@Article{chd.12727,
AUTHOR = {Jennifer L. Shepherd, Shahab Noori},
TITLE = {What is a hemodynamically significant PDA in preterm infants?},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {1},
PAGES = {21--26},
URL = {http://www.techscience.com/schd/v14n1/38750},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> There is no consensus on the definition of a hemodynamically significant 
patent ductus arteriosus (hsPDA). In this review article, our objective is to discuss the 
main variables that one should consider when determining the hemodynamic signifi‐
cance of a PDA.<br/>
<b>Results:</b> We describe the various approaches that have been utilized over time to 
define an hsPDA and discuss the strengths and weaknesses of each echocardio‐
graphic index. Finally, we propose a comprehensive and individualized approach in 
determining the hemodynamic significance of the PDA.<br/>
<b>Conclusion:</b> There are several PDA‐related clinical, echocardiographic, and other ob‐
jective variables to take into consideration when defining an hsPDA. However, vul‐
nerability based on gestational or chronological age is an important contributor as 
well.},
DOI = {10.1111/chd.12727}
}