@Article{chd.12768,
AUTHOR = {Alexander C. Egbe, William R. Miranda, Patricia A. Pellikka, Sorin V. Pislaru, Barry A. Borlaug, Srikanth Kothapalli, Sindhura Ananthaneni, Harigopal Sandhyavenu, Maria Najam, Mohamed Farouk Abdelsamid, Heidi M. Connolly},
TITLE = {Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {4},
PAGES = {657--664},
URL = {http://www.techscience.com/schd/v14n4/39287},
ISSN = {3071-1738},
ABSTRACT = {<b>Background:</b> We hypothesized that echocardiographic indices of right ventricular to
pulmonary artery (RV‐PA) coupling were comparable to cardiac magnetic resonance
imaging (CMRI)‐derived RV volumetric indices in predicting disease severity in
chronic pulmonary regurgitation (PR).<br/>
<b>Methods:</b> Patients with ≥ moderate PR (2003‐2015) with and without prior CMRI
scans were enrolled into the study cohort and validation cohort, respectively.
Endpoint was to determine the association between noninvasive RV‐PA coupling in‐
dices (tricuspid annular plane systolic excursion/right ventricular systolic pressure
[TAPSE/RVSP] and fractional area change [FAC]/RVSP ratio) and markers of disease
severity, and compared this association to that of CMRI‐derived RV volumetric indi‐
ces and markers of disease severity (peak oxygen consumption [VO2], NT‐proBNP
and atrial and/or ventricular arrhythmias).<br/>
<b>Results:</b> Of the 256 patients in the study cohort (age 33 ± 6 years), 187 (73%) had
tetralogy of Fallot (TOF) while 69 (27%) had valvular pulmonic stenosis (VPS). TAPSE/
RVSP (r = 0.73, P < .001) and FAC/RVSP (r = 0.78, P < .001) correlated with peak VO2. 
Among the CMRI‐derived RV volumetric indices analyzed, only right ventricular end‐
systolic volume index correlated with peak VO2 (r = −0.54, P < .001) and NT‐proBNP
(r = 0.51, P < .001). These RV‐PA coupling indices were tested in the validation cohort
of 218 patients (age 37 ± 9 years). Similar to the study cohort, TAPSE/RVSP (r = 0.59,
P < .001) and FAC/RVSP (r = 0.70, P < .001) correlated with peak VO2. TAPSE/RVSP
(but not FAC/RVSP) was also associated with arrhythmia occurrence in both the
study cohort and validation cohorts.<br/>
<b>Conclusion:</b> Noninvasive RV‐PA coupling may provide complementary prognostic
data in the management of chronic PR. Further studies are required to explore this
clinical tool.},
DOI = {10.1111/chd.12768}
}