Open Access
REVIEW
Joaquin Cabrera1,2, Paula Mariela González1,2, Susana Puntarulo1,2
BIOCELL, Vol.43, No.2, pp. 41-50, 2019, DOI:10.32604/biocell.2019.06163
Abstract Degraded water quality from nutrient pollution, physical, biological, and other chemical factors contributes
to the development and persistence of many harmful algal blooms (HABs). The complex dynamics of the HABs is
a challenge to marine ecosystems for the toxic effects reported. The consequences include fish, bird, and mammal
mortality, respiratory or digestive tract problems, memory loss, seizures, lesions and skin irritation in many organisms.
This review is intended to briefly summarize the recent reported information on harmful marine toxin deleterious
effects over the primary organisms of the food web, namely algae, zooplankton and invertebrates. Special focus is made
on oxidative… More >
Open Access
ARTICLE
Hala Abdulaziz M ALWARTHAN1, Mohammad Saud AL ANAZI1, Narasimha R. PARINE1, Ramesa Shafi BHAT1,*, Ghadah ALAMRO1, Ftoon ALJARBOU1, Sooad K AL-DAIHAN1
BIOCELL, Vol.43, No.2, pp. 51-58, 2019, DOI:10.32604/biocell.2019.07019
Abstract Tankyrase1 plays an essential role in cancer progression by regulating telomere length. The study aimed
to determine expression of TNKS1 and its regulation in colorectal cancer (CRC) in 20 samples from Saudi patients.
mRNA expression of TNKS1 in CRC and paired normal tissues was measured by qRT-PCR. Epigenetic modification
of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger
sequencing in exon 10 of the gene. All cancerous and normal tissues expressed TNKS1, but level of expression in CRC
tissues was significantly associated with tumor stage though no other parameters; age, gender, and tumor location,… More >
Open Access
ARTICLE
HAIFENG WANG1,2, KAI WANG1, JUAN GUO1, TIEQIAO WEN2
BIOCELL, Vol.43, No.2, pp. 59-64, 2019, DOI:10.32604/biocell.2019.05731
Abstract Histone deacetylation is a key modulator involved in cell proliferation, apoptosis, and mRNA transcription.
However, the effects of histone deacetylation on C17.2 neural stem cells (NSCs) remain unclear. Here, the histone
deacetylase inhibitors nicotinamide and trichostatin A (TSA) were used to determine the role of histone deacetylation
on gene transcription in NSCs. The results showed that the mRNA expression of p53, Sox1, Sox2, and Bax were
significantly higher in E14.5 NSCs than in C17.2 NSCs. Nestin, a marker gene of neuronal differentiation, did not differ
significantly between E14.5 NSCs and C17.2 NSCs. The transcription levels of p53 and Nestin were… More >
Open Access
ARTICLE
Ramesa Shafi BHAT1, Amina El GEZEERY2, Abir Ben BACHAN1, Mona Awad ALONAZI1, Leena Saleh ALSUHAIBANI1, Afaf El-ANSARY3,4
BIOCELL, Vol.43, No.2, pp. 65-71, 2019, DOI:10.32604/biocell.2019.07012
Abstract Fluoride is a key ingredient of many psychiatric drugs like fluoxetine (Prozac®, Fluoxetine®). Pregnant women
frequently use this drug as they suffer from depression and anxiety disorders during this period. Fluoxetine is able to
reach the fetus through the placenta and passes to the newborn through milk. In the present study, female Wistar rats
were treated with 5, 10, and 20 mg/L fluoxetine (containing 94% fluorides) from pregnancy day 10 to day 20. After
delivery, the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were measured. The
results showed that, in all fluoxetine… More >
Open Access
ARTICLE
Entsar A. SAAD1, Reda S. EL-DEMERDASH2, Eman M. ABD EI-FATTAH1
BIOCELL, Vol.43, No.2, pp. 73-80, 2019, DOI:10.32604/biocell.2019.07020
Abstract Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to
evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction
of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10
(IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal
kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney
function tests. Rats treated with cisplatin + captopril showed noticeable kidney histopathological changes. Superior… More >
Open Access
ARTICLE
Mahmoud MOUSTAFA1,2, Saad ALAMRI1, Hoida ZAKI2, Naglaa LOUTFY2, Tarek TAHA3, Ali SHATI1, Mohamed ALKAHTANI1, Sajda SIDDIQI1
BIOCELL, Vol.43, No.2, pp. 81-88, 2019, DOI:10.32604/biocell.2019.06231
Abstract The present research reports of quick and marked changes induced by plant extract of Euryops arabicus in the
gene expression of 49-kDa apyrases, cytoskeletal proteins, ATPases, ADPase and amount of amino acid of pea (Pisum
sativum L. var. Alaska). Pellets of cytoskeletals proteins (27000 xg) were probed with anti-apyrase antibody, biotinylated
anti-rat, actin and alpha and beta-tubulin for Western blotting. ATPase and ADPase activities were determined based
on the hydrolytic efficacy of adenine triphosphate and adenine diphosphate. By 72 hours, the abundance of apyrases,
cytoskeletal proteins and amount of amino acid in pellets of 27000 xg of germinated pea seeds… More >
Open Access
ARTICLE
Xiaoning Qin1, Liqing Yuan2, Hongxun Ruan1, Lin Lin1
BIOCELL, Vol.43, No.2, pp. 89-98, 2019, DOI:10.32604/biocell.2019.06352
Abstract Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells
predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between
elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung
diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains
elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues
have more active expression of IL-22 and IL-22R1 than normal tissues, presenting correlation with the degree of… More >
Open Access
ARTICLE
Zongqiang GAO1, Xiong GUO2, Junchang CHEN1, Chen DUAN2
BIOCELL, Vol.43, No.2, pp. 99-102, 2019, DOI:10.32604/biocell.2019.06520
Abstract This study aimed to investigate the effect of hyaluronic acid (HA) on the expression of heat shock protein
70 (HSP70) in chondrocytes isolated from patients with osteoarthritis (OA) and Kashin-Beck disease (KBD). The
chondrocytes were collected from OA and KBD patients, and chondrocytes isolated from patients of accident injuries
were used as the control. The chondrocytes were treated with HA at different doses. HSP70 expression in chondrocytes
at both mRNA and protein levels was tested by PCR and Western blot analysis. Compared with control, both mRNA
and protein levels of HSP70 were higher in chondrocytes from KBD and OA. However,… More >
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