@Article{chd.12763,
AUTHOR = {Rachel Wong, Mohammed Al‐Omary, David Baker, Neil Spratt, Andrew Boyle, Natasha Baker Cert, Peter Howe, Nicholas Collins},
TITLE = {Cognitive dysfunction is associated with abnormal responses in cerebral blood flow in patients with single ventricular physiology: Novel insights from transcranial Doppler ultrasound},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {4},
PAGES = {638--644},
URL = {http://www.techscience.com/schd/v14n4/39282},
ISSN = {3071-1738},
ABSTRACT = {<b>Objectives:</b> Improvements in the management of complex congenital heart disease, 
including those with single ventricle physiology, have resulted in increased survival. 
As this population ages, the recognition of cognitive impairment is increasingly im‐
portant. At present, little is known about the potential mechanisms of cognitive dys‐
function. In this cross‐sectional study, we aimed to characterize the nature of 
abnormalities in cerebral blood flow and the relationship to cognitive deficits in 
adults with single ventricular physiology.<br/>
<b>Patients:</b> Ten adults with single ventricular physiology (age 18‐40 years) and 12 age‐ 
and gender‐matched controls underwent transcranial Doppler ultrasound and ac‐
companying cognitive assessment.<br/>
<b>Outcome Measures:</b> Patients underwent neuropsychological testing that assessed 
differing cognitive domains, with subjective cognitive decline determined from a 24‐
question survey. Transcranial Doppler ultrasound was used to assess baseline cere‐
bral blood flow as well as change in cerebral blood flow velocities from baseline and 
during cognitive testing. Age, ethnicity, individual, and parental education levels were 
considered in the multivariate analyses.<br/>
<b>Results:</b> On assessment of cognitive function, the patient group performed more 
poorly across each of the measured domains. The control group had a significantly 
greater increase in cerebral blood flow in response to cognitive stimuli compared to 
the patient cohort; these differences in response to cognitive stimuli were seen to a 
similar extent across each of the measured cognitive domains.<br/>
<b>Conclusion:</b> Adults with Fontan physiology are underperforming in assessments of 
executive function with associated abnormalities in cerebral perfusion potentially 
contributing to cognitive deficits.},
DOI = {10.1111/chd.12763}
}