@Article{chd.12683,
AUTHOR = {Masaki Sato, Kei Inai, Mikiko Shimizu, Hisashi Sugiyama, Toshio Nakanishi},
TITLE = {Bioelectrical impedance analysis in the management of heart failure in adult patients with congenital heart disease},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {2},
PAGES = {167--175},
URL = {http://www.techscience.com/schd/v14n2/38753},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> The recognition of fluid retention is critical in treating heart failure (HF). 
Bioelectrical impedance analysis (BIA) is a well-known noninvasive method; however, 
data on its role in managing patients with congenital heart disease (CHD) are limited. 
Here, we aimed to clarify the correlation between BIA and HF severity as well as the 
prognostic value of BIA in adult patients with CHD.<br/>
<b>Design:</b> This prospective single-center study included 170 patients with CHD admitted 
between 2013 and 2015. We evaluated BIA parameters (intra- and extracellular water, 
protein, and mineral levels, edema index [EI, extracellular water-to-total body water 
ratio]), laboratory values, and HF-related admission prevalence.<br/>
<b>Results:</b> Patients with New York Heart Association (NYHA) functional classes III-IV 
had a higher EI than those with NYHA classes I-II (mean ± SD, 0.398 ± 0.011 vs
0.384 ± 0.017, P < .001). EI was significantly correlated with brain natriuretic peptide 
level (r = 0.51, P < .001). During the mean follow-up period of 7.1 months, KaplanMeier analysis showed that a discharge EI > 0.386, the median value in the present 
study, was significantly associated with a future increased risk of HF-related admission (HR = 4.15, 95% CI = 1.70-11.58, P < .001). A body weight reduction during hospitalization was also related to EI reduction.<br/>
<b>Conclusions:</b> EI determined using BIA could be a useful marker for HF severity that 
could predict future HF-related admissions in adult patients with CHD.},
DOI = {10.1111/chd.12683}
}