TY  - EJOU
AU  - Taha, Fatma A. 
AU  - Amoudi, Osama 
AU  - Alnozha, Fareed 
AU  - Abuelatta, Reda 

TI  - Adults with Congenital Heart Disease during the COVID-19 Era: One-Year Tertiary Center Experience
T2  - Structural and Congenital Heart Disease

PY  - 2022
VL  - 17
IS  - 4
SN  - 3071-1738

AB  - <b>Background:</b> Adult patients with congenital heart disease (ACHD) might be at high risk of Coronavirus disease-
2019 (COVID-19). This study aimed to report on a one-year tertiary center experience regards COVID-19 infection in ACHD patients. Methods: This is a one-year (March-2020 to March-2021) tertiary-center retrospective
study that enrolled all ACHD patients; COVID-19 positive patients’ medical records, and management were
reported. <b>Results: </b>We recorded 542 patients, 205 (37.8%) COVID-19-positive, and 337 (62.2%) COVID-19-negative
patients. Palliated single ventricle and Eisenmenger syndrome patients were more vulnerable to COVID-19 infection
(<i>P</i> < 0.05*). Cardiovascular COVID-19 complications were arrhythmias in 47 (22.9%) patients, heart failure in
39 (19.0%) patients, cyanosis in 12 (5.9%) patients, stroke/TIA in 5 (2.4%) patients, hypertension and infective endocarditis in 2 (1.0%) patients for each, pulmonary hypertension and pulmonary embolism in 1 (0.5%) patient for
each. 11 (5.4%) patients were managed with home isolation, 147 (71.7%) patients required antibiotics,
32 (15.6%) patients required intensive care unit (ICU), 8 (3.9%) patients required inotropes, 7 (3.4%) patients
required mechanical ventilation, and 2 (1.0%) patients required extracorporeal membrane oxygenation (ECMO).
Thromboprophylaxis was given to all 46 (22.4%) hospitalized patients. American College of Cardiology/American
Heart Association classification revealed that complex lesions, and FC-C/D categories were more likely to develop
severe/critical symptoms, that required mechanical ventilation and ECMO (<i>P</i> < 0.05*). Mortality was reported in
3 (0.6%) patients with no difference between groups (<i>P</i> = 0.872). 193 (35.6%) patients were vaccinated. <b>Conclusions:</b>
COVID-19 infection in ACHD patients require individualized risk stratification and management. Eisenmenger
syndrome, single ventricle palliation, complex lesions, and FC-C/D patients were more vulnerable to severe/critical
symptoms that required ICU admission, mechanical ventilation, and ECMO. The vaccine was mostly tolerable.
KW  - Adult congenital heart disease; COVID-19 era; COVID-19 pandemic; COVID-19 positive congenital heart disease patients; COVID-19 infected adults with congenital heart disease

DO  - 10.32604/chd.2022.020174