces and underlying genetic influences. Despite significant 
advances, questions remain regarding signaling dynamics and the natural time course 
of ductus closure, particularly in preterm neonates. This review highlights the contri‐
butions of early investigators and more recent clinician scientists to our understanding 
of the molecular and mechanical factors that mediate ductus patency and closure.},
DOI = {10.1111/chd.12714}
}