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Computer Modeling in Engineering & Sciences
ARTICLE

DA-T3D: Distribution-Aware Cross-Modal Distillation Framework for Temporal 3D Object Detection

Knowledge distillation bridges the performance gap between camera-based and LiDAR-based 3D detectors by leveraging the precise geometric information from...

Computer Modeling in Engineering & Sciences
REVIEW

A Review of Genetic Algorithms: Principles, Procedures, and Applications in Optimization

This paper provides a thorough examination of Genetic Algorithms (GAs), a category of evolutionary computation methods derived from the concepts of natural...

Computer Modeling in Engineering & Sciences
REVIEW

A Review on Emerging Unified Information–Physics Frameworks for Structural Design: Toward Topology Optimization Informatics

Topology optimization (TO) has become a core computational paradigm for structural design by defining optimality through physics-based objectives and...

Energy Engineering
ARTICLE

Data-Driven and Physics-Informed Surrogate Modeling for Heat Conduction in the Pressurizer Wall of Pressurized Water Reactors under Severe Accident Scenarios

Real-time prediction of temperature distribution in the pressurizer walls of Pressurized Water Reactors (PWRs) during severe accidents, such as Station...

Energy Engineering
ARTICLE

Hydraulic Fracture Conductivity Loss Mechanisms for Unconsolidated Sands Considering Fine Migrations and Proppant Embedments

To investigate the mechanism governing the continuous decline in fracture conductivity of unconsolidated sandstone reservoirs post-hydraulic fracturing,...

Energy Engineering
ARTICLE

Assessment of Carbon Reduction Potential Driven by High Energy Consumption Enterprises’ Electricity Usage Behavior

Addressing global climate challenges necessitates urgent low carbon transitions in high energy consuming enterprises (HECEs). This study proposes a comprehensive...

Oncology Research
REVIEW

The Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer

The advent of immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 has transformed the therapeutic landscape of advanced non-small cell...

Oncology Research
REVIEW

AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance

The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research,...

Oncology Research
REVIEW

Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a hematopoietic malignancy originating from hematopoietic stem cells. It is characterized by the Philadelphia chromosome,...

Oncology Research
REVIEW

Current Advances in Preclinical Patient-Derived Cultivation Models for Individualized Drug Response Prediction in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cancer-related cause of death worldwide and is forecasted to become the second...

Computers, Materials & Continua
REVIEW

Multiscale Numerical Simulation of Dynamic Damage and Fracture in Metallic Materials: A Review

This paper provides a comprehensive review of recent advances in multi-scale modeling for simulating dynamic damage and fracture in metallic materials,...

Computers, Materials & Continua
REVIEW

Task Offloading and Edge Computing in IoT—Gaps, Challenges and Future Directions

This review examines current approaches to real-time decision-making and task optimization in Internet of Things systems through the application of machine...

Computers, Materials & Continua
REVIEW

3D Single Object Tracking in Point Clouds: A Review

3D single object tracking (SOT) based on point clouds is a fundamental task for environmental perception in autonomous driving and dynamic scene understanding...

Computers, Materials & Continua
REVIEW

Applications of Machine Learning in Polymer Materials: Property Prediction, Material Design, and Systematic Processes

This paper reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine...

Computers, Materials & Continua
ARTICLE

Machine Learning-Enhanced Multiscale Computational Framework for Optimizing Thermoelectric Performance in Nanostructured Materials

The direct conversion of solid-state heat to electricity using thermoelectric materials has attracted attention; however, their effective application...

Computers, Materials & Continua
ARTICLE

Robust Facial Landmark Detection via Transformer-Conv Attention

In facial landmark detection, shape deviations induced by large poses and exaggerated expressions often prevent existing algorithms from simultaneously...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Next-Generation Intelligent Networks and Systems: Advances in IoT, Edge Computing, and Secure Cyber-Physical Applications

The rapid evolution of next-generation intelligent networks and cyber-physical systems has transformed industries by enabling seamless connectivity, real-time...

Computer Modeling in Engineering & Sciences
ARTICLE

DA-T3D: Distribution-Aware Cross-Modal Distillation Framework for Temporal 3D Object Detection

Knowledge distillation bridges the performance gap between camera-based and LiDAR-based 3D detectors by leveraging the precise geometric information from...

Computer Modeling in Engineering & Sciences
REVIEW

A Review of Genetic Algorithms: Principles, Procedures, and Applications in Optimization

This paper provides a thorough examination of Genetic Algorithms (GAs), a category of evolutionary computation methods derived from the concepts of natural...

Computer Modeling in Engineering & Sciences
REVIEW

A Review on Emerging Unified Information–Physics Frameworks for Structural Design: Toward Topology Optimization Informatics

Topology optimization (TO) has become a core computational paradigm for structural design by defining optimality through physics-based objectives and...

Energy Engineering
ARTICLE

Data-Driven and Physics-Informed Surrogate Modeling for Heat Conduction in the Pressurizer Wall of Pressurized Water Reactors under Severe Accident Scenarios

Real-time prediction of temperature distribution in the pressurizer walls of Pressurized Water Reactors (PWRs) during severe accidents, such as Station...

Energy Engineering
ARTICLE

Hydraulic Fracture Conductivity Loss Mechanisms for Unconsolidated Sands Considering Fine Migrations and Proppant Embedments

To investigate the mechanism governing the continuous decline in fracture conductivity of unconsolidated sandstone reservoirs post-hydraulic fracturing,...

Energy Engineering
ARTICLE

Assessment of Carbon Reduction Potential Driven by High Energy Consumption Enterprises’ Electricity Usage Behavior

Addressing global climate challenges necessitates urgent low carbon transitions in high energy consuming enterprises (HECEs). This study proposes a comprehensive...

Oncology Research
REVIEW

The Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer

The advent of immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 has transformed the therapeutic landscape of advanced non-small cell...

Oncology Research
REVIEW

AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance

The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research,...

Oncology Research
REVIEW

Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a hematopoietic malignancy originating from hematopoietic stem cells. It is characterized by the Philadelphia chromosome,...

Oncology Research
REVIEW

Current Advances in Preclinical Patient-Derived Cultivation Models for Individualized Drug Response Prediction in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cancer-related cause of death worldwide and is forecasted to become the second...

Computers, Materials & Continua
REVIEW

Multiscale Numerical Simulation of Dynamic Damage and Fracture in Metallic Materials: A Review

This paper provides a comprehensive review of recent advances in multi-scale modeling for simulating dynamic damage and fracture in metallic materials,...

Computers, Materials & Continua
REVIEW

Task Offloading and Edge Computing in IoT—Gaps, Challenges and Future Directions

This review examines current approaches to real-time decision-making and task optimization in Internet of Things systems through the application of machine...

Computers, Materials & Continua
REVIEW

3D Single Object Tracking in Point Clouds: A Review

3D single object tracking (SOT) based on point clouds is a fundamental task for environmental perception in autonomous driving and dynamic scene understanding...

Computers, Materials & Continua
REVIEW

Applications of Machine Learning in Polymer Materials: Property Prediction, Material Design, and Systematic Processes

This paper reviews the research progress and application prospects of machine learning technologies in the field of polymer materials. Currently, machine...

Computers, Materials & Continua
ARTICLE

Machine Learning-Enhanced Multiscale Computational Framework for Optimizing Thermoelectric Performance in Nanostructured Materials

The direct conversion of solid-state heat to electricity using thermoelectric materials has attracted attention; however, their effective application...

Computers, Materials & Continua
ARTICLE

Robust Facial Landmark Detection via Transformer-Conv Attention

In facial landmark detection, shape deviations induced by large poses and exaggerated expressions often prevent existing algorithms from simultaneously...

Oncology Research
Special Issue

Advances in the Discovery and Development of Novel Anticancer Compounds

The rapid evolution of chemical biology, medicinal chemistry, and molecular pharmacology continues to drive the discovery of innovative anticancer compounds...

Oncology Research
Special Issue

Epigenetics and Epitranscriptomics in Cancer Biology and Therapy

Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and...

Energy Engineering
Special Issue

Model-based and Learning Methods for Optimization and Management of Energy Flows in Decentralized Smart Grids

The transition toward decentralized smart grids is reshaping the way energy is generated, exchanged, controlled, and consumed. The increasing penetration...

BIOCELL
Special Issue

Epigenetic and ncRNA Biomarkers in Cancer: Diagnostic and Prognostic Value

Cancer remains one of the leading causes of morbidity and mortality worldwide, and its onset and progression are closely linked to dysregulated epigenetic...

Journal of Polymer Materials
Special Issue

Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical Applications

We propose a special issue titled "Innovative Smart Polymeric Materials for Sustainable Energy Solutions: Bridging Advances in Energy and Biomedical...

Fluid Dynamics & Materials Processing
Special Issue

Fluid and Thermal Dynamics in the Development of Unconventional Resources III

Further advancements in the exploitation of unconventional resources, such as tight gas, shale gas, shale oil, coalbed methane, and natural gas hydrate,...

Computer Modeling in Engineering & Sciences
Special Issue

Machine Learning and Deep Learning-Based Pattern Recognition

In today’s digital era, patterns are omnipresent, shaping many aspects of our lives. These patterns can be physically observed or computationally identified...

Computer Modeling in Engineering & Sciences
Special Issue

Next-Generation Intelligent Networks and Systems: Advances in IoT, Edge Computing, and Secure Cyber-Physical Applications

The rapid evolution of next-generation intelligent networks and cyber-physical systems has transformed industries by enabling seamless connectivity, real-time...

Baclofen Inhibits Glioma Proliferation via the MEK/ERK/CREB Pathway

Objectives: Gamma-aminobutyric acid type B (GABAB) receptors are involved in tumor progression, and baclofen exerts broad-spectrum antitumor effects in various cancers. Nevertheless, its specific function and underlying molecular mechanisms in glioma are still largely unclear. This study aimed to evaluate the effects of baclofen on glioma cells and elucidate the associated signaling pathways. Methods: The antitumor effects of baclofen were evaluated in glioma cell lines, and its underlying molecular mechanisms were explored using transcriptome sequencing integrated…

Oncology Research
Article

Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study

Objectives: Germline variants in cancer predisposition genes have been increasingly recognized in pediatric cancers. However, their spectrum in East Asian children with central nervous system (CNS) tumors remains insufficiently defined. This study investigated the prevalence and clinical significance of pathogenic or likely pathogenic (P/LP) germline mutations in Korean children, adolescents, and young adults (AYAs) with CNS tumors. Methods: We performed targeted next-generation sequencing of 358 cancer-associated genes using peripheral blood DNA from 108 patients. Germline variants…

Oncology Research
Article

Circulating Tumor DNA and microRNA–Based Liquid Biopsy for Longitudinal Treatment Monitoring and Recurrence Prediction in Pediatric Sarcomas: A Prospective Cohort Study

Background: Pediatric sarcomas are aggressive malignancies characterized by marked biological heterogeneity and a high risk of relapse. Standard surveillance relies on imaging and invasive biopsies, which may fail to detect early molecular disease. Liquid biopsy using circulating tumor DNA (ctDNA) and microRNAs offers a minimally invasive strategy for longitudinal monitoring. This study aimed to evaluate dynamic changes in ctDNA and circulating microRNAs during treatment and examined their associations with treatment response, disease recurrence, and survival outcomes.…

Oncology Research
Article

Exosomes-Transferred lncRNA H19 Reverses Osimertinib Resistance by Upregulating PTEN via Sponging miR-148-3p in Non-Small Cell Lung Cancer

Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles of exosomal lncRNA H19 in modulating osimertinib resistance, focusing on the PI3K-PTEN-Akt signaling axis. Methods: Functional assays, including cell viability assay, colony formation, cell apoptosis and xenograft mouse, employed in evaluate the effects of exosomal…

Oncology Research
Article

UCK2 Drives Lung Adenocarcinoma Progression and Immune Dysregulation via the RHEB/mTOR Signaling Axis

Objectives: Uridine-cytidine kinase 2 (UCK2) plays a crucial role in the pyrimidine salvage pathway, but its function in lung adenocarcinoma (LUAD) is still largely unclear. The study aimed to investigate the expression, prognostic value, biological functions, and molecular mechanisms of UCK2 in LUAD. Methods: Bioinformatic analyses were performed using The Cancer Genome Atlas (TCGA), Gene Set Cancer Analysis (GSCA), Gene Expression Omnibus (GEO), and Genotype Tissue Expression (GTEx) datasets. In vitro assays evaluated the effect of UCK2…

Oncology Research
Review

After a Decade of Therapy Revolution in Cutaneous Melanoma—Perspectives on Emerging Treatment Strategies

Over the past decade, the therapeutic paradigm of cutaneous melanoma has been transformed strongly, driven by advances in immuno-oncology and precision medicine. Building on the success of immune checkpoint blockade and targeted therapy, new treatment strategies now aim to improve efficacy, overcome resistance, and prolong the durability of responses. Clinical trials on neoadjuvant therapy supporting its clinical use are presented. Furthermore, the latest progress in combinatorial immune checkpoint inhibition such as dual anti-LAG-3 or anti-TIGIT…

Oncology Research
Article

SFXN3 Serves as a Predictive Biomarker for Cisplatin Response and Survival in Head and Neck Squamous Cell Carcinoma

Objective: The systematic evaluation of expansive genomic databases facilitates the discovery of clinically vital biomarkers. While Sideroflexin 3 (SFXN3) consistently displays elevated expression in head and neck squamous cell carcinoma (HNSCC), its specific pathobiological functions and prognostic value remain insufficiently characterized. This study aims to delineate the clinical and functional significance of SFXN3 in HNSCC. Methods: We interrogated SFXN3 expression patterns, patient survival outcomes, and immune cell infiltration characteristics utilizing multiple independent repositories, including the cancer…

Oncology Research
Article

Identification of BRCA2 Likely Germline Pathogenic Variants in Patients with Multiple Primary Lung Adenocarcinomas

Objectives: Genetic risk models have substantially advanced our understanding of germline pathogenic variants (GPVs) in some malignancies, whereas their clinical significance in lung cancer remains unclear. The present study aimed to better understand potential contribution of GPVs to lung cancer etiology. Methods: A targeted sequencing panel of 143 cancer-related genes was applied to analyze 26 distinct lung adenocarcinoma (LUAD) tumors from 11 patients histopathologically diagnosed with multiple primary lung cancers (MPLC). Tumor classification was performed through…

Oncology Research
Article

Multifunctional Lipid Nanoparticles Remodeling Tumor Immune Microenvironment for Breast Cancer Chemo-Immunotherapy

Background: Breast cancer treatment is often hampered by the immunosuppressive tumor microenvironment (TME). To improve therapeutic efficacy, this study developed a folic acid-chitosan (FA-CS)-modified liposomal formulation co-delivering doxorubicin (DOX) and resiquimod (R848) for combined chemotherapy and immune modulation. Methods: The FA-CS-R848/DOX@Lip liposomes were prepared by rotary evaporation and characterized for morphology, particle size, zeta potential, drug encapsulation efficiency (EE), drug loading (DL) capacity, and drug release profiles. Cellular uptake and cytotoxicity were determined to assess the…

Oncology Research
Review

The Role of HPV and Hormone in Cervical Precancer and Cancer: Molecular Pathophysiology and Cell Biology of Disease and Treatment

Cervical cancer remains a major global health challenge despite advances in human papillomavirus (HPV) vaccination, screening, and treatment. Persistent infection with high-risk HPV types, particularly HPV16 and HPV18, is a necessary cause of cervical cancer; however, only a small fraction of infections progress to malignancy, indicating the importance of additional cofactors. Increasing evidence identifies estrogen signaling as a critical modifier of HPV-driven carcinogenesis. Estrogen acts synergistically with HPV oncogenes E6 and E7 to promote genomic…

Oncology Research
Review

EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives

Acral lentiginous melanoma (ALM) is characterized by a low mutational burden, frequent chromosomal rearrangements, and profound epigenetic dysregulation, distinguishing it from ultraviolet (UV)-induced melanoma. Among the epigenetic regulators, Enhancer of Zeste Homolog 2 (EZH2), the catalytic component of the Polycomb Repressive Complex 2 (PRC2), plays a central role in chromatin compaction and transcriptional repression through trimethylation of histone H3 on lysine 27 (H3K27me3). EZH2 overexpression or hyperactivation contributes to tumor progression, immune evasion, and therapeutic…

Oncology Research
Article

Clinical Value of the Systemic Immune Inflammation Index and PD-L1 Expression in Advanced NSCLC Treated with Pembrolizumab: Real-World Preliminary Study

Objective: Studies on the comprehensive utility of complete blood count-derived inflammatory biomarkers (CBC-IBs) as biomarkers in pembrolizumab-treated advanced non-small-cell lung cancer (NSCLC) are scarce. This study aimed to investigate the clinical relevance of a panel of CBC-IBs as potential predictive biomarkers and assess whether integrating the systemic immune-inflammation index (SII) with programmed death-ligand 1 (PD-L1) expression could overcome the limitations of PD-L1 as a standalone predictive biomarker. Methods: Our real-world preliminary study was conducted on a…

Oncology Research
Review

Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives

The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount substances for achieving this goal. The unique physico-chemical properties and metabolism of these compounds, as well as metals themselves, allow…

Oncology Research
Article

Ethnic Disparities in Glioblastoma Markers: Impact of Chromosome 7 Gain and 10 Loss Alterations on Clinical Survival Outcomes

Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor and is characterized by significant intratumoral heterogeneity. This study aimed to investigate the clinical and genomic landscapes of GBM across diverse ethnic populations to identify potential prognostic markers. Methods: Leveraging The Cancer Imaging Archive (TCIA) and bioinformatics modeling, White, African, and Asian American cohorts were analyzed. Patients were stratified according to the 2021 WHO classification of central nervous system (CNS) tumors. Population-specific genomic drivers and…

Oncology Research
Article

Polypharmacy in Elderly Patients Receiving First-Line Treatment for Pancreatic Adenocarcinoma: Analysis of Potential Drug–Drug Interactions and Outcome

Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality and mainly affects older adults, who frequently experience polypharmacy. While systemic therapy may improve outcomes in selected older patients, the use of multiple drugs increases the risk of potential drug–drug interactions (pDDIs). This study aimed to evaluate the prevalence and characteristics of pDDIs in older patients with PDAC receiving first-line systemic therapy and their potential impact on clinical outcomes. Methods: We conducted a retrospective…

Oncology Research
Review

Current and Future Landscape of Hepatocellular Carcinoma Treatment

Hepatocellular carcinoma (HCC) represents a critical global health challenge, standing as a leading cause of cancer mortality with a significant and projected increasing incidence worldwide. A primary hurdle in HCC management is late diagnosis, often attributable to the absence of early symptoms. Despite considerable advancements in therapeutic strategies over the past decade, including immune checkpoint inhibitors and targeted therapies, mortality rates remain high, underscoring the urgent need for more effective novel approaches. The inherent molecular…