@Article{chd.12852,
AUTHOR = {Natasa Karadzov Orlic, Amira Egic, Barbara Damnjanovic‐Pazin MD2 | Relja Lukic, Ivana Joksic, Zeljko Mikovic},
TITLE = {Screening performance of congenital heart defects in first trimester using simple cardiac scan, nuchal translucency, abnormal ductus venosus blood flow and tricuspid regurgitation},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {14},
YEAR = {2019},
NUMBER = {6},
PAGES = {1094--1101},
URL = {http://www.techscience.com/schd/v14n6/38920},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> The objective of this study was to analyze if the addition of simple 
cardiac scan in cases with increased nuchal translucency (NT) and/or abnormal ductus 
venosus (DV) blood flow, and/or tricuspid regurgitation (TCR) can improve detection 
of congenital heart defects (CHD) in chromosomally normal fetuses without non‐
cardiac defects at 11‐13 + 6 gestational weeks in a population of singleton pregnancies.<br/>
<b>Methods:</b> During the 10 years period, all singleton pregnancies at 11‐13 + 6 weeks 
were routinely scanned for NT, DV blood flow and TCR assessment and, if a sin‐
gle of these parameters was abnormal, simple cardiac scan with 2D gray scale and 
color and/or directional power Doppler in 4‐chamber (4‐CV) and 3 vessel and trachea 
views (3VTV) was performed.<br/>
<b>Results:</b> The sensitivity and specificity of NT ≥ 95th + DV R/A a‐wave + TCR in 
detecting CHD were 77% and 97%, respectively, and of simple cardiac scan, 67% 
and 98%, respectively. Area under the curve of receiver operating characteristic 
curve of NT ≥ 95th + DV R/A a‐wave + TCR was 0.838, and of NT ≥ 95th + DV R/A 
a‐wave + TCR + simple cardiac scan was 0.915.<br/>
<b>Conclusions:</b> In chromosomally normal fetuses without non‐cardiac anomalies, 
addition of simple cardiac scan to the combined first trimester screening parameters 
improves detection of major CHD during first trimester.},
DOI = {10.1111/chd.12852}
}