Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085502 - 21 May 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085239 - 21 May 2026

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.085235 - 21 May 2026

Abstract This article has no abstract. More >

Boqi Zhou^1,2,3, Liping Shen^2,3, Xiaojie Lu^1,2,3,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.079463 - 21 May 2026

Abstract Objectives: Gamma-aminobutyric acid type B (GABAB) receptors are involved in tumor progression, and baclofen exerts broad-spectrum antitumor effects in various cancers. Nevertheless, its specific function and underlying molecular mechanisms in glioma are still largely unclear. This study aimed to evaluate the effects of baclofen on glioma cells and elucidate the associated signaling pathways. Methods: The antitumor effects of baclofen were evaluated in glioma cell lines, and its underlying molecular mechanisms were explored using transcriptome sequencing integrated with Western blotting. The in vivo antitumor efficacy of baclofen was further verified in animal models. Results: In vitro functional assays revealed that… More >

Meerim Park¹, Seungman Park², Ensel Oh³, Jongmun Choi⁴, Mi Mi Kwon¹, Seog-Yun Park⁵, Jun Ah Lee¹, Hyeon Jin Park^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.079120 - 21 May 2026

Abstract Objectives: Germline variants in cancer predisposition genes have been increasingly recognized in pediatric cancers. However, their spectrum in East Asian children with central nervous system (CNS) tumors remains insufficiently defined. This study investigated the prevalence and clinical significance of pathogenic or likely pathogenic (P/LP) germline mutations in Korean children, adolescents, and young adults (AYAs) with CNS tumors. Methods: We performed targeted next-generation sequencing of 358 cancer-associated genes using peripheral blood DNA from 108 patients. Germline variants were classified according to ACMG/AMP guidelines and curated using ClinVar and relevant literature. Results: Among 108 patients, 17 (15.7%) carried P/LP… More >

Maher Kurdi^1,*, Amber Hassan², Bashar Reda³, Anas Nooh³, Mohammed Alsobaie⁴, Alaa Alkhotani⁵, Dahlia S. Mirdad⁶, Majid Almansouri⁷, Khalid Khashoggi⁸, Manal Halwani⁹, Motaz Fadul¹, Humaira Waseem^10,11, Siti S. Maidin¹⁰, Muhammed Imtiaz Farid¹²

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078833 - 21 May 2026

Abstract Background: Pediatric sarcomas are aggressive malignancies characterized by marked biological heterogeneity and a high risk of relapse. Standard surveillance relies on imaging and invasive biopsies, which may fail to detect early molecular disease. Liquid biopsy using circulating tumor DNA (ctDNA) and microRNAs offers a minimally invasive strategy for longitudinal monitoring. This study aimed to evaluate dynamic changes in ctDNA and circulating microRNAs during treatment and examined their associations with treatment response, disease recurrence, and survival outcomes. Methods: This prospective cohort study included 100 pediatric patients with histologically confirmed sarcomas. Serial peripheral blood samples were collected at… More >

Weixiang Song^1,#, Yanbo Zhang^2,#, Xubo Shen¹, Qin Yu¹, Yujin Liu¹, Yongchun Yu³, Rui Chen^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078665 - 21 May 2026

Abstract Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles of exosomal lncRNA H19 in modulating osimertinib resistance, focusing on the PI3K-PTEN-Akt signaling axis. Methods: Functional assays, including cell viability assay, colony formation, cell apoptosis and xenograft mouse, employed in evaluate the effects of exosomal lncRNA H19 on cell growth and apoptosis. RNA quantitation and western blot were adopted to demonstrate the regulatory roles of… More >

Xiaolin Wei^1,2, Jing Guo¹, Chuntao Tao³, Yong Bao², Li Yang^1,*, Hong Chen^1,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078651 - 21 May 2026

Abstract Objectives: Uridine-cytidine kinase 2 (UCK2) plays a crucial role in the pyrimidine salvage pathway, but its function in lung adenocarcinoma (LUAD) is still largely unclear. The study aimed to investigate the expression, prognostic value, biological functions, and molecular mechanisms of UCK2 in LUAD. Methods: Bioinformatic analyses were performed using The Cancer Genome Atlas (TCGA), Gene Set Cancer Analysis (GSCA), Gene Expression Omnibus (GEO), and Genotype Tissue Expression (GTEx) datasets. In vitro assays evaluated the effect of UCK2 overexpression on LUAD cells. Co-immunoprecipitation and pathway analyses were utilized to explore the underlying mechanism. Immune landscape and drug sensitivity… More >

Sebastian A. Wohlfeil^1,2,3,*, Jochen S. Utikal^1,2,3

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078650 - 21 May 2026

Abstract Over the past decade, the therapeutic paradigm of cutaneous melanoma has been transformed strongly, driven by advances in immuno-oncology and precision medicine. Building on the success of immune checkpoint blockade and targeted therapy, new treatment strategies now aim to improve efficacy, overcome resistance, and prolong the durability of responses. Clinical trials on neoadjuvant therapy supporting its clinical use are presented. Furthermore, the latest progress in combinatorial immune checkpoint inhibition such as dual anti-LAG-3 or anti-TIGIT with anti-PD-1 blockade, next-generation bispecific antibody development, mRNA-based vaccines in clinical practice, and intralesional therapies are summarized. Additionally, it outlines More >

Eun-Jeong Jeong^1,2,#, Yeon Soo Kim^2,#, Yujin Lee³, Jae-Sung Ryu⁴, Yung Hyun Choi^5,6, Eunjeong Kim^3,7,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078376 - 21 May 2026

Abstract Objective: The systematic evaluation of expansive genomic databases facilitates the discovery of clinically vital biomarkers. While Sideroflexin 3 (SFXN3) consistently displays elevated expression in head and neck squamous cell carcinoma (HNSCC), its specific pathobiological functions and prognostic value remain insufficiently characterized. This study aims to delineate the clinical and functional significance of SFXN3 in HNSCC. Methods: We interrogated SFXN3 expression patterns, patient survival outcomes, and immune cell infiltration characteristics utilizing multiple independent repositories, including the cancer genome atlas (TCGA) and gene expression omnibus (GEO). The prognostic independence of SFXN3 was verified via multivariate Cox regression. These… More > Graphic Abstract