@Article{CHD.2021.015050,
AUTHOR = {Ruikun Zou, Yifei Wang, Chengcheng Pang, Yunxia Sun, Chen Chen, Jian Zhuang},
TITLE = {Screening Coarctation of Aorta with Clinical and Echocardiographic Profiles in Infants: A Pilot Study},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {16},
YEAR = {2021},
NUMBER = {2},
PAGES = {159--170},
URL = {http://www.techscience.com/schd/v16n2/41394},
ISSN = {3071-1738},
ABSTRACT = {<b>Aim:</b> To determine the profiles of clinical features including four-limb blood pressure (BP), saturations of peripheral oxygen (SpO<sub>2</sub>), and echocardiographic features in infants with coarctation of aorta (CoA) to facilitate congenital heart diseases screening. <b>Methods:</b> The charts of infants with CoA were retrospectively reviewed. All in-hospital infants suspected of congenital heart diseases by clinical teams were prospectively measured of four limbs BPs and SpO<sub>2</sub> in a regional cardiac transferring center during 2013 and 2019. Echocardiography as a gold standard test was followed within 2 days after suspicion. All infants were divided into non-significant CoA group or significant CoA group based on the difference of BPs between right arm and lower limbs. Predictors of non-significant CoA were determined with multivariable logistic regression. <b>Results:</b> One hundred thirty-three infants with CoA were identified. The BPs on upper limbs were higher than those on lower limbs (<i>P</i> = 0.001). No statistical difference in SpO<sub>2</sub> was found between four limbs. Fifty-three (39.8%) infants presented with significant CoA. Thirty-four infants presented with low SpO<sub>2</sub> and 26 of 34 presented with non-significant CoA. Small ascending aorta diameter [0.070 (95% CI: 0.005–0.136), <i>P</i> = 0.036] was an independent risk factors for non-significant CoA. Eighteen (13.5%) infants with CoA didn’t present with any of the BP difference, low SpO<sub>2</sub>, murmur, or weak femoral pulse. <b>Conclusion:</b> Less than half of the infants with CoA presented with a significant BP difference. Another one fifth presented with low SpO<sub>2</sub>. Small ascending aorta diameter was an independent factor for non-significant CoA.},
DOI = {10.32604/CHD.2021.015050}
}