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Regulatory, Therapeutic and Diagnostic Associations of miRNA in Emerging Diseases

Submission Deadline: 31 March 2021 (closed)

Guest Editors


Dr. Chiranjib Chakraborty, Adamas University, drchiranjib@yahoo.com


Professor Govindasamy Agoramoorthy, Tajen University, agoram@mail.nsysu.edu.tw

Summary

The discovery of the microRNAs (miRNAs) over two decades ago has led to the rapid evolution of scientific research focusing on this fascinating topic. Over 2,000 miRNAs have already been discovered so far in humans. They apparently regulate one third of the genes in the genome. The miRNAs have been implicated in numerous diseases affecting the humans. It has been reported that miRNAs regulate different diseases pathways through regulating various genes. It is also associated with the up and down regulation of different genes related to diverse diseases pathways. They play a distinct role to control the expression of different pathway proteins and thus they have a divergent regulatory role for emerging diseases.

 

In fact, the pathways of diseases can be regulated through the modulation of the different miRNA. On the other hand, several miRNAs have been modulated for therapeutic purposes we well. Some of the miRNA-based therapeutics is already undergoing preclinical and clinical trials. Similarly, they are being actively investigated as a potential clinical diagnostic. Circulating miRNAs can be used as a diseases marker for a range of diseases. Using miRNAs based biomarker, several next generation biomarkers can be developed and they could lead to rapid detection of different critical diseases. For all these intriguing reasons, we are organizing this special issue in BIOCELL to promote a series of high quality research papers emphasizing miRNAs functions, their associations and regulation mechanism to various diseases, next generation diagnostics and therapeutic potentials to deal the rapidly emerging human diseases in society. All the topics will be written by experts from these fields.

 

Potential topics to be covered in this special issue:

1. Regulatory Role of miRNAs in Heart Diseases

2. Regulatory Role of miRNAs in Brain Diseases

3. Regulatory Role of miRNAs in Bone Diseases

4. Regulatory Role of miRNAs in Liver Diseases

5. Regulatory Role of miRNAs in Different Types of Cancer

6. Different miRNA Based Therapeutics

7. Next Generation Diagnostics Development Using miRNA


Keywords

microRNA, Regulatory miRNA, Emerging Diseases, Therapeutics, Diagnostics

Published Papers


  • Open Access

    REVIEW

    MicroRNA regulation and host interaction in response to Aspergillus exposure

    MANSI SHRIVASTAVA, DIKSHA PANDEY, POONAM SHARMA, RAMBIR SINGH
    BIOCELL, Vol.46, No.2, pp. 339-356, 2022, DOI:10.32604/biocell.2022.016822
    (This article belongs to this Special Issue: Regulatory, Therapeutic and Diagnostic Associations of miRNA in Emerging Diseases)
    Abstract Aspergillus is a group of conidial fungi, isolated from soil and litter, cause serious diseases in humans and animals. This ubiquitous fungus is prevalent in the air and inhalation of fungal spores is common. Fungal diseases from Aspergillus became a major health problem and are difficult to manage because they tend to be chronic and invasive, hard to diagnose and difficult to exterminate with antifungal drugs. Although, immune responses play vital roles in monitoring the fate of fungal infections and regulation of the immune responses against fungal infections might be an effective approach for controlling and reducing the pathological damages.… More >

  • Open Access

    ARTICLE

    Propofol inhibits cells migration and invasion via HOTAIR/miR-93/HIF-1α-mediated lactate secretion in colon cancer

    RUONAN GU, WENJING GUO, WENYANG WANG, GUIHUAN LI, XIAOJU LAI, ZHIBIN HUANG, WANLU ZHAO, ZHICONG WU, HUA CHEN, WENYANG LUO, FANGYIN ZENG, FAN DENG
    BIOCELL, Vol.45, No.6, pp. 1585-1599, 2021, DOI:10.32604/biocell.2021.017016
    (This article belongs to this Special Issue: Regulatory, Therapeutic and Diagnostic Associations of miRNA in Emerging Diseases)
    Abstract Propofol, a common intravenous anesthetic used in clinical, has been shown to regulate cells proliferation, inflammation, angiogenesis and metastasis as well as exerting anti-cancer effect in several different types of cancer. However, the functions and mechanisms of propofol in lactate secretion and invasion of cancer cells remain unknown. The primary aim of this study was to investigate the role of propofol in cells migration and invasion of colon cancer (CRC). Scratches assay, Transwell assay were used to detect colon cells migration and invasion. Real-time Quantitative Polymerase Chain Reaction (RT-qPCR), Western blotting were utilized to detect the expression of related molecules.… More >

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