Open Access

Take the Road Less Traveled: Pulmonary Artery Banding to Rescue the Children’s Failing Heart

Congenital Heart Disease, Vol.20, No.2, pp. 129-131, 2025, DOI:10.32604/chd.2025.064155 - 30 April 2025
Abstract This article has no abstract. More >

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ARTICLE

Hemodynamic Profile Based on Right Heart Catheterization in Adult Acyanotic Congenital Heart Disease with Pulmonary Hypertension

Congenital Heart Disease, Vol.20, No.2, pp. 133-141, 2025, DOI:10.32604/chd.2025.064164 - 30 April 2025
Abstract Background: Congenital heart disease (CHD) occurs in 9 out of 100 births and is the leading cause of birth defects, with acyanotic CHD being more common. The incidence of adult CHD is rising faster than pediatric CHD. Pulmonary hypertension is the most common complication in untreated CHD patients. Methods: This study is retrospective descriptive research based on medical record data and the results of right heart catheterization examinations in adult acyanotic CHD aged ≥18 years and free from other organ disorders. Results: A total of 103 patients met the inclusion criteria, the majority were young… More >

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REVIEW

Advances in Pediatric Heart Valve Replacement: A State-of-the-Art Review

Congenital Heart Disease, Vol.20, No.2, pp. 143-179, 2025, DOI:10.32604/chd.2025.064599 - 30 April 2025
Abstract Pediatric heart valve replacement (PHVR) remains a challenging procedure due to the unique anatomical and physiological characteristics of children, including growth and development, as well as the long-term need for durable valve function. This review provides an overview of both surgical and transcatheter options for aortic, mitral, pulmonary, and tricuspid valve replacements in pediatric patients, highlighting the indications, outcomes, and advancements in technology and technique. Surgical valve replacement traditionally involves the implantation of biological or mechanical prosthetic valves, with biological valves being preferred in children to reduce the need for lifelong anticoagulation therapy. However, the… More >

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103

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A Novel Transcatheter Suture Closure System for Patent Foramen Ovale: An Experimental Study in Swine

Congenital Heart Disease, Vol.20, No.2, pp. 181-193, 2025, DOI:10.32604/chd.2025.063297 - 30 April 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Objectives: This study aimed to evaluate the feasibility, safety, and efficacy of a novel transcatheter suture closure system (HaloStitch^®) for patent foramen ovale (PFO) closure in a swine model. Methods: Thirteen swine underwent experimental PFO model creation. All animals received implantation of the transcatheter suture closure system to evaluate procedural success. Comprehensive follow-up over six months included serial ultrasound imaging, histopathological analysis, and gross anatomical examination of cardiac specimens. Results: Successful HaloStitch^® device implantation was achieved in 11 of 13 swine. Gross anatomical examination confirmed secure positioning of all sutures in the atrial septum, with no redundancy or… More >

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LETTER

Percutaneous Transcatheter Closure of Congenital Atrial Septal Defect with Scoliosis under Transthoracic Echocardiography Guidance

Congenital Heart Disease, Vol.20, No.2, pp. 195-200, 2025, DOI:10.32604/chd.2025.063682 - 30 April 2025
（This article belongs to the Special Issue: Novel Methods and Techniques for the Management of Congenital Heart Disease)
Abstract Congenital atrial septal defect (ASD) with severe scoliosis is a rare compound malformation in children. Severe scoliosis should be corrected as soon as possible. The growth rod is suitable for patients with early scoliosis and obvious scoliosis under 10 years old. However, the fluoroscopic radiopaque of titanium alloy plate will inevitably partly make the operative field of interventional occlusion blind. We present a 7-year-old Chinese girl with ASD and scoliosis who underwent spinal correction with a dual-growth rod. In this case, we performed transcatheter closure of ASD solely under the guidance of transthoracic echocardiography. Transthoracic More >

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ARTICLE

Cardiothoracic Ratio for Assessment of Ventricular Volumes and Function in Patients with Repaired Tetralogy of Fallot

Congenital Heart Disease, Vol.20, No.2, pp. 201-211, 2025, DOI:10.32604/chd.2025.063217 - 30 April 2025
Abstract Background: The role of cardiothoracic ratio (CTR) from the chest radiograph for assessment of ventricular enlargement and function in repaired tetralogy of Fallot (TOF) is conflicting. This study aimed to determine the associations between CTR and cardiac magnetic resonance (CMR)-derived ventricular volumes and indices of ventricular function in adolescents and young adults with repaired TOF. Methods: The CTR and CMR findings, performed within 12 months of each other, were reviewed in 76 patients aged 22.1 ± 6.4 years. Associations between CTR and CMR parameters including right (RV) and left ventricular (LV) volumes and ejection fraction were… More >

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85

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Bioinformatics and In-Silico Findings Reveal Candidate Genes for Tetralogy of Fallot via Integrative Multi-Omics Data

Congenital Heart Disease, Vol.20, No.2, pp. 213-229, 2025, DOI:10.32604/chd.2025.064950 - 30 April 2025
Abstract Background: Tetralogy of Fallot (TOF), the predominant cyanotic congenital heart defect, arises from multifactorial gene-environment interactions disrupting cardiac developmental networks. This study investigated TOF-specific transcriptional alterations and identified high-confidence candidate genes. Methods: Based on GSE36761 transcriptome data, a weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network were conducted to identify TOF-related sub-network and Hub genes. The potential biological functions among these genes were revealed by enrichment analysis. Genetic, epigenetic and transcriptional alteration in the Hub genes were analyzed with leveraged public resources: a methylation dataset (GSE62629) and two single-cell datasets (EGAS00001003996 and GSE126128). Results:… More >

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ARTICLE

Predicting Factors of Physical Activity among Children with Congenital Heart Disease after Corrective Surgery

Congenital Heart Disease, Vol.20, No.2, pp. 231-244, 2025, DOI:10.32604/chd.2025.064662 - 30 April 2025
Abstract Objective: Many children with fully corrected congenital heart disease (CHD) avoid physical activity (PA). This descriptive study sought to determine child and parental factors that could predict PA levels in Thai children after corrective surgery. Methods: Ninety school-aged children with fully corrected CHD were recruited from a cardiology clinic at a university hospital in northern Thailand. Data collection involved five validated questionnaires: (1) the Modified Thai Adolescent’s Physical Activity Questionnaire, (2) the Child Health Status Questionnaire-Forms I and II, (3) the Parental Knowledge on School-aged Children’s Physical Activity Scale, (4) the Perceived Self-efficacy to Physical Activity… More >

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150

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REVIEW

Variants and Molecular Mechanism of NOTCH1 in Congenital Heart Disease

Congenital Heart Disease, Vol.20, No.2, pp. 245-263, 2025, DOI:10.32604/chd.2025.064366 - 30 April 2025
Abstract Congenital heart disease (CHD) is the most common birth defect, with 34% of cases attributed to genetic variants. NOTCH1, a multi-domain transmembrane protein, regulates heart development by controlling the differentiation and migration of myocardial mesoderm cells, and different variants are present in different types of CHD. In this review, we aim to provide a detailed description of NOTCH1 structural domains and their functions, highlighting NOTCH1 variants in CHD and the molecular mechanisms through which they contribute to CHD occurrence. NOTCH1 has two main domains, the NOTCH extracellular domain (NECD) and the NOTCH intracellular domain… More >

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ARTICLE

A Tense Race: Correlation of Liver Stiffness with Ultrasound Elastography and Hemodynamics in Fontan Patients

Congenital Heart Disease, Vol.20, No.2, pp. 265-272, 2025, DOI:10.32604/chd.2025.065661 - 30 April 2025
（This article belongs to the Special Issue: Novel Insights into Congenital Heart Disease: Pathophysiology, Biomarkers, and Future Directions)
Abstract Background: Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE. Methods: A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and… More >

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76

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ARTICLE

Quality of Life in Congenital Heart Disease Patients According to Their Anatomical and Physiological Classification

Congenital Heart Disease, Vol.18, No.2, pp. 197-206, 2023, DOI:10.32604/CHD.2021.013308
Abstract Background: Living well is as important as living longer. The objective of this study is to assess quality of life (QoL) in congenital heart disease (CHD) according to current AHA/ACC anatomical and physiological classifi- cation. Methods: Cross-sectional study examining the World Health Organization QoL Bref questionnaire (WHOQoL-Bref) in consecutive outpatient CHD patients from a single unit. Results: 191 CHD patients were studied. Median age was 28 ± 13 years and 59% were male. 44 (23%), 115 (60%) and 33 (17%) CHD patients showed mild, moderate and great anatomical defects respectively while 69 (36%) patients were in physiological… More >

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1653

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ARTICLE

Expert Consensus on Nutritional Support for Children with Congenital Heart Disease (2023 Edition)

Congenital Heart Disease, Vol.18, No.6, pp. 571-593, 2023, DOI:10.32604/chd.2024.048939
Abstract The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pediatric nutrition guidelines or consensus worldwide, the management of congenital heart disease, and the results of multi-center clinical nutrition research for congenital heart disease following the first Chinese consensus edition of 2016. The consensus was also shaped by the results of three discussion sessions and two questionnaires conducted by the 13-member collaboration group. This process was informed by both clinical guidelines and expert consensus. The quality of literature, both in English and Chinese, and the level of More >

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REVIEW

The Prevalence of Congenital Heart Disease among School-Age Children in China: A Meta-Analysis and Systematic Review

Congenital Heart Disease, Vol.18, No.2, pp. 127-150, 2023, DOI:10.32604/chd.2023.025616
Abstract Objectives: To estimate the prevalence of Congenital Heart Disease (CHD) in school-age children, to identify the extent to which altitude affects the prevalence of the disease, and to examine trends in prevalence over time in China. Methods: Seven databases were systematically searched and last retrieved on September 10, 2021 for all studies reporting the prevalence of CHD in children after 1970 in China, which were then divided into high and low altitude regions based on 2500 meters above sea level. The random-effected model was used to combine prevalence data and subgroups analysis. The baseline data of… More >

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ARTICLE

Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243
Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04),… More >

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595

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ARTICLE

Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451
Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first… More >

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ARTICLE

Single-Cell RNA Sequencing Reveals Potential for Endothelial-to-Mesenchymal Transition in Tetralogy of Fallot

Congenital Heart Disease, Vol.18, No.6, pp. 611-625, 2023, DOI:10.32604/chd.2023.047689
Abstract Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease. Endothelial-to-mesenchymal transition (EndoMT) is recognized as a physiological mechanism involved in embryonic heart development and endothelial formation. However, there is still a gap in the reports related to the mechanism of EndoMT development in TOF. Methods: First, transcriptomic data of single cell nuclei of TOF and Donor were obtained based on the Gene Expression Omnibus (GEO) database, and the data were normalized and clustered by dimensionality reduction using the Seurat package. Subsequently, differentially expressed genes (DEGs) between TOF and Donor were screened… More >

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1892

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635

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ARTICLE

Outcomes of Transcatheter Closure in Outlet-Type Ventricular Septal Defect after 1 Year

Congenital Heart Disease, Vol.18, No.2, pp. 169-181, 2023, DOI:10.32604/chd.2023.021238
Abstract Background: Ventricular septal defect (VSD) is the most common congenital heart disease. Transcatheter VSD closure is an effective treatment for patients with muscular and perimembranous VSD. However, there is a limit data for outlet VSD, especially impact to the aortic valve leaflet after transcatheter closure. This study aims to assess the outcomes of transcatheter closure of the outlet-type ventricular septal defect (OVSD) after 1 postoperative year. Methods: A retrospective study was performed including 50 patients who underwent transcatheter (n = 25) and surgical (n = 25) OVSD closure during the exact time frame at two medical centres. Results: The median age… More >

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ARTICLE

Early Cardiac Catheterizations within 30 Days Post Congenital Heart Surgery in Children

Congenital Heart Disease, Vol.18, No.1, pp. 79-95, 2023, DOI:10.32604/chd.2022.022401
Abstract Background: This study set out to assess the indications, feasibility, safety, and outcome of early cardiac catheterizations (CC) within 30 days after congenital heart surgery (CHS) in children. Methods and Results: This is a retrospective, single-center case review study of all CC within 30 days after CHS between 1/2010-12/2020. A total of 317 (138 diagnostic, 179 interventional) CC were performed in 245 patients at a median of 4 days (IQR 13) after CHS. The median age was 3 months (IQR 6), and body weight was 5 kg (IQR 4). A total of 194 (61.2%) CC were performed… More >

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ARTICLE

Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine: A Clinical Trial

Congenital Heart Disease, Vol.18, No.3, pp. 373-385, 2023, DOI:10.32604/chd.2023.028979
Abstract Background: Transcatheter closure of patent foramen ovale (PFO) has been widely accepted as a highly effective way to treat high-risk PFO-related diseases. However, traditional non-degradable occluders made of metal alloys will permanently exist in the body, resulting in thrombosis, valve damage, hemolysis, arrhythmia, or other complications. The biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co., Ltd., China can be fully absorbed and degrade into nontoxic ingredients, reducing postoperative complications. Objectives: To study the safety and efficacy of biodegradable PFO occluders in treating PFO. Methods: This single-center clinical trial collected 30 patients treated with a More >

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Ventricular Septal Crypts: Remnants of Spontaneous Interventricular Defect Closure?

Congenital Heart Disease, Vol.18, No.1, pp. 1-6, 2023, DOI:10.32604/chd.2023.025639
Abstract Background: Ventricular crypts are quite a common finding during cardiac imaging, but their etiology is unclear. A possible final result of a spontaneous ventricular septal defect closure has been supposed but never investigated in earlier studies. Method: From January 1997 to December 2020, all newborns diagnosed to have a ventricular septal defect were prospectively entered in our database and those with an isolated defect were included in the study. Ventricular septal defects were classified into four types: perimembranous, trabecular muscular, inlet and outlet. A long-term follow up was performed in order to visualize the possible residual… More >

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