Sabghatullah Ghorzang^1,2,*, İhsan Karlı^1,*

Journal of New Media, Vol.7, pp. 1-16, 2026, DOI:10.32604/jnm.2026.076922 - 24 March 2026

Abstract In the rapidly evolving digital landscape, the interplay between social media and cultural identity among Afghan youth is of growing significance. This study examines how social media influences the digital culture of Afghan youth, using Social Identity Theory (SIT) to explore digital behaviors, identity formation, and cultural preservation. With a sample of 400 participants, the research addresses key gaps by analyzing the impact of social media on societal norms, cultural values, and online relationships. The findings highlight social media’s pivotal role in shaping Afghan digital culture, with a particular emphasis on the active engagement of More >

Long Li, Hengyang Wu^*, Na Wang

Journal on Artificial Intelligence, Vol.8, pp. 169-182, 2026, DOI:10.32604/jai.2026.077462 - 23 March 2026

Abstract Zero-shot learning as an emerging approach in image captioning techniques, has garnered significant attention from researchers in recent years due to its ability to accomplish tasks without requiring specific category training data. Existing zero-shot image captioning schemes largely rely on traditional language models, which exhibit low efficiency and suboptimal generation quality. To address this issue, this study proposes Hamiltonian Monte Carlo for Image Captioning (HMCIC). This method first models the image captioning task as a probabilistic sampling problem in parameter space, integrating semantic matching and syntactic coherence into an energy function to guide the generation… More >

Yuanhong Mao^#, Yunlan Yang^#, Kun Yang^§, Yongqiang Sun, Kun Yang^*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.075138 - 23 March 2026

Abstract Objective: Intestinal barrier disruption is a critical event in sepsis and ischemia–reperfusion (I/R) injury. Enteric glial cells (EGCs) maintain barrier integrity by secreting glial cell line–derived neurotrophic factor (GDNF). This study aimed to determine whether Dexmedetomidine (Dex) protects the intestinal barrier via α7-nicotinic acetylcholine receptor (α7-nAChR) signaling in EGCs. Methods: An in vitro EGC-intestinal epithelial cell (IEC) co-culture system and a murine intestinal I/R model were established. EGCs were selectively ablated in vivo using benzalkonium chloride (BAC). Barrier integrity was evaluated by transmembrane electrical resistance (TEER) and plasma FITC-dextran permeability. Enzyme-Linked Immunosorbent Assay (ELISA) and Western blotting… More >

Gerardo Ramírez-Mejía^1,#, Sofía Plata-Burgos^1,#, Raquel Cuevas-Díaz Duran², Adrian Ledesma-Beiza¹, Cynthia Sámano¹, Thalía Estefanía Sánchez-Correa³, Ernesto Soto-Reyes^1,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.075061 - 23 March 2026

Abstract Objectives: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation. Brother of the Regulator of Imprinted Sites (BORIS/CTCFL) has been implicated in oncogenic transcriptional programs in several cancers, but its role in GBM remains poorly defined. This study aimed to characterize BORIS-associated transcriptional programs in GBM and to assess their functional relevance using integrative computational and experimental approaches. Methods: Transcriptomic data from The Cancer Genome Atlas (TCGA)-GBM and Genotype-Tissue Expression (GTex) brain cortex were analyzed following batch correction, differential expression analysis, and gene ontology enrichment. TCGA-GBM samples were… More >

Abdullah Alattar¹, Reem Alshaman¹, Fawaz E. Alanazi¹, Yusuf S. Althobaiti², Ghareb M. Soliman³, Waleed Salman Khubrni¹, Howaida S. Ali⁴, Fawad Ali Shah^5,6,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.074865 - 23 March 2026

Abstract Objectives: Permanent middle cerebral artery occlusion (pMCAO) can lead to hippocampal damage through multiple linked pathways such as reactive oxidative stress (ROS), neuroinflammation mediated by NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), tumour necrosis factor-alpha (TNF-α), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and glutamate excitotoxicity involving N-methyl-D-aspartate receptor subunits 2a and 2b (NR2a/NR2b) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR/GluR1). The hippocampus, which is essential for memory and cognition, is at a substantial risk of ischemic degeneration. The aim of this study was to investigate the neuroprotective potential of melatonin in regulating these… More > Graphic Abstract

Semin Lee^1,2,#, Minjun Kim^3,4,#, Seungmin Lee^2,5, Jiyun Yoo^1,5, Soo Seok Hwang^6,7, Seongchan Kim⁸, Seung Pil Yun^9,10, Dong Kyu Choi^11,12,*, Sangdun Choi^13,14,*, Hyuk-Kwon Kwon^1,2,5,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.074555 - 23 March 2026

Abstract Objective: Cisplatin is a widely used chemotherapeutic agent due to its ability to damage DNA in the treatment of cancer. However, its clinical application is often limited by adverse effects on normal tissues, especially the kidneys. Understanding the molecular mechanisms of cisplatin-induced nephrotoxicity is crucial for developing strategies to mitigate its side effects. In this study, we aimed to elucidate the molecular mechanisms underlying cisplatin-induced DNA damage and apoptosis in human renal epithelial cells, with a focus on key signaling pathways and mediators that drive nephrotoxicity. Methods: To explore these mechanisms, human proximal tubule epithelial… More >

Alessio L. Ravani¹, Michael I. Bukrinsky², Anastasia V. Poznyak^3,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.074266 - 23 March 2026

Abstract Atherosclerosis (AS) remains a major contributor to cardiovascular disease (CVD) mortality worldwide. Its development involves dysregulated lipid handling, persistent vascular inflammation, and endothelial cell (EC) dysfunction, influenced by genetic, environmental, and lifestyle factors. Increasing evidence highlights a pivotal role of endoplasmic reticulum (ER) stress as a molecular link between lipid dysregulation and inflammatory signaling in AS pathogenesis. ER stress is triggered by modified LDL, oxidized lipids, hyperhomocysteinemia, oxidative stress (OS), and disrupted calcium (Ca²⁺) homeostasis, leading to activation of the unfolded protein response (UPR). Core UPR mediators—inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like ER kinase (PERK),… More >

Huan Zhou¹, Jiami Jiang², Yuqing Zou¹, Jiahui Zhang^1,*, Zhiwei Yu^3,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.073989 - 23 March 2026

Abstract Obesity-related asthma is a distinct clinical phenotype, characterized by severe respiratory symptoms, reduced responsiveness to conventional glucocorticoid therapy, and a significantly increase in disease burden. With the rising global prevalence of obesity, the number of individuals affected by obesity-related asthma is steadily growing, presenting a pressing public health issue. The pathogenesis of obesity-related asthma is multifactorial, involving a complex interplay of metabolic and immune pathways. Key mechanisms include dysregulated T-cell differentiation, pro-inflammatory macrophage polarization, oxidative stress, and altered cytokines and adipokines secretion, all contributing to airway inflammation and remodeling. Additionally, metabolic factors, such as adiposity… More >

Jingfei Shi^#, Yi Ding^#, Hui Lu^*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.073956 - 23 March 2026

Abstract Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Soluble interleukin-2 receptor alpha (sIL-2Rα) has been implicated in MS pathogenesis, but its mechanisms remain unclear. This study investigates how sIL-2Rα exacerbates MS by modulating microglial activation and antibody-dependent cellular cytotoxicity (ADCC) in an experimental autoimmune encephalomyelitis (EAE) mouse model. Methods: Female C57BL/6J mice were induced with EAE and treated with sIL-2Rα. Clinical symptoms, histopathology, and molecular changes were analyzed. Microglial activation was assessed via immunohistochemistry, Western blot, and RNA sequencing. In vitro, ADCC-mediated oligodendrocyte injury was evaluated using More >

Chung-Che Tsai^1,#, Chih-Hung Lin^2,#, Katherine Lin^3,4, Jia Hong Hubert Chen^4,5, Ying Jie Celia Chen^4,5, Ilyssa Ting-Ying Chang^3,4, Hsu-Hung Chang⁶, Jin-Yin Chang⁷, Tin-Yi Chu⁸, Po-Chih Hsu^4,8,*, Chan-Yen Kuo^8,*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2025.073698 - 23 March 2026

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, most commonly driven by chronic hepatitis B virus (HBV) infection. The HBV X protein (HBx) plays a central role in hepatocarcinogenesis by regulating transcription, signal transduction, epigenetic modification, and interactions with noncoding RNAs. This review summarizes current advances in HBx-mediated signaling pathways and mutation-specific functions, highlighting its potential as a prognostic biomarker and therapeutic target, and providing insights for future strategies in HCC treatment and HBV eradication. Activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), cAMP response element binding protein/activating transcription factor More > Graphic Abstract