@Article{chd.12783,
AUTHOR = {Alexander C. Egbe, Sorin V. Pislaru, Srikanth Kothapalli, Raja Jadav, Muhammad Masood, Mounika Angirekula, Patricia A. Pellikka},
TITLE = {The role of echocardiography for quantitative assessment of right ventricular size and function in adults with repaired tetralogy of Fallot},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {5},
PAGES = {700--705},
URL = {http://www.techscience.com/schd/v14n5/38841},
ISSN = {3071-1738},
ABSTRACT = {<b>Background:</b> Quantitative assessment of right ventricular (RV) systolic function by 
echocardiography is challenging in patients with congenital heart disease because of 
the complex geometry of the RV and the iatrogenic structural abnormalities resulting 
from prior cardiac surgeries. The purpose of this study was to determine the correla‐
tion between echocardiographic indices of RV systolic function and cardiac magnetic 
resonance imaging (CMRI) derived RV ejection fraction (RVEF) in adults with repaired 
tetralogy of Fallot (TOF).<br/>
<b>Methods:</b> Quantitative assessment of RV function was performed with RV tissue 
Doppler systolic velocity (RV s'), tricuspid annular plane systolic excursion (TAPSE), 
and fractional area change (FAC). These echocardiographic indices were compared to 
RVEF from CMRI performed on the same day as echocardiogram.<br/>
<b>Results:</b> Of 209 patients, the mean RV FAC was 39 ± 9%, TAPSE was 18 ± 4 mm, 
RV s' was 10 ± 2 cm/s, and RVEF was 40 ± 10%. There was a good correlation be‐
tween TAPSE and RVEF (r = 0.79, P < .001), good correlation between RV s' and RVEF 
(r = 0.71, P < .001), and modest correlation between FAC and RVEF (r = 0.66, P < .001). 
TAPSE < 17 mm effectively discriminated between patients with RV systolic dysfunc‐
tion defined as RVEF < 47% (sensitivity 81%, specificity 79%, area under the curve 
[AUC] 0.805). FAC < 40% was associated with RVEF < 47% (sensitivity 72%, specificity 
63%, AUC 0.719). RV s' < 11 cm was associated with RVEF < 47% (sensitivity 83%, 
specificity 68%, AUC 0.798).<br/>
<b>Conclusion:</b> Despite the structural and functional abnormalities of the RV in patients 
with repaired TOF, quantitative assessment of RV systolic function by echocardiog‐
raphy is feasible and had good correlation with CMRI‐derived RVEF.},
DOI = {10.1111/chd.12783}
}