Heavy metals like cadmium, lead, and mercury in soil threaten crop growth and food safety. This review explores how modern technologies—genomics, transcriptomics,...
The image illustrates an intelligent driver monitoring framework for enhancing transportation safety. The system analyzes visual cues from the driver using deep...
Within a neuronal nucleus, contrasting DNA states symbolize the dual role of double-strand breaks in the brain. Transient, regulated breaks support activity-dependent...
Tech Science Press (TSP) is pleased to announce that five of its journals have been included in China’s 2025 list of the world’s leading science and technology journals. The five TSP journals...
The Canadian Journal of Urology (CJU) officially became a DOAJ (Directory of Open Access Journals)-indexed journal on 03 September 2026, marking another important milestone in the journal’s...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Quantum computational fluid dynamics (QCFD) is an active but still immature research area, and quantum lattice Boltzmann methods (QLBM) provide a natural...
The fusion of GNNs and SSMs is creating a new era in the realm of dynamical learning with structures. Graph-Mamba is one of the most promising works in...
Autonomous navigation poses a key challenge in Artificial Intelligence (AI), necessitating agents to plan and execute actions in complex, partially visible...
Large Language Models (LLMs) have rapidly evolved into general-purpose systems with broad applicability across information access, reasoning, decision...
Lattice-based post-quantum cryptographic standards such as Module-Lattice Key Encapsulation Mechanism (ML-KEM) and Module-Lattice-Based Digital Signature...
Increasing digitalization exposes critical infrastructure to sophisticated cyber threats, requiring new approaches to improving security and resilience....
Semiconductors represent the most complex production activities and stand at the forefront of smart manufacturing. In particular, the yield of advanced...
The design of steel and alloy materials is of critical importance across a wide range of industrial applications; however, effective intelligent agent-based...
Large Vision-Language Models (LVLMs) have achieved strong performance in multimodal perception, understanding, and generation, but their ability to perform...
The development of accurate digital twin models of the human cornea is a key factor for planning and monitoring eye treatments and clinical supervision....
Due to the complex and dynamic nature of multi-phase interfaces, accurately capturing interface evolution remains one of the key challenges in multi-phase...
Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1...
Non-coding RNAs (ncRNAs) and cholesterol metabolism have independently been recognized as critical regulators of cancer progression. NcRNAs modulate various...
Despite the advancements achieved in chemotherapy, cancer continues to remain a formidable and lethal global threat, ranking as the second leading cause...
Connected automated driving increasingly relies on cooperative perception from onboard sensors, roadside units (RSUs), smart traffic lights, and vehicle-to-everything...
The unique topological properties of the electronic band structures in topological materials have increasingly attracted attention in both fundamental...
The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...
The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...
Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...
Welcome to the Special Issue on "Modeling and Applications of Bubbles and Droplets in Engineering and Sciences". This fascinating field...
The tumor microenvironment (TME) plays a crucial role in cancer progression, metastasis, and resistance to therapy, prompting a shift in focus from targeting...
Tumor biomarkers have become an essential foundation for advancements in cancer diagnosis, prognosis, and targeted therapy. As oncology moves towards...
Artificial Intelligence of Things (AIoT) is considered a collaborative application of artificial intelligence (AI) and the Internet of Things (IoT). The...
Natural fibre-reinforced composites are increasingly being considered as sustainable alternatives to synthetic composites for lightweight automotive applications. The aim of this study was to evaluate the influence of flax fibre architecture and areal weight on the mechanical, morphological, and thermal performance of epoxy-based composites. Laminates were manufactured by vacuum bagging using twill 2/2 and biaxial flax fabrics with areal weights of 200, 250, 350, and 400 g/m2. Mechanical properties were assessed through tensile, flexural, and Charpy…
This study investigated the effect of bamboo fiber (BF) content on properties of polylactic acid (PLA) composites, using polypropylene (PP) as a control for comparative purposes. Initially, the BF was evaluated in four particle sizes (300, 200, 90, and 50 μm) through dynamic mechanical analysis to identify the most suitable particle size regarding viscoelastic behavior. The 50 μm fiber was selected based on a multi-criteria approach balancing interfacial restriction, structural stiffness, and microstructural homogeneity. Subsequently,…
The environmental burden of petroleum-based cushioning materials has driven the search for sustainable, bioderived alternatives. This study developed mycelium-based biofoams from locally available agro-industrial residues, rubberwood sawdust, and grass jelly pulp using Pleurotus ostreatus, Lentinus squarrosulus, and Ganoderma lucidum. The effects of nutritional supplementation, substrate morphology, and processing conditions on growth behavior and material performance were systematically investigated. Nutritional supplementation significantly enhanced fungal colonization, with bran increasing the growth rate of L. squarrosulus to 17.0 mm/day and promoting dense,…
A synergistic effect of adsorption and photocatalysis provides a key role ensuring high degradation efficiency. In this study, nanocellulose (nC) derived from oil palm empty fruit bunch (OPEFB) via delignification followed by acid hydrolysis was combined with CuO for methylene blue (MB) removal through a two-stage process: adsorption followed by photocatalysis. The nC content varied at 5%, 15%, and 25% by mass. Structural analyses revealed successful extraction of nC from OPEFB, with particle sizes of…
Paper ages naturally by heat, oxidation, and hydrolysis, which cause a progressive loss of mechanical strength. This study achieved a high yield of 93% amorphous SiO2 from rice husk waste through controlled calcination at 450°C (3 h) and 800°C (2 h), alkaline extraction with 2.5 N NaOH, acid precipitation with 1 N HCl and freeze-drying. The resulting nano-silica particles were incorporated into a 3% w/v hydroxyethyl cellulose (HEC) binder to prepare a 2% w/v impregnation solution,…
Kenaf fibre has attracted increasing attention as a sustainable reinforcement material for polymer composites, particularly for applications in marine environments where lightweight structures, corrosion resistance, and environmental compatibility are essential. This review critically examines the current state of research on kenaf fibre–reinforced composites for marine applications, focusing on their mechanical performance, environmental durability, processing methods, and sustainability potential. Existing studies consistently indicate that kenaf fibres offer favourable strength-to-weight ratios, low density, and renewable characteristics, making…
Background: Volatile anesthetics such as sevoflurane are ubiquitous in perioperative care, yet their unintended consequences on pulmonary microvascular integrity and the upstream intracellular signaling pathways remain incompletely defined. This study elucidates the precise transcriptional mechanisms linking sevoflurane exposure to pulmonary endothelial hyperpermeability. Methods: Transendothelial electrical resistance (TEER) and macromolecular permeability were dynamically quantified in human pulmonary microvascular endothelial cell (HPMEC) monolayers following sevoflurane exposure. Global transcriptomic profiling (RNA-seq) was employed to identify core regulatory nodes, which…
Oxidative stress results from an imbalance between reactive oxygen species (ROS) production and antioxidant defense mechanisms and contributes to cellular damage and the pathogenesis of various diseases. This review summarizes recent advances in the molecular and biochemical mechanisms associated with oxidative stress in ocular diseases, including dry eye disease, diabetic retinopathy, age-related macular degeneration (AMD), glaucoma, and cataract. A literature search was conducted using PubMed and Google Scholar databases to identify relevant studies published up
Background: Macrophage-derived eicosanoids are involved in airway inflammation associated with asthma, but the mechanisms regulating their production remain incompletely understood. The study aimed to evaluate the effects of isorhynchophylline (IRN) on eicosanoid production and inflammatory activation in LPS/IFN-γ-stimulated THP-1-derived macrophages and to further investigate whether these effects are mediated through the miR-200a/FOXC1/NF-κB axis. Methods: THP-1 cells were differentiated into M0 (PMA) and polarized into M1 (LPS+IFN-γ) phenotypes. IRN (5–20 μM) was applied. Eicosanoids (PGE2, LTB4) were measured…
Neutrophil extracellular traps (NETs) are increasingly recognized as significant contributors to neurovascular damage following ischemic brain injuries. This review examines how NETs link intravascular thrombosis to downstream neuroinflammation via a pathway-centric framework. We synthesize recent preclinical and clinical evidence showing that NET-derived histones, extracellular DNA, and granular enzymes activate convergent inflammatory pathways, including the high mobility group box 1–Toll-like receptor 4 axis, nuclear factor kappa B, Janus kinase 2/signal transducer and transcription activator 3, NOD-like
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy often diagnosed at advanced stages and associated with poor prognosis. This review aims to summarize the role of Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling in OSCC progression, with particular emphasis on its involvement in the regulation of autophagy, apoptosis, and oxidative stress. KRAS contributes to tumor progression despite the low frequency of activating mutations, primarily through increased KRAS expression associated with activation of downstream
Objective: Periodontal diseases can cause pro-inflammatory cytokine overproduction, particularly tumor necrosis factor-alpha (TNF-α), and this inflammatory microenvironment is a critical driver of oral cancer progression. MicroRNA-146a-5p is a key regulator of inflammation, linked to both periodontal disease and carcinogenesis. The objective of this study was to illustrate the regulatory function of miR-146a-5p in gingival squamous cell carcinoma OECM-1 cells under conditions that mimic those of periodontal disease. Methods: OECM-1 cells were stimulated with 25 ng/mL TNF-α…
Objectives: Middle ear cholesteatoma (MEC) is a destructive and locally invasive disease that leads to erosion of bone structure and serious complications. This study aimed to investigate the role of GDF11 in promoting the differentiation of macrophages into osteoclasts in vitro and elucidate the bone erosion mechanism in MEC. Methods: The MEC dataset GSE116142 was subjected to bioinformatics analysis. The Growth Differentiation Factor 11 (GDF11) and Transforming Growth Factor Beta Receptor 1 (TGFBR1) expression levels in MEC…
Metabolically–dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and is increasingly recognized as a systemic disorder at the intersection of metabolic dysregulation, inflammation, and carcinogenesis. Progression from simple steatosis to metabolic dysfunction–associated steatohepatitis (MASH), fibrosis, and hepatocellular carcinoma (HCC) reflects the interplay between metabolic overload, oxidative stress, immune activation, and gut microbiota dysbiosis. In this review, we propose the Redox–Microbiota–Inflammatory Axis as an integrative framework linking metabolic stress to fibrogenesis
Objectives: Tumor-associated macrophages (TAMs) within the hypoxic tumor microenvironment critically drive colorectal cancer (CRC) progression, yet their specific regulatory mechanisms on endoplasmic reticulum (ER) homeostasis via microRNAs remain understood. This study aims to assess the impact of hypoxia-induced TAMs on CRC cells through the microRNA-320 (miR-320)/SRY-box transcription factor 4 (SOX4) axis, focusing on ER homeostasis and malignant behaviors. Methods: Human CRC cell lines HCT116 and SW480 were co-cultured with hypoxia-induced macrophages. Cells were treated with miR-320…
Telomere homeostasis is intrinsically integrated into the cellular metabolic network through a complex mito-nuclear communication system. Telomeric chromatin acts as a sensitive sensor of mitochondrial flux, where the stability of telomeres depends on mitochondrial-derived metabolites essential for epigenetic remodeling. Three primary axes govern this control: (1) Acetyl-CoA-mediated histone acetylation necessary for human Telomerase Reverse Transcriptase (hTERT) expression; (2) the competitive balance between α-ketoglutarate/succinate, modulating Jumonji-C (JmjC)-demethylases and Ten-eleven translocation (TET) enzymes; (3) the mitochondrial NAD+/NADH ratio,…
Guest Editors: Van-Tu Nguyen; Ould el Moctar; Anh Dinh Le; Hemant J. Sagar Deadline: 30 September 2027
Guest Editors: Jin-Gyun Kim; Hee-Sun Choi; Seongji Han Deadline: 30 September 2027
Guest Editors: Hung-Yu Lin; Hsing-Ju Wu Deadline: 31 May 2027
Guest Editors: Carlos Vargas-Salgado; Dácil Diaz-Bello Deadline: 30 April 2027
Guest Editors: Leonardo Di G. Sigalotti; Carlos A. Vargas; Carlos E. Alvarado-Rodríguez Deadline: 30 April 2027
Guest Editors: Sabrina Tosi; Annabelle Lewis Deadline: 30 April 2027
Guest Editors: Wenlong Sun; Mengyao Li Deadline: 31 March 2027
Guest Editors: Wenbing Zhao; Pan Wang Deadline: 31 March 2027
Guest Editors: Wenfeng Zheng; Choon Kit Chan; Kyungtae Kang; Chao Liu Deadline: 31 March 2027
Guest Editors: Joanna Zawitkowska; Małgorzata Mitura-Lesiuk; Maciej Dubaj Deadline: 28 February 2027
Guest Editors: Wenfeng Zheng; Lirong Yin; Shan Liu Deadline: 15 February 2027
Guest Editors: Wei-Chiang Hong; Yi Liang; Ming-Wei Li; Zhong-Yi Yang Deadline: 15 February 2027
Guest Editors: Jungpil Shin; Yong Seok Hwang Deadline: 31 January 2027
Guest Editors: Denise Mafra; Jessyca Sousa de Brito Deadline: 31 January 2027
Guest Editors: Qi Chen; Yunhui Tang Deadline: 31 December 2026
Guest Editors: Hung-Yu Lin Deadline: 31 December 2026






