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Non-Coding RNAs in the Regulation of Human Cancers

Submission Deadline: 01 July 2023 (closed)

Guest Editors

Prof. Lei Yang,
Department of Orthopedics, Nanjing Medical University, Nanjing, China
leiyang@njmu.edu.cn

Prof. Athanasios E. Athanasiou,
Department of Medical Oncology, Metaxa Cancer Hospital, Botassi 51, 18537, Piraeus, Greece
editorial_office@jbuon.com

Prof. Francesco Busardò,
University Politecnica delle Marche, Ancona, Italy
f.busardo@univpm.it


Summary

Non-Coding RNAs (ncRNAs) are RNA molecules transcribed from the genome that do not encode proteins, and can be divided into small noncoding RNAs (snRNAs, snoRNAs, miRNAs, and piRNAs) and long noncoding RNAs (>200 nucleotides). More and more evidence have demonstrated the important role of ncRNAs in the physiological and pathological processes of human cancers. Due to the wide variety of ncRNAs and their mechanisms of action, it is a difficult task to understand how changes in ncRNA expression promote the progression of cancer. In addition, changes in ncRNA expression levels are usually cancer-specific or even subtype-specific, which makes the wide application of research results challenging. Nevertheless, an in-depth understanding of the nuances of ncRNA regulation provides more opportunities for new therapeutic targets. The main aim of this special issue is to further understand the mechanism of ncRNAs and their influences on the signaling network of cancers in order to develop better prognosis and treatment strategies.

 

This special issue on the “Non-Coding RNAs in the Regulation of Human Cancers” welcomes interesting articles as well as reviews that focus on the emerging important role of non-coding RNAs in the diagnosis and treatment of kinds of cancers.

 

Areas of interest include, but are not limited to:

1) The molecular mechanism of miRNAs in the occurrence and development of human cancers;

2) The molecular mechanism of lncRNAs in the occurrence and development of human cancers;

3) The molecular mechanism of circRNAs in the occurrence and development of human cancers;

4) The molecular mechanism of snRNAs in the occurrence and development of human cancers;

5) The molecular mechanism of , snoRNAs in the occurrence and development of human cancers;

6) The molecular mechanism of , piRNAs in the occurrence and development of human cancers;

7) Biological functions of ncRNAs combined with exosomes in human cancers;

8) Bioinformatics of ncRNAs in human Cancers;

9) Systematic review and Meta-analysis of ncRNAs in human Cancers;

10) The role of ncRNAs in the therapeutic effects and prognosis of human Cancers.


Keywords

Non-Coding RNAs, Diagnosis, Cancer, Biomarker, Therapeutics

Published Papers


  • Open Access

    MiR-19a-3p/PTEN axis regulates the anticancer effect of circHIAT1 in breast cancer in vitro

    CHAO NIU, RUOFEI SUN, XIAOGANG LI, BO LI, XIAODONG HE
    BIOCELL, Vol.47, No.10, pp. 2301-2312, 2023, DOI:10.32604/biocell.2023.029935
    (This article belongs to the Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract Objective: Breast cancer is a major cancer threatening the health of women globally. To elucidate the effect of the circHIAT1/miR-19a-3p/phosphatase and tensin homolog (PTEN) axis on regulating the malignant phenotype of breast cancer cells. Methods: The mRNA expression pattern of circHIAT1, miR-19a-3p, and PTEN was checked by real-time quantitative polymerase chain reaction. Then, the knockdown assay was carried out to explore the effect of circHIAT1 and miR-19a-3p on breast cancer. The relative cell experiments, including MTT assay, scratch assay, transwell invasion assay, and flow cytometry analysis, were conducted to verify the influence of circHIAT1 and miR-19a-3p on breast cancer cells.… More >

  • Open Access

    ARTICLE

    Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation

    JIAZHUANG LI, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU
    BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860
    (This article belongs to the Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

  • Open Access

    ARTICLE

    MiR-520f-3p inhibits epithelial-mesenchymal transition of colorectal cancer cells by targeting Yes-associated protein 1

    LIJUN JIANG, WENMIN JI, YAJIE GONG, JIAJUN LI, JINCHUN LIU
    BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516
    (This article belongs to the Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p levels were determined using… More >

    Graphic Abstract

    MiR-520f-3p inhibits epithelial-mesenchymal transition of colorectal cancer cells by targeting Yes-associated protein 1

  • Open Access

    REVIEW

    Roles of miR-214 in bone physiology and disease

    LAKSHANA SADU, R.HARI KRISHNAN, R.L. AKSHAYA, I. SARANYA, UDIPT RANJAN DAS, SNEHA SATISHKUMAR, N. SELVAMURUGAN
    BIOCELL, Vol.47, No.4, pp. 751-760, 2023, DOI:10.32604/biocell.2023.026911
    (This article belongs to the Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that regulate the expression of their target mRNAs post-transcriptionally. Since their discovery, thousands of highly conserved miRNAs have been identified and investigated for their role in human health and diseases. MiR-214 has been increasingly reported to have an association with the regulation of bone metabolism. Reports suggested that miR-214 controls the critical aspects of osteoblasts (bone-forming cells), including their differentiation, proliferation, viability, and migration. Studies have also reported the functional significance of miR-214 in bone diseases and suggested its candidature as a diagnostic and therapeutic target. Further, targeting miR-214 by other ncRNAs, such… More >

  • Open Access

    ARTICLE

    MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

    LIJUN DU, KAIKAI DOU, NIANHAI LIANG, JIANMIN SUN, RU BAI
    BIOCELL, Vol.47, No.3, pp. 547-554, 2023, DOI:10.32604/biocell.2023.025048
    (This article belongs to the Special Issue: Non-Coding RNAs in the Regulation of Human Cancers)
    Abstract Background: The Warburg effect is considered as a hallmark of various types of cancers, while the regulatory mechanism is poorly understood. Our previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor (IGF1R). In this study, we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer cells. Methods: The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus infection. ATP generation, glucose uptake, lactate production and extracellular acidification rate (ECAR) assay were used to analyze the effects of aerobic glycolysis in ovarian cancer… More >

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