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  • Open Access

    ARTICLE

    The synergistic antitumor effect of Karanahan technology and in situ vaccination using anti-OX40 antibodies

    VERA RUZANOVA1, ANASTASIA PROSKURINA1, GENRIKH RITTER1, EVGENIYA DOLGOVA1, SOFYA OSHIKHMINA1,2, SVETLANA KIRIKOVICH1, EVGENIY LEVITES1, YAROSLAV EFREMOV2,3, OLEG TARANOV4, ALEXANDR OSTANIN5, ELENA CHERNYKH5, NIKOLAY KOLCHANOV6, SERGEY BOGACHEV1,*

    Oncology Research, Vol.33, No.5, pp. 1229-1248, 2025, DOI:10.32604/or.2025.059411 - 18 April 2025

    Abstract Objectives: Currently, there exist two approaches to the treatment of malignant neoplasms: the Karanahan technology and in situ vaccination, which are based on chronometric delivery of therapeutic agents to the tumor depending on the characteristics of tumor cells, as well as the immune status. The main purpose of this study was to experimentally prove the feasibility of combining the Karanahan technology and in situ vaccination with αOX40 antibodies into a single therapeutic platform to achieve a potent additive antitumor therapeutic effect. Methods: BALB/c mice grafted with B-cellular lymphoma A20 were treated using the Karanahan technology consisting of… More >

  • Open Access

    REVIEW

    Non-coding RNAs as potential mediators of resistance to lung cancer immunotherapy and chemotherapy

    JIAHUI WANG1,#, HONGCHENG GE2,3,#, ZHENGYUAN YU1,*, LINGZHI WU1,*

    Oncology Research, Vol.33, No.5, pp. 1033-1054, 2025, DOI:10.32604/or.2024.058256 - 18 April 2025

    Abstract Lung cancer is a common cause of cancer-related death globally. The majority of lung cancer patients initially benefit from chemotherapy and immunotherapy. However, as the treatment cycle progresses and the disease evolves, the emergence of acquired resistance leads to treatment failure. Many researches have shown that non-coding RNAs (ncRNAs) not only influence lung cancer progression but also act as potential mediators of immunotherapy and chemotherapy resistance in lung cancer, mediating drug resistance by regulating multiple targets and pathways. In addition, the regulation of immune response by ncRNAs is dualistic, forming a microenvironment for inhibits/promotes More >

  • Open Access

    ARTICLE

    Mycobacterial antigen Ag85B restrains Hodgkin lymphoma tumor growth by inhibiting autophagy

    YONGFENG CHENG1, YIPING SHEN2, YUNFEI ZHANG1, HAILIQIGULI NURIDING1, XUEMEI WANG1, CHUNYAN FAN1, GULIBAHA MAIMAITI1, YU LIU1, YINGBIN YUE1, DANLU LI1, MEI YAN1,*

    Oncology Research, Vol.33, No.5, pp. 1173-1187, 2025, DOI:10.32604/or.2025.057842 - 18 April 2025

    Abstract Background: The growth of the B-cell lymphoma subtype, Hodgkin lymphoma (HL), is associated with increased autophagy. A mycobacterial antigen, Ag85, has been reported to inhibit cell autophagy under a variety of conditions. Whether Ag85 could inhibit autophagy in HL is unknown. Methods: Lymph node samples from patients with HL and healthy controls were collected to assess proliferation and autophagy. The human HL cell line, L-428, was cultured and subjected to Ag85B treatment. Autophagy in L-428 cells was evaluated through western blotting analysis, immunohistochemistry, and transmission electron microscopy. Apoptosis in these cells was measured using flow… More >

  • Open Access

    RETRACTION

    Retraction: Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.5, pp. 1253-1253, 2025, DOI:10.32604/or.2024.056916 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells

    CHENXIAO QIAO1, YIPENG XU2, YEDIE HE2, ZHIJIAN CAI1,*, HUA WANG2,*

    Oncology Research, Vol.33, No.5, pp. 1161-1172, 2025, DOI:10.32604/or.2024.055746 - 18 April 2025

    Abstract Objective: To investigate the anti-tumor effects of an E1B55KD-deleted oncolytic adenovirus, H101, in combination with a humanized anti-PD-1 (Programmed cell death protein 1) monoclonal antibody, Camrelizumab. Methods: Anti-tumor efficacy of intratumoral injection of H101 or/and intraperitoneal injection of Camrelizumab were evaluated in an immune system humanized NOD Prkdcscid Il2rg-/- mice subcutaneous (S.C.) tumor model, established with human glioblastoma of unknown origin cell line U87-MG, and human bladder cancer cell line T24 and YTS-1. The mechanism by which H101 induced anti-tumor immunity were also investigated. Results: Combining H101 with Camrelizumab demonstrated more potent anti-tumor effects than monotherapy in… More >

  • Open Access

    REVIEW

    A review on pathobiology of circulating tumour plasma cells: The sine qua non of poor prognosis in plasma cell neoplasms

    PRATIBHA SUKU1, AISHWARYA DASH1, ARAVIND RADHAKRISHNAN1, PANKAJ MALHOTRA2, MAN UPDESH SINGH SACHDEVA1,*

    Oncology Research, Vol.33, No.5, pp. 1055-1068, 2025, DOI:10.32604/or.2024.055154 - 18 April 2025

    Abstract Circulating plasma cells (CPCs) in patients of plasma cell neoplasm have been an area of intense research in recent decades. Circulating tumor plasma cells (CTPCs) might represent a sub-clone of tumor cells that have exited into peripheral blood as a result of the dynamic interactions between the bone marrow (BM) microenvironment and neoplastic plasma cells. Chemokine receptors like chemokine receptor 4 (CXCR4) and integrins are known to play a role in homing and migration of plasma cells (PCs). The hypoxic microenvironment in the BM niche also contributes to their circulation through various mechanisms. In addition,… More >

  • Open Access

    ARTICLE

    The alternatively spliced diacylglycerol kinase gamma-Δ exon13 transcript generated under hypoxia promotes glioblastoma progression

    MING YANG1,#, LIANGZHAO CHU1,#, SHUKAI LIN2, HAN PENG1, NIYA LONG1, KAYA XU1, HUA YANG1, FENG HAN1,*, JIAN LIU1,*

    Oncology Research, Vol.33, No.5, pp. 1189-1198, 2025, DOI:10.32604/or.2024.055102 - 18 April 2025

    Abstract Background: Glioblastoma (GBM) is one of the most malignant types of central nervous system tumors. Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression. However, the mechanisms of hypoxia-promoted tumor progression remain elusive. Methods: Alternative splicing of diacylglycerol kinase gamma (DGKG)-Δ exon13 was amplified and verified by PCR-Sanger sequencing. The functions of DGKG and DGKG-Δ exon13 were analyzed by Cell counting kit-8 (CCK-8), Transwell, Matrigel-transwell experiments, and in vivo orthotropic GBM animal models. Transcriptome analyses were done to find out the regulated genes. Results: In this study, we found… More > Graphic Abstract

    The alternatively spliced diacylglycerol kinase gamma-Δ exon13 transcript generated under hypoxia promotes glioblastoma progression

  • Open Access

    ARTICLE

    Death domain-associated protein (Daxx) impairs colon cancer chemotherapy by inhibiting the cGAS-STING pathway

    XI ZHU1,2,#, KAI HUANG3,#, XIAOMING KAO2, ZHAOHUI TANG3, WENJIE GUO3, TIANCONG WU4,*, QIURONG LI1,2,*

    Oncology Research, Vol.33, No.5, pp. 1149-1159, 2025, DOI:10.32604/or.2024.054930 - 18 April 2025

    Abstract Background: Colorectal cancer (CRC) holds the third position in global cancer prevalence mortality. Although chemotherapy is a conventional treatment, recent investigations have shed light on the therapeutic potential of the cGAS cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway in CRC management. Despite the primary role of the death domain-associated protein (Daxx) in cellular apoptosis, its influence on the regulation of cGAS-STING activation remains elusive. Methods: The Daxx degradation and speck formation were conducted using immunofluorescence and Western blotting. The Daxx knock-down and over-expression in CRC cells were performed to detect in vivo and in vitroMore >

  • Open Access

    REVIEW

    Immunomodulatory behavior of CircRNAs in tumor microenvironment

    HAISU LIANG1,2,#, WEI YAN3,#, ZHI LIU1,4, YUNBO HE1,2,5, JIAO HU1, ZHIWEI SHU1, HUIHUANG LI1, BELAYDI OTHMANE1, WENBIAO REN1,6, CHAO QUAN1, DONGXU QIU1, MINFENG CHEN1, WEI XIONG5, BINGNAN ZHANG1,*, PEIHUA LIU1,2,*

    Oncology Research, Vol.33, No.5, pp. 1105-1119, 2025, DOI:10.32604/or.2024.054623 - 18 April 2025

    Abstract Circular RNAs (circRNAs) are a type of non coding RNA that possess unique single stranded circular structures formed through reverse splicing mechanisms. Due to the lack of a free end that is typically susceptible to degradation by nucleases, circular RNAs exhibit resistance to ribonuclease R, making them highly stable in eukaryotic cells. The complex relationship between circRNA dysregulation and various pathophysiological conditions, especially cancer. Tumor microenvironment (TME) is a collective term for various components surrounding tumors and is an important factor affecting tumor development. Simultaneous infiltration of TME by different types of immune cells; These… More >

  • Open Access

    ARTICLE

    A novel Wnt/β-catenin signaling gene signature for progression and metastasis of gastric cancer

    JIA CHEN1,2, FEI JIANG1, KAIYI NIU3, HAODONG ZHAO2, LI LI1,*, HONGZHU YU1,*

    Oncology Research, Vol.33, No.5, pp. 1199-1215, 2025, DOI:10.32604/or.2024.054366 - 18 April 2025

    Abstract Backgrounds: As cancer progresses through various stages of malignancy, metastasis, and drug resistance, the Wnt/-catenin signaling is frequently dysregulated. Despite advancements in medical technology and therapeutic strategies, the prognosis for numerous gastric cancer patients remains unfavorable. Methods: For the analysis of prognostic signature genes associated with Wnt signaling in GC, we used LASSO (least absolute shrinkage and selection operator) regression. To explore the function, cell specificity, and transcriptional regulation of the signature gene Carboxypeptidase Z (CPZ), we conducted co-expression analysis, single-cell RNA sequencing data analysis, transcription factor prediction, and dual luciferase reporter assay. The knockdown… More >

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