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Oncology Research
REVIEW

Understanding the Tumor Microenvironmental Mechanisms Driving Immunotherapy Resistance in Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality...

Oncology Research
REVIEW

Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications

Malignant melanoma (MM) is a highly aggressive skin cancer known for its rapid progression, potential for metastasis, and resistance to treatment. Despite...

Oncology Research
REVIEW

Ferroptosis as a Translational Axis in Small Cell Lung Cancer: A Systematic Review of Redox Pathways and Precision Oncology Prospects

Background: An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC)....

Oncology Research
REVIEW

Novel Immunotherapeutic Approaches for Patients with Head and Neck Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often...

Oncology Research
ARTICLE

Serum Biomarkers in Bladder Cancer: NMR Metabolomics for Identification and Monitoring during Platinum-Based Therapy

Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics...

Computers, Materials & Continua
REVIEW

A Survey on Multimodal Emotion Recognition: Methods, Datasets, and Future Directions

Multimodal emotion recognition has emerged as a key research area for enabling human-centered artificial intelligence, supported by the rapid progress...

Computers, Materials & Continua
ARTICLE

Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation

In materials science and engineering design, high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical...

Computers, Materials & Continua
ARTICLE

A Materials Discovery Method Considering the Trade-Off Phenomenon in Machine Learning Prediction Capabilities between Interpolation and Extrapolation: Case Study on Multi-Objective Mg-Zn-Al Alloy Design

The exploration of high-performance materials presents a fundamental challenge in materials science, particularly in predicting properties for materials...

Computers, Materials & Continua
ARTICLE

LEAF: A Lightweight Edge Agent Framework with Expert SLMs for the Industrial Internet of Things

Deploying Large Language Model (LLM)-based agents in the Industrial Internet of Things (IIoT) presents significant challenges, including high latency...

Fluid Dynamics & Materials Processing
ARTICLE

Numerical Assessment of Novel Windbreak Designs for Flow Control and Heat Transfer Enhancement in Natural Draft Dry Cooling Towers

This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing...

Fluid Dynamics & Materials Processing
REVIEW

Fluid Flow in Fractured Rocks: From Multiphysics Paradigms to AI-Driven Predictive Modeling

Fluid flow through fractured rock masses is a key process controlling the safety and performance of deep geoengineering systems, shaped by the complex...

Fluid Dynamics & Materials Processing
REVIEW

An Overview of Drag Reduction Methods in Road Cars

Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag, with the awareness that this may succeed in effectively...

Frontiers in Heat and Mass Transfer
ARTICLE

Experimental Study on Heat Transfer Characteristics of New Jacketed Cold Storage Condenser

In response to the actual demands of the energy storage type organic Rankine power generation cycle, this study proposes a new type of jacketed shell...

Frontiers in Heat and Mass Transfer
REVIEW

Enhancing Heat Exchanger Performance through Passive Techniques: A Comprehensive Review

Heat exchangers play a crucial role in thermal energy systems, with their performance directly impacting efficiency, cost, and environmental impact. A...

Canadian Journal of Urology
REVIEW

Association between periodontal disease and prostatic disease: a systematic review and meta-analysis of observational studies

Objective: Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic...

Energy Engineering
REVIEW

The Hydrogen Paradigm and Global Hydrogen Transition—Environmental Challenges and Strategic Steps towards a Sustainable Energy System

Discussions about the future of energy sources and environmental sustainability are becoming critical on a global scale. The energy sector plays a central...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges

This special issue, “Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges,” showcases the transformative power of...

Revue Internationale de Géomatique
Special Issue

Advancements in Geospatial Methods and Technologies for Sustainable Built Environment and Engineering

This theme captures the essence of advanced technologies (AI, machine learning, big data), modern applications (climate change, smart cities, health research),...

Oncology Research
Special Issue

Transcriptome Analysis in Tumor Microenvironment and Tumor Heterogeneity

The tumor microenvironment encompasses not only the tumor cells themselves, but also the surrounding fibroblasts, immunological and inflammatory cells,...

Oncology Research
REVIEW

Understanding the Tumor Microenvironmental Mechanisms Driving Immunotherapy Resistance in Colorectal Cancer Liver Metastases

Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality...

Oncology Research
REVIEW

Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications

Malignant melanoma (MM) is a highly aggressive skin cancer known for its rapid progression, potential for metastasis, and resistance to treatment. Despite...

Oncology Research
REVIEW

Ferroptosis as a Translational Axis in Small Cell Lung Cancer: A Systematic Review of Redox Pathways and Precision Oncology Prospects

Background: An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC)....

Oncology Research
REVIEW

Novel Immunotherapeutic Approaches for Patients with Head and Neck Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer and typically involves the head and neck. Systemic therapy is often...

Oncology Research
ARTICLE

Serum Biomarkers in Bladder Cancer: NMR Metabolomics for Identification and Monitoring during Platinum-Based Therapy

Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics...

Computers, Materials & Continua
REVIEW

A Survey on Multimodal Emotion Recognition: Methods, Datasets, and Future Directions

Multimodal emotion recognition has emerged as a key research area for enabling human-centered artificial intelligence, supported by the rapid progress...

Computers, Materials & Continua
ARTICLE

Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation

In materials science and engineering design, high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical...

Computers, Materials & Continua
ARTICLE

A Materials Discovery Method Considering the Trade-Off Phenomenon in Machine Learning Prediction Capabilities between Interpolation and Extrapolation: Case Study on Multi-Objective Mg-Zn-Al Alloy Design

The exploration of high-performance materials presents a fundamental challenge in materials science, particularly in predicting properties for materials...

Computers, Materials & Continua
ARTICLE

LEAF: A Lightweight Edge Agent Framework with Expert SLMs for the Industrial Internet of Things

Deploying Large Language Model (LLM)-based agents in the Industrial Internet of Things (IIoT) presents significant challenges, including high latency...

Fluid Dynamics & Materials Processing
ARTICLE

Numerical Assessment of Novel Windbreak Designs for Flow Control and Heat Transfer Enhancement in Natural Draft Dry Cooling Towers

This study aims to mitigate crosswind-induced performance degradation in Natural Draft Dry Cooling Towers used in power plants by developing and assessing...

Fluid Dynamics & Materials Processing
REVIEW

Fluid Flow in Fractured Rocks: From Multiphysics Paradigms to AI-Driven Predictive Modeling

Fluid flow through fractured rock masses is a key process controlling the safety and performance of deep geoengineering systems, shaped by the complex...

Fluid Dynamics & Materials Processing
REVIEW

An Overview of Drag Reduction Methods in Road Cars

Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag, with the awareness that this may succeed in effectively...

Frontiers in Heat and Mass Transfer
ARTICLE

Experimental Study on Heat Transfer Characteristics of New Jacketed Cold Storage Condenser

In response to the actual demands of the energy storage type organic Rankine power generation cycle, this study proposes a new type of jacketed shell...

Frontiers in Heat and Mass Transfer
REVIEW

Enhancing Heat Exchanger Performance through Passive Techniques: A Comprehensive Review

Heat exchangers play a crucial role in thermal energy systems, with their performance directly impacting efficiency, cost, and environmental impact. A...

Canadian Journal of Urology
REVIEW

Association between periodontal disease and prostatic disease: a systematic review and meta-analysis of observational studies

Objective: Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic...

Energy Engineering
REVIEW

The Hydrogen Paradigm and Global Hydrogen Transition—Environmental Challenges and Strategic Steps towards a Sustainable Energy System

Discussions about the future of energy sources and environmental sustainability are becoming critical on a global scale. The energy sector plays a central...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges

This special issue, “Applied Artificial Intelligence: Advanced Solutions for Engineering Real-World Challenges,” showcases the transformative power of...

Revue Internationale de Géomatique
Special Issue

Advancements in Geospatial Methods and Technologies for Sustainable Built Environment and Engineering

This theme captures the essence of advanced technologies (AI, machine learning, big data), modern applications (climate change, smart cities, health research),...

Oncology Research
Special Issue

Transcriptome Analysis in Tumor Microenvironment and Tumor Heterogeneity

The tumor microenvironment encompasses not only the tumor cells themselves, but also the surrounding fibroblasts, immunological and inflammatory cells,...

Mitigating Fragmentation Attacks in DNP3-Based Microgrids through Permissioned Blockchain Validation

The Distributed Network Protocol 3 (DNP3) is widely deployed in SCADA-based microgrids; however, it was not originally designed to meet the cybersecurity requirements of modern decentralized energy infrastructures. Although DNP3 Secure Authentication (DNP3-SA) introduces HMAC-based session-level protection, it does not ensure fragment-level integrity, leaving the protocol vulnerable to fragmentation disruption, replay attacks, and sequence manipulation. Such vulnerabilities can cause desynchronization between master and outstation devices, compromising the operational reliability of distributed energy resources. This paper…

Journal on Artificial Intelligence
Article

Comparative Performance Analysis of Machine Learning Algorithms for Early Detection of Heart Disease

Cardiovascular diseases remain one of the leading causes of mortality worldwide, making early and reliable diagnosis a critical challenge for modern healthcare systems. In this study, a systematic comparative performance analysis of widely used machine learning algorithms is conducted for the early detection of heart disease using tabular clinical data. Rather than proposing a novel model architecture, the primary objective is to provide a fair, reproducible, and clinically meaningful evaluation of commonly adopted classifiers under…

Journal on Artificial Intelligence
Article

Artificially Intelligent Interviewer—A Multimodal Approach

This paper presents an innovative system designed to automate the analysis of candidate interviews by integrating multiple analytical techniques into a single multimodal framework. This system combines text sentiment analysis, audio sentiment analysis, keyword extraction, and Mel-Frequency Cepstral Coefficients (MFCC) feature extraction to evaluate candidate performance holistically. This system employs text sentiment analysis using VADER and transformer-based sentiment features (probability-based outputs), audio sentiment analysis with an SVM model trained on both IEMOCAP and MELD datasets,

European Cytokine Network
review

Re-evaluating cytokine storm syndromes: dysregulated host defense or contextual immune adaptation?

Cytokine storm syndromes have become a much-invoked concept to describe severe immunopathology in infectious, inflammatory, and iatrogenic diseases, but the concept is poorly defined and often mechanistically imprecise. High levels of systemic cytokines have often been viewed as indicators of immune dysfunction, and based on this notion, therapeutic interventions focused on general cytokine inhibition are proposed. Nevertheless, a growing number of clinical and experimental data dispute the notion that hypercytokinemia is necessarily pathological. The present…

European Cytokine Network
review

Propolis as a potential modulator of aryl hydrocarbon receptor signaling in inflammation

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that exhibits antagonistic pleiotropy, mediating both protective and detrimental cellular effects depending on the ligand and context. AhR can be activated by a variety of endogenous and exogenous stimuli, including environmental pollutants, UVB radiation, heme, arachidonic acid metabolites, gut microbiota–derived compounds, and xenobiotics. Upon activation, AhR translocates to the nucleus, where it dimerizes with the aryl hydrocarbon receptor nuclear translocator (ARNT) and binds to xenobiotic…

European Cytokine Network
article

Co-expression of CCR7 and H3K9me3 identifies aggressive B-cell lymphoma with bone marrow infiltration and poor prognosis

Objectives: B-cell lymphoma exhibits significant clinical heterogeneity, necessitating improved biomarkers for risk stratification. C-C chemokine receptor 7 (CCR7) and trimethylation of histone H3 lysine 9 (H3K9me3) are implicated in cellular senescence and tumor invasion. While the clinical significance of their co-expression in lymphomagenesis remains unclear. This study aims to define the expression profiles of CCR7 and H3K9me3 in B-cell lymphoma, explore their correlation with aggressive clinical indicators, and evaluate their combined prognostic value. Methods: The…