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REVIEW

Anton Tkachenko^*
BIOCELL, Vol.49, No.5, pp. 721-741, 2025, DOI:10.32604/biocell.2025.063301 - 27 May 2025
Abstract Ferroptosis is an iron-driven, phospholipid hydroperoxide-mediated cell death, which has recently emerged as an attractive tool in cancer research due to its ability to govern the anti-tumor immune response. A growing research interest in ferroptosis biology has revealed the contribution of this regulated cell death to multiple diseases. In addition to iron, ferroptosis has been reported to be triggered by multiple heavy metals, which sheds light on the novel aspects of heavy metals-induced cytotoxicity. In this review, the ability of zinc, an essential biogenic element with a wide array of biological functions, to modulate ferroptosis… More >

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443

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Dmitriy Vladimirovich Karpenko^*
BIOCELL, Vol.49, No.5, pp. 743-765, 2025, DOI:10.32604/biocell.2025.062791 - 27 May 2025
（This article belongs to the Special Issue: Exploring the Role of Cancer Stem Cells)
Abstract Cancer is a highly heterogeneous pathology that poses a significant threat to millions of lives worldwide. In recent decades, there has been a substantial advancement in our understanding of the mechanisms underlying oncogenesis. Contemporary models now take into account the intricate interplay between cancer cells, immune cells, and other non-pathological cells during oncogenesis. The identification of small subpopulations of cancer stem cells has emerged as a crucial area of research, as these cells have been associated with cancer progression and resistance to various therapeutic interventions. The ability to distinguish between cancer stem cells and non-pathological… More >

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485

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CARLOS ALFONSO FLORES-GUTIéRREZ¹, ERANDIS DHENI TORRES-SáNCHEZ¹, EMMANUEL REYES-URIBE¹, JUAN HERIBERTO TORRES-JASSO², JOEL SALAZAR-FLORES^1,*
BIOCELL, Vol.49, No.5, pp. 767-787, 2025, DOI:10.32604/biocell.2025.062225 - 27 May 2025
Abstract Pesticides are chemical substances used to eliminate various pests. Currently, more than two million tons of pesticides are used annually in developing and developed countries. One of the chronic diseases associated with pesticide poisoning is diabetes. This review aimed to elucidate the mechanisms of action involved in the development of diabetes after pesticide poisoning. Relevant information was collected between January and May 2024, using databases such as PubMed, Google Academic, and Elsevier. Pesticides reduce the secretion of glucagon-like peptide-1 (GLP-1) in the intestine, thereby decreasing the release of insulin. Moreover, pesticides are metabolized to acetic More >

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1014

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425

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REVIEW

Iman Ezzat, Marisa Zallocchi^*
BIOCELL, Vol.49, No.5, pp. 789-811, 2025, DOI:10.32604/biocell.2025.062325 - 27 May 2025
（This article belongs to the Special Issue: Extracellular Matrix in Development and Disease)
Abstract Integrins are heterodimeric transmembrane receptors that mediate bidirectional interactions between the intracellular cytoskeletal array and the extracellular matrix. These interactions are critical in tissue development and function by regulating gene expression and sustaining tissue architecture. In humans, the integrin family is composed of 18 alpha (α) and 8 beta (β) subunits, constituting 24 distinct αβ combinations. Based on their structure and ligand-binding properties, only a subset of integrins, 8 out of 24, recognizes the arginine-glycine-aspartate (RGD) tripeptide motif in the native ligand. One of the major RGD binding integrins is integrin alpha 8 beta 1 More >

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451

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Xiaobing Li^1,2, Yongsheng Liu¹, Limin Wei¹, Li Rao¹, Jingxin Mao^1,*, Xuemei Li^3,*
BIOCELL, Vol.49, No.5, pp. 813-832, 2025, DOI:10.32604/biocell.2025.062124 - 27 May 2025
Abstract Yeast-based models have become a powerful platform in pharmaceutical research, offering significant potential for producing complex drugs, vaccines, and therapeutic agents. While many current drugs were discovered before fully understanding their molecular mechanisms, yeast systems now provide valuable insights for drug discovery and personalized medicine. Recent advancements in genetic engineering, metabolic engineering, and synthetic biology have improved the efficiency and scalability of yeast-based production systems, enabling more sustainable and cost-effective manufacturing processes. This paper reviews the latest developments in yeast-based technologies, focusing on their use as model organisms to study disease mechanisms, identify drug targets,… More >

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636

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MINGZHI LUO^#,*, CHANGYU SUN^#, JIA GUO, XIANGRONG ZHANG, JING ZHANG, XUANYU SHI, LEI LIU, YAN PAN, JINGJING LI, LINHONG DENG^*
BIOCELL, Vol.49, No.5, pp. 833-855, 2025, DOI:10.32604/biocell.2025.063869 - 27 May 2025
Abstract Background: Mechanical ventilation (MV) provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury (VILI). However, due to a poor understanding of its mechanism, there is still a lack of effective remedies for the often-deadly VILI. Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles (EVs) and induce endoplasmic reticulum (ER) stress in airway smooth muscle cells (ASMCs), both of which can contribute to VILI. But whether MV-associated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying… More >

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Chieh-Jen Wu^1,#, Yu-He Li^2,#, Hsin-Hung Chen^3,*
BIOCELL, Vol.49, No.5, pp. 857-872, 2025, DOI:10.32604/biocell.2025.064071 - 27 May 2025
（This article belongs to the Special Issue: Heart-Kidney Interactions: Mechanisms in Metabolic Dysfunction and Organ Injury)
Abstract Background: Serum- and glucocorticoid-induced kinase 1 (SGK1) is a member of the serine/threonine kinase family, playing a crucial role in regulating ion channel function, hormone secretion, cellular growth, survival mechanisms, and neuronal activity. SGK1 is implicated in kidney diseases, hypertension, and metabolic syndromes, influencing salt intake, renal growth, and renal potassium (K⁺) excretion during mineralocorticoid overdose. Although SGK1’s renal functions have been explored, comprehensive identification of SGK1-related genes and signaling cascades remains limited. Objectives: This research sought to explore the cellular mechanisms and signaling pathways influenced by SGK1 in rat kidney cells. Methods: NRK-52E cells, derived… More >

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315

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ARTEM P. GUREEV¹, IRINA S. SADOVNIKOVA¹, EKATERINA V. CHERNYSHOVA¹, EKATERINA P. KRUTSKIKH¹, IRINA B. PEVZNER², LJUBAVA D. ZOROVA², VERONIKA V. NESTEROVA¹, POLINA I. BABENKOVA¹, EGOR Y. PLOTNIKOV^2,*
BIOCELL, Vol.49, No.5, pp. 873-892, 2025, DOI:10.32604/biocell.2025.063557 - 27 May 2025
（This article belongs to the Special Issue: Autophagy and Aging: Mechanisms and Implications)
Abstract Background: Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease (AD). Resveratrol is a promising compound for the treatment of various neurodegenerative diseases, including AD. Aims: To investigate mitochondrial damage and the effects of resveratrol on inflammation, cognitive function, and mitochondrial quality control in APP/PS1 mice. Methods: Comparative analysis of mitochondrial DNA (mtDNA) damage was conducted between 10-month-old APP/PS1 mice and age-matched C57BL/6 mice. Assessments included measurement of amyloid-β levels, inflammatory markers, swimming distance in the Morris water maze, and gut microbiome composition. Resveratrol’s effects on cytokine expression, mtDNA levels in plasma, and… More >

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328

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MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*
BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025
（This article belongs to the Special Issue: Cellular and Molecular Mechanisms Underlying Inflammation and Immune Regulation: From Genotoxicity to Apoptosis)
Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

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489

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257

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Qi Guo¹, Jianxiong Xu^2,*, Xuan Cai², Jiaojiao Xie¹, Siqi Wu¹
BIOCELL, Vol.49, No.5, pp. 907-924, 2025, DOI:10.32604/biocell.2025.063568 - 27 May 2025
Abstract Objectives: Weaning induces oxidative stress in pigs, increasing the risk of diarrhea and death. Intestinal damage is associated with obstructed intestinal cell cycles. To stop damage caused by reactive oxygen species (ROS), N-acetyl cysteine (NAC) has been widely employed. In this study, we examined changes in the intestinal cyclin of weaning piglets and assessed the impact of NAC on intestinal cell cycle arrest and intracellular signaling pathways. Methods: We conducted two animal experiments. In the first, we divided 12 litters of 120 newborn piglets into two groups: a control group and a weaning group. The… More >

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