TY  - EJOU
AU  - Li, Xingbang 
AU  - Zheng, Xuan 
AU  - Jin, Bowen 
AU  - Li, Yunyan 
AU  - Shao, Yongyu 
AU  - Deng, Xiaoxian 
AU  - Li, Dingyang 
AU  - Li, Shanshan 
AU  - Zhou, Hongmei 
AU  - Zhang, Jie 
AU  - Zhang, Xianya 
AU  - Shen, Qunshan 
AU  - Zhang, Gangcheng 

TI  - Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine: A Clinical Trial
T2  - Structural and Congenital Heart Disease

PY  - 2023
VL  - 18
IS  - 3
SN  - 3071-1738

AB  -  <b>Background:</b> Transcatheter closure of patent foramen ovale (PFO) has been widely accepted as a highly effective way to treat high-risk PFO-related diseases. However, traditional non-degradable occluders made of metal alloys will permanently exist in the body, resulting in thrombosis, valve damage, hemolysis, arrhythmia, or other complications. The biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co., Ltd., China can be fully absorbed and degrade into nontoxic ingredients, reducing postoperative complications. <b>Objectives:</b> To study the safety and efficacy of biodegradable PFO occluders in treating PFO. <b>Methods:</b> This single-center clinical trial collected 30 patients treated with a biodegradable PFO occluder. The follow-up period lasted 12 months to analyze the echocardiographic characteristics and headache relief through HIT-6 scores. <b>Results:</b> The immediate success rate was 100%, with no intraoperative severe occlusion-related complications. The contrast transcranial Doppler (cTCD) at 12 months showed that all patients’ right-to-left shunts (RLS) were grade I or 0 with no serious postoperative complications, indicating the overall success rate was 100%. The biodegradable PFO occluder mostly degraded six months after the occlusion. <b>Conclusion:</b> PFO closure with a Mallow biodegradable occluder is safe and effective and has no severe complications.
KW  - Patent foramen ovale; biodegradable occluder; transcatheter closure; migraine; complications

DO  - 10.32604/chd.2023.028979