@Article{schd.2026.082239,
AUTHOR = {Wenyi Luo, Li Yuan, Ruiling Feng, Kai Pu, Yali Huang, Mingxiong Li, Xiaomin Tang, Huimei Wang, Xuejing Wang, Wentin Zhang, Hong Zheng, Xiuhong Li, Dandong Luo, Shanshan Shi, Yaqin Shu, Xu Wang, Na Du, Yujie Shen, Yamin Song, Huihua Wang, Xia Xie, Qian Zhang, Qianqian Zhang, Yuanyuan Zhang, Yueyue Zhang, Xiaojie Hu, Zhimin Li, Xiaolan Pan, Youdong Pan, Wenyuan Shang, Hairui Sun, Beini Wang, Yanhua Wang, Yanyan Wang, Yongting Wang, Guihong Yang, Yan Zhou, Zhimin Yang, Xuanxuan Li, Huiwen Chen, Zhuoming Xu},
TITLE = {Chinese Expert Consensus on the Prevention and Management of Thrombosis Associated with Central Venous Catheters in Children with Congenital Heart Disease},
JOURNAL = {Structural and Congenital Heart Disease},
VOLUME = {21},
YEAR = {2026},
NUMBER = {2},
PAGES = {--},
URL = {http://www.techscience.com/schd/v21n2/67590},
ISSN = {3071-1738},
ABSTRACT = {<b>Objective:</b> To develop the Chinese expert consensus on the prevention and management of central venous catheter (CVC)-related thrombosis in children with congenital heart disease (CHD) (hereafter referred to as the Consensus), with the aim of standardizing and improving preventive and therapeutic strategies for CVC-related thrombosis in pediatric patients with CHD. <b>Methods:</b> The consensus was formulated in strict accordance with the principles of evidence-based medicine by a multidisciplinary panel of experts. Evidence was appraised and synthesized using the JBI Evidence Grading System. The initial draft was refined through two rounds of Delphi consultations involving 16 experts and one expert panel meeting with 15 participants. Statistical analyses demonstrated a high level of agreement among experts, leading to the establishment of a strong consensus. Subsequently, between September and November 2025, the document underwent further revision through an additional two rounds of Delphi surveys (n = 16) and one expert deliberation meeting (n = 15). Quantitative methods were employed to assess expert participation, authority, and the degree of consensus. <b>Results:</b> A two-round Delphi consultation was conducted with 16 experts per round, achieving a 100% effective response rate in both rounds. Fourteen experts provided constructive suggestions in the first round, and two in the second round. The expert authority coefficient (Cr) was 0.93 (familiarity coefficient 0.91, judgment basis coefficient 0.94). In the first round, item-level coefficients of variation (CVs) ranged from 0.05 to 0.21, and Kendall’s coefficient of concordance (W) was 0.158 (<i>χ</i><sup>2</sup> = 68.342, <i>p</i> &lt; 0.001). In the second round, CVs narrowed to 0–0.15 and Kendall’s W increased to 0.191 (<i>χ</i><sup>2</sup> = 72.565, <i>p</i> &lt; 0.001), indicating improved consensus. Subsequently, a panel review meeting with 15 experts (100% participation, Cr = 0.91) yielded CVs of 0–0.12 and Kendall’s W of 0.224 (<i>χ</i><sup>2</sup> = 59.118, <i>p</i> &lt; 0.001), demonstrating good consistency. Through this iterative process, the final consensus was established. <b>Conclusions:</b> The development of this consensus was methodologically rigorous, characterized by a highly representative expert panel and a strong level of agreement. It provides clinical nursing professionals with a structured and standardized framework for the prevention and management of CVC-related thrombosis in children with CHD. The consensus holds substantial clinical value in guiding standardized practice, reducing the incidence of thrombosis, and improving patient outcomes.},
DOI = {10.32604/schd.2026.082239}
}