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Extracellular Vesicles and Cancer

Submission Deadline: 30 June 2023 (closed)

Guest Editors



Professor Dr. Jafar Rezaie, Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Iran. Rezaie.j@umsu.ac.ir

Summary

Extracellular vesicles  (EVs) are phospholipid bilayer vesicles released from tumor and non-tumor cells for intercellular communication. EVs contain different types of proteins, nucleic acids, and lipids that contribute to affect target cell function and fate. Three main subclasses of EVs including exosomes, microvesicles, and apoptotic bodies have been categorized, which represent pivotal roles in cellular physiology. ‎Exosomes, 30-150 nm EVs, have dramatically fascinated the attention of researchers owing to their ‎pivotal roles in carcinogenesis and cancer treatment. Exosomes biogenesis may show a crosstalk with other signaling pathways such as autophagy, apoptosis, and P53/TSPA6 to preserve cellular hemostasis.

 

This Special Issue is dedicated to the roles of EVs in cancer progress and treatment, with specific highlighting on the role of exosomes as cell-to-cell communication mediators in cancer management.

 

Areas of interest include, but are not limited to:

• Exosomes signaling pathway in tumor cells.

• Tumor angiogenesis and exosomes/microvesicles.

• Tumor immunology and exosomes/microvesicles.

• Tumor resistance to therapies and exosomes.

• Exosomes as drug-delivery particles.

• Exosomes therapy for cancer.

• Exosomes and biomarkers for cancer.

• Crosstalk between exosomes, autophagy and apoptosis signalings 



Keywords

Extracellular vesicles; Exosomes; Tumor environment; Drug-delivery; Biomarker; Exosomes-autophagy crosstalk

Published Papers


  • Open Access

    ARTICLE

    Effects of platelets on characteristics of lymphocytes cultured in vitro and optimization of adoptive immunotherapy

    CONGLIANG CHEN, XIAOHONG LENG, YU ZHANG, JUNMEI HU, DAPENG WEI, PEIPEI WANG, XIA WANG
    BIOCELL, Vol.47, No.12, pp. 2661-2669, 2023, DOI:10.32604/biocell.2023.043084
    (This article belongs to the Special Issue: Extracellular Vesicles and Cancer)
    Abstract Background: T lymphocytes, the main participants of cellular immunity, can express a variety of surface molecules and form different lymphocyte subsets under the induction of different factors to play the functions of immune regulation and immune killing. Studies have shown that platelets play a crucial role in maintaining the stable differentiation of lymphocytes and the balance in immunomodulation. Therefore, it is necessary to study the effect of platelets on lymphocytes in vitro to better understand the role of platelets in the immune system and broaden the application of adoptive immunotherapy. Methods: Cell counting and microscopic observation were… More >

  • Open Access

    REVIEW

    The role of mesenchymal stem cell-derived exosomes in tumor progression

    CARL RANDALL HARREL, VALENTIN DJONOV, ANA VOLAREVIC, DRAGICA PAVLOVIC, VLADISLAV VOLAREVIC
    BIOCELL, Vol.47, No.8, pp. 1757-1769, 2023, DOI:10.32604/biocell.2023.028567
    (This article belongs to the Special Issue: Extracellular Vesicles and Cancer)
    Abstract Exosomes derived from mesenchymal stem cells (MSC-Exos) are nano-sized extracellular vesicles enriched with bioactive molecules, such as microRNAs, enzymes, cytokines, chemokines, immunomodulatory, trophic, and growth factors. These molecules regulate the survival, phenotype, and function of malignant and tumor-infiltrated immune cells. Due to their nano-size and bilayer lipid envelope, MSC-Exos can easily bypass biological barriers and may serve as drug carriers to deliver chemotherapeutics directly into the tumor cells. Here, we summarize current knowledge regarding molecular mechanisms responsible for MSC-Exos-dependent modulation of tumor progression and discuss insights regarding the therapeutic potential of MSC-Exos in the treatment More >

    Graphic Abstract

    The role of mesenchymal stem cell-derived exosomes in tumor progression

  • Open Access

    ARTICLE

    Changes in intracellular and extracellular proteins after ERGIC3 knockdown in lung cancer: Proteins interacting with ERGIC3, HORN, and FLNA

    WEI ZHAI, XIANG ZHENG, MENGYUAN LIU, QIURONG ZHAO, YUSHU ZHANG, YUQING LUO, SHANSHAN FENG, JINJING WANG, XUEYING LI, MINGSONG WU
    BIOCELL, Vol.47, No.8, pp. 1821-1833, 2023, DOI:10.32604/biocell.2023.027175
    (This article belongs to the Special Issue: Extracellular Vesicles and Cancer)
    Abstract Objective: Endoplasmic reticulum-Golgi intermediate compartment 3 (ERGIC3) promotes cell proliferation and metastasis in lung cancer, but its molecular mechanism is unclear. Methods: The GLC-82 cells were randomly divided into the ERGIC3i group and the negative control group. The cells were transfected with ERGIC3 siRNA or control siRNA in the groups, respectively. The ERGIC3-interacting proteins expressed in cells or extracellularly were isolated by the immunoprecipitation method and detected by isobaric tags for relative and absolute quantitation and liquid chromatography-tandem mass spectrometry. The differentially expressed proteins were determined by bioinformatic methods. Results: After ERGIC3 knockdown, 88 extracellular differentially… More >

  • Open Access

    REVIEW

    Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer

    MOHADESEH NEMATI, YOUSEF RASMI, JAFAR REZAIE
    BIOCELL, Vol.47, No.3, pp. 455-464, 2023, DOI:10.32604/biocell.2023.025603
    (This article belongs to the Special Issue: Extracellular Vesicles and Cancer)
    Abstract Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer death globally. Resistance to therapy is a challenge for CRC treatment. Mesenchymal stem cells (MSCs) have become one of the furthermost effective approaches for tumor treatment due to their specific feature; however, their therapeutic function is controversial. Recently, extracellular vesicles (EVs) derived from MSCs (MSCs-EVs) have attracted extensive research attention due to their promising role in CRC treatment. EVs are cell-derived vesicles that transfer different biomolecules between cells, contributing to intracellular communication. MSCs-EVs can suppress CRC by delivering therapeutic agents… More >

  • Open Access

    ARTICLE

    Exosomes: Key tools for cancer liquid biopsy

    ISABELLA PANFOLI, MAURIZIO BRUSCHI, GIOVANNI CANDIANO
    BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154
    (This article belongs to the Special Issue: Extracellular Vesicles and Cancer)
    Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the… More >

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