TY  - EJOU
AU  - Siregar, Fajri Marindra 
AU  - Haryana, Sofia Mubarika 
AU  - Anggrahini, Dyah Wulan 
AU  - Dinarti, Lucia Kris 
AU  - Hartopo, Anggoro Budi 

TI  - The Potential of Circular RNAs as Biomarkers in Pulmonary Arterial Hypertension Related to Congenital Heart Disease
T2  - Structural and Congenital Heart Disease

PY  - 2024
VL  - 19
IS  - 4
SN  - 3071-1738

AB  - A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic biomarkers for PAH, discussed their biological functions, and addressed the challenges that need to be considered for their application in clinical settings.
KW  - Biomarker; circular RNA; congenital heart disease; pulmonary arterial hypertension

DO  - 10.32604/chd.2024.054742