@Article{CHD.2020.011771,
AUTHOR = {Angeles Fuertes-Moure, Michael Meyer, Anna-Luisa Häcker, Barbara Reiner, Leon Brudy, Sonia Pértega-Diaz, Renate Oberhoffer, Peter Ewert, Jan Müller},
TITLE = {Longitudinal Health-Related Quality of Life Assessment in Children with Congenital Heart Disease},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {15},
YEAR = {2020},
NUMBER = {4},
PAGES = {217--227},
URL = {http://www.techscience.com/schd/v15n4/40124},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> Health-related quality of life (HRQoL) has become an
important outcome measure for patients with congenital heart disease (CHD).
The aim of this study was to evaluate the natural course of HRQoL from longitudinal assessment in children with CHD. <b>Patients and Methods:</b> From July
2014 to February 2020 this longitudinal study recruited 317 children with CHD
(113 girls, 35.6%) aged 6 to 18 years (11.6 ± 2.9 years). HRQoL was assessed
with the generic, self-reported and age-adapted KINDL<sup>®</sup> questionnaire. During
a mean follow-up period of 2.2 ± 1.3 years, 195 patients had one HRQoL reassessment, 70 two, 40 three and 12 patients four or more re-assessment, respective. <b>Results:</b> Overall HRQoL at baseline was 78.7 ± 9.3. During follow-up there
were no changes in HRQoL over time (0.03 [–0.01–0.07]; <i>p</i> = 0.195). In a linear
mixed model neither CHD severity, the diagnostic subgroup, age, BMI, surgical
history nor gender could be linked to a change in HRQoL during the follow-up
time. Only children with higher age baseline (–0.48 [–0.85––0.11]; <i>p</i> = 0.010)
had lower HRQoL. Same trend was seen for BMI (–0.19 [–0.41–0.03]; <i>p</i> =
0.099). <b>Conclusion:</b> Older children with CHD have significantly worse HRQoL,
but they evolve similarly to younger children over time. Since no demographic or
clinical variable could be linked to the course of HRQoL, it seems that individual
HRQoL courses are not predictable and routine HRQoL evaluations seem to be
necessary for acute decision making in clinical practice.},
DOI = {10.32604/CHD.2020.011771}
}