@Article{chd.12822,
AUTHOR = {M. Louise Morrison, Brian Grant, Brian A. McCrossan, Andrew J. Sands, Colum G. Owens, Mark S. Spence, Frank A. Casey, Brian G. Craig, Christopher J. Lockhart},
TITLE = {32 year follow up of patients following atrial redirection surgery for transposition of the great arteries},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {5},
PAGES = {846--853},
URL = {http://www.techscience.com/schd/v14n5/38858},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> A significant body of patients who have undergone Mustard or Senning 
procedure require lifelong follow up. In this retrospective review, we examined the 
cohort of such patients currently attending our center.<br/>
<b>Design:</b> Patients who had undergone either Mustard or Senning procedure were 
identified. We retrospectively reviewed medical records, recorded demographic in‐
formation and data regarding the clinical state, NHYA class, cardiopulmonary exer‐
cise testing, NT‐proBNP measurement, and recent cardiac MRI findings.<br/>
<b>Results:</b> Forty‐six patients were identified, the mean age was 32.2 years (± 6.1 years), 
67.4% were male. Thirty‐two patients (69.6%) had undergone a Senning procedure. 
The median length of the follow‐up was 32 years. Thirty‐two patients (69.6%) were 
NHYA class 1. The mean VO<sub>2max</sub> achieved was 24.2 ± 5.8 mL/min/kg. The mean NT‐
proBNP was 266.4 pg/mL (± 259.9 pg/mL). The mean right ventricular end‐diastolic 
volume (RVEDV) was 212.4 mL ± 73.1 mL (indexed 114.2 mL/m<sup>2</sup> ± 34.4 mL/m<sup>2</sup>
). The 
mean right ventricular ejection fraction (RVEF) was 53.7% ± 7.9%. The mean left ven‐
tricular end‐diastolic volume (LVEDV) was 161.5 mL ± 73.7 mL (indexed 87.8 mL/
m<sup>2</sup> ± 41.1 mL/m<sup>2</sup>
). The mean left ventricular ejection fraction (LVEF) was 59.8% ± 
5.7%. There was a significant correlation between right ventricular (RV) size on MRI 
and NT‐proBNP level.<br/>
<b>Conclusions:</b> We present a relatively well cohort of patients with overall favorable 
long‐term outcome. The majority of patients are NHYA class 1 and the systemic right 
ventricular function appears to be well preserved as assessed by MRI. The exercise 
tolerance is reduced, with the majority of patients achieving around 60% of the esti‐
mated VO<sub>2max</sub>. Regular specialist follow‐up and assessment with advanced imaging at 
regular intervals remain important for this group.},
DOI = {10.1111/chd.12822}
}