@Article{chd.12782,
AUTHOR = {Alexander C. Egbe, Sindhura Ananthaneni, Raja Jadav, Srikanth Kothapalli, Charanjit S. Rihal, Muhammad Masood, Mounika Angirekula, Maria Najam, Numra Bajwa, Karim Tarek, Jessey Matthew, Heidi M. Connolly},
TITLE = {Coronary artery disease in adults with tetralogy of Fallot},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {3},
PAGES = {491--497},
URL = {http://www.techscience.com/schd/v14n3/38800},
ISSN = {3071-1738},
ABSTRACT = {<b>Background:</b> There are limited data about outcomes of coronary artery disease
(CAD) in adults with repaired tetralogy of Fallot (TOF). The purpose of this study was
to describe the prevalence and treatment of CAD in adults with TOF, and the impact
of CAD on long‐term survival.<br/>
<b>Methods:</b> Retrospective review of MACHD database for adults with repaired TOF
who underwent aortic root/selective coronary angiogram, 1990‐2017. Patients were
categorized into three groups: (1) No CAD defined as normal coronary angiogram; (2)
Mild CAD defined as ≤50% stenosis in all vessels; and, (3) Significant CAD defined
as >50% stenosis in any vessel.<br/>
<b>Results:</b> We identified 105 (23%) of 465 TOF patients that had angiograms; mean
age 47 ± 12 years. The prevalence of mild CAD and significant CAD was 19% (20 pa‐
tients) and 15% (16 patients), respectively. Of these 16 patient with significant CAD,
9 (56%), 3 (19%), and 4 (24%) patients received guideline directed medical therapy,
percutaneous coronary intervention, and coronary artery bypass grafting, respec‐
tively. Significant CAD was an independent risk factor for mortality (HR: 2.03, 95% CI
1.64‐4.22, P = .022) after adjustment for differences in age, and prevalence of atrial
fibrillation and renal dysfunction.<br/>
<b>Conclusions:</b> Based on a review of a selected cohort of 105 TOF patients, the preva‐
lence of mild CAD and significant CAD was 19% and 15%, respectively. Significant
CAD was an independent risk factor for mortality. There is need for more research
to determine optimal noninvasive diagnostic strategies and optimal patient selections
and methods for revascularization.},
DOI = {10.1111/chd.12782}
}