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REVIEW
SUBHASH CHANDRA1,2, SANTWANA PALAI3, EDINARDO FAGNER FERREIRA-MATIAS4, IVO CAVALCANTE PITA-NETO4, CíCERO LUCAS GOMES-RAMALHO4, EDLANE MARTINS DE ANDRADE4, RAY SILVA DE ALMEIDA5, MARCELLO IRITI6,7,*, HENRIQUE DOUGLAS MELO-COUTINHO5,*
BIOCELL, Vol.47, No.4, pp. 677-695, 2023, DOI:10.32604/biocell.2023.026081
（This article belongs to this Special Issue: Antimicrobial Resistance: From Basic Science to Applied Approaches)
Abstract Indian medicinal plants are referred to as the “nectar of life” owing to their phytochemicals and bioactive complexes that are beneficial in treating diseases. Coronavirus disease 2019 (COVID-19) is a global health issue without any proper medication. The indigenous plants of India can be exploited to control the precise signs of SARS-CoV-2. The Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy) has advised routine usage of medicinal plants for COVID-19. Medicinal plants like Zingiber officinalis, Azadirachta indica, Ocimum sanctum, Nigella sativa, Withania somnifera, Curcuma longa, Piper nigrum, Allium sativum, Tinospora cordifolia, etc. have immunity-boosting, antiviral, antibacterial, antioxidant… More >
Open Access
REVIEW
JIA LIU1,2,#, FAPING WANG1,2,#, BO YUAN3, FENGMING LUO1,2,*
BIOCELL, Vol.47, No.4, pp. 697-705, 2023, DOI:10.32604/biocell.2023.026148
（This article belongs to this Special Issue: Bioinformatics Study of Diseases)
Abstract Runt-related transcription factor-1 (RUNX1), also known as the core-binding factor alpha 2 subunit, is closely related to human leukemia. The functions of RUNX1 in modulating cell proliferation, differentiation, and survival in multiple systems have been gradually discovered with the emergence of transgenic mice. RUNX1 is a powerful transcription factor implicated in diverse signaling pathways and cellular mechanisms that participate in lung development and pulmonary diseases. RUNX1 has recently been identified as a target regulator of fibrotic remodeling diseases, particularly in the kidney. However, the role of RUNX1 in pulmonary fibrosis is unclear. Pulmonary fibrosis is characterized by obscure nosogenesis, limited… More >
Open Access
REVIEW
PRIYANKA SOLANKI1, NISARG RANA1, PRAKASH C. JHA2, ANU MANHAS1,*
BIOCELL, Vol.47, No.4, pp. 707-729, 2023, DOI:10.32604/biocell.2023.026615
（This article belongs to this Special Issue: Bioinformatics Study of Diseases)
Abstract Cancer is considered one of the most lethal diseases responsible for causing deaths worldwide. Although there have been many breakthroughs in anticancer development, cancer remains the major cause of death globally. In this regard, targeting cancer-causing enzymes is one of the efficient therapeutic strategies. Biological functions like cell cycle, transcription, metabolism, apoptosis, and other depend primarily on cyclin-dependent kinases (CDKs). These enzymes help in the replication of DNA in the normal cell cycle process, and deregulation in the functioning of any CDK can cause abnormal cell growth, which leads to cancer. This review is focused on anticancer drug discovery against… More >
Open Access
VIEWPOINT
KAMILA CZUBAK-PROWIZOR*, MARIA SWIATKOWSKA
BIOCELL, Vol.47, No.4, pp. 731-737, 2023, DOI:10.32604/biocell.2023.025677
Abstract Junctional adhesion molecule-A (JAM-A), also known as the F11 receptor (F11R), is one of the tight junction components. JAM-A is a transmembrane glycoprotein that regulates many cellular processes, i.e., angiogenesis, leukocyte transendothelial migration, intercellular permeability, epithelial-to-mesenchymal transition, and platelet activation. Of note, it is involved in the pathogenesis of various cancer types, including gynecological cancers. Only a few studies are available about this cancer type. Observed aberrant JAM-A expression in gynecological cancers correlates with poor patient prognosis. To the best of our knowledge, conflicting JAM-A roles in various cancer types suggest that its involvement is complex and tumor-type specific. The… More >
Open Access
REVIEW
JIAWEI FU1,2,3,#, CHUNSHUAI WU1,2,3,#, GUANHUA XU1,2,3, JINLONG ZHANG1, YIQIU LI1, CHUNYAN JI1,2,3, ZHIMING CUI1,2,3,*
BIOCELL, Vol.47, No.4, pp. 739-749, 2023, DOI:10.32604/biocell.2023.026881
（This article belongs to this Special Issue: Neuroimmune Interactions at the Crossroads of Health and Disease)
Abstract Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists of receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like protein, is believed to control a novel type of programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural cell damage, release of intracellular pro-inflammatory factors, lysosomal dysfunction and endoplasmic reticulum stress. Recent research indicates that necroptosis is crucial to the… More >
Open Access
REVIEW
LAKSHANA SADU#, R.HARI KRISHNAN#, R.L. AKSHAYA, I. SARANYA, UDIPT RANJAN DAS, SNEHA SATISHKUMAR, N. SELVAMURUGAN*
BIOCELL, Vol.47, No.4, pp. 751-760, 2023, DOI:10.32604/biocell.2023.026911
（This article belongs to this Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
Abstract MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate the expression of their target mRNAs
post-transcriptionally. Since their discovery, thousands of highly conserved miRNAs have been identified and investigated
for their role in human health and diseases. MiR-214 has been increasingly reported to have an association with the
regulation of bone metabolism. Reports suggested that miR-214 controls the critical aspects of osteoblasts (bone-forming
cells), including their differentiation, proliferation, viability, and migration. Studies have also reported the functional
significance of miR-214 in bone diseases and suggested its candidature as a diagnostic and therapeutic target. Further,
targeting miR-214 by other ncRNAs, such… More >
Open Access
REVIEW
QIAO ZHOU1,2,3, JIAN LIU2,4, LING XIN4, YANYAN FANG2,4, LEI WAN2,4, DAN HUANG2,4, JINCHEN GUO1, JIANTING WEN2,4
BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698
（This article belongs to this Special Issue: Biochemical and Epigenetics Changes in Health and Disease)
Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age,
environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not
adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and
crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental
risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has
been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease… More >
Open Access
REVIEW
JINGYAO XU1,#, SHUANGLI HAO1,#, KAIYUE HAN1,#, WANXI YANG1,*, HONG DENG2,*
BIOCELL, Vol.47, No.4, pp. 773-788, 2023, DOI:10.32604/biocell.2023.026618
Abstract As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer patients, most deaths are caused by the growth of metastatic tumors outside the primary focus. Therefore, migration and invasion in the late stage of tumor progression are the main unresolved issues in the study of tumor pathogenesis, and AKT/mTOR has been found to participate in the migration and invasion of cancer cells, which means that the study of this pathway may contribute to a solution for the problem. Because of… More >
Open Access
REVIEW
AAYUSHI RANDHAWA1,2, SAYAN DEB DUTTA1, KEYA GANGULY1, TEJAL V. PATIL1,2, RACHMI LUTHFIKASARI1, KI-TAEK LIM1,2,*
BIOCELL, Vol.47, No.4, pp. 789-808, 2023, DOI:10.32604/biocell.2023.026217
（This article belongs to this Special Issue: Cell-Based Regenerative Therapies)
Abstract Tissues are made up of cells and the extracellular matrix (ECM) which surrounds them. These cells and tissues are actively adaptable to enduring significant stress that occurs in daily life. This astonishing mechanical stress develops due to the interaction between the live cells and the non-living ECM. Cells in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells, including growth, proliferation, and differentiation. However, the matrix’s characteristic features also impact the repair and regeneration of the… More >
Open Access
REVIEW
KANWAL REHMAN1, AMMARA AFZAAL2, MUHAMMAD SAJID HAMID AKASH2,*, MUHAMMAD IMRAN3,4, MOHAMMED A. ASSIRI3,4
BIOCELL, Vol.47, No.4, pp. 809-823, 2023, DOI:10.32604/biocell.2023.025850
（This article belongs to this Special Issue: Cell-Based Regenerative Therapies)
Abstract The cytokine channel’s mechanism for self-regulation involves the application of antagonistic cytokines that are synthesized to connect to the receptors and release soluble cytokine receptors. The very first receptor antagonist of cytokine that was naturally present was interleukin-1 receptor antagonist (IL-1Ra). The IL-1Ra protein forms are disinfected from supernatants of cultured monocytes on stacked IgG. The family of IL-1 consists of IL-1α, IL-1β and IL-1Ra. Human monocytes regulate the production of IL-Ra. IL-Ra takes part in normal physiological functions by using specific antibodies, and acts as an anti-inflammatory agent. IL-Ra is synthesized in the tissues during the period of active… More >
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