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  • Open Access

    ARTICLE

    Long Noncoding RNA FGFR3-AS1 Promotes Hepatocellular Carcinoma Carcinogenesis via Modulating the PI3K/AKT Pathway

    Juhua Zhuang*1, Saifei He*1, Guoyu Wang*, Guangdong Wang*†, Jing Ni*, Suiliang Zhang, Ying Ye*, Wei Xia*

    Oncology Research, Vol.26, No.8, pp. 1257-1265, 2018, DOI:10.3727/096504018X15172756878992

    Abstract Hepatocellular carcinoma (HCC) as one of the most refractory cancers leads to high mortality worldwide. Long noncoding RNAs have been widely acknowledged as important biomarkers and therapeutic targets in HCC. In this study, we investigated the effects of long noncoding RNA FGFR3-AS1 on tumor growth and metastasis in HCC. First, we found that the expression of FGFR3-AS1 was upregulated about threefold in HCC samples and cell lines. We knocked down FGFR3-AS1 in Huh7 and Hep3B cells and found that FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis. Moreover, FGFR3-AS1 knockdown led to more HCC More >

  • Open Access

    ARTICLE

    Long Noncoding RNA CRNDE/PRC2 Participated in the Radiotherapy Resistance of Human Lung Adenocarcinoma Through Targeting p21 Expression

    Ming Zhang*, Change Gao, Yi Yang*, Gaofeng Li, Jian Dong§, Yiqin Ai*, Nan Chen, Wenhui Li*

    Oncology Research, Vol.26, No.8, pp. 1245-1255, 2018, DOI:10.3727/096504017X14944585873668

    Abstract Long noncoding RNAs (lncRNAs), a new class of functional regulators involved in human tumorigenesis, have been attracting the increasing attention of researchers. The lncRNA colorectal neoplasia differentially expressed (CRNDE) gene, transcribed from chromosome 16 on the strand opposite the adjacent IRX5 gene, was originally found to be increased in CRC and was reported to be abnormally expressed in many cancers. However, its potential role and the molecular mechanism underlying the radioresistant phenotype formation of lung adenocarcinoma (LAD) remain unclear. In our present study, we identified that CRNDE was significantly upregulated in LAD tissue and radioresistant… More >

  • Open Access

    ARTICLE

    Triptolide Inhibits Proliferation and Migration of Human Neuroblastoma SH-SY5Y Cells by Upregulating MicroRNA-181a

    Jian Jiang*, Xuewen Song, Jing Yang*, Ke Lei*, Yongan Ni*, Fei Zhou, Lirong Sun*

    Oncology Research, Vol.26, No.8, pp. 1235-1243, 2018, DOI:10.3727/096504018X15179661552702

    Abstract Neuroblastoma is the primary cause of cancer-related death for children 1 to 5 years of age. New therapeutic strategies and medicines are urgently needed. This study aimed to investigate the effects of triptolide (TPL), the major active component purified from Tripterygium wilfordii Hook F, on neuroblastoma SH-SY5Y cell proliferation, migration, and apoptosis, as well as underlying potential mechanisms. We found that TPL inhibited SH-SY5Y cell viability, proliferation, and migration, but induced cell apoptosis. The expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 after TPL treatment in SH-SY5Y cells was decreased. The expression of microRNA-181a (miR-181a) was upregulated More >

  • Open Access

    ARTICLE

    Monitoring Xylem Transport in the Stem of Lilium lancifolium Using Fluorescent Dye 5(6)-Carboxyfluorescein Diacetate

    Yulin Luo1,2,#, Panpan Yang2,#, Mengmeng Bi2, Leifeng Xu2, Fang Du3,*, Jun Ming2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 1057-1066, 2024, DOI:10.32604/phyton.2024.051197

    Abstract The xylem undergoes physiological changes in response to various environmental conditions during the process of plant growth. To understand these physiological changes, it is extremely important to observe the transport of xylem. In this study, the distribution and structure of vascular bundle in Lilium lancifolium were observed using the method of semithin section. Methods for introducing a fluorescent tracer into the xylem of the stems were evaluated. Then, the transport rule of 5(6)-Carboxyfluorescein diacetate (CFDA) in the xylem of the stem of L. lancifolium was studied by fluorescence dye in live cells tracer technology. The results showed… More >

  • Open Access

    ARTICLE

    Physiological Mechanism of Exogenous Selenium in Alleviating Mercury Stress on Pakchoi (Brassica campestris L.)

    Chengxu Qian1, Qiangwen Chen1,2, Leiyu Jiang1, Xiaoyan Yang3, Shen Rao4, Weiwei Zhang1, Feng Xu1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 951-962, 2024, DOI:10.32604/phyton.2024.050893

    Abstract The objective of this study was to explain the physiological mechanisms through which NaSeO mitigates the growth and developmental inhibition of pakchoi under HgCl stress. The results showed that treatment with HgCl (40 mg L) led to reduced biomass, dwarfing, root shortening, and root tip necrosis in pakchoi. Compared to control (CK), the activities of superoxide dismutase (SOD) and peroxidase (POD) in Hg treatment increased, and the content of malondialdehyde (MDA) also dramatically increased, which negatively impacted the growth of pakchoi. Low concentrations of NaSeO (0.2 mg L) significantly increased the content of soluble sugars… More >

  • Open Access

    ARTICLE

    Effects of Different Light Qualities on the Growth Characteristics of Populus trinervis

    Jiaqi Li1,2, Zhensheng Qiao1,2, Dan Zong1,2, Chengzhong He1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 1043-1056, 2024, DOI:10.32604/phyton.2024.050637

    Abstract Populus trinervis is native to China and plays an irreplaceable role in maintaining the ecological balance of boreal and temperate forests. P. trinervis mainly grows in high-altitude areas. At present, there are limited studies on the response of P. trinervis to different light qualities, so it is necessary to investigate the photosynthetic physiological changes of P. trinervis in different light environments. In our study, P. trinervis was grown for 8 months under light filtered by three different colored films. The three treatments were blue film, green film, and white plastic film. The effects of blue (B), green (G), and white… More >

  • Open Access

    ARTICLE

    Grazing Pressure and Plant Functional Types in Puna Highlands, Northwestern Argentina

    Quiroga Mendiola Mariana1,2,*, Tálamo Andrés3,4

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 1067-1080, 2024, DOI:10.32604/phyton.2024.050556

    Abstract The Puna grasslands support grazing systems that produce meat and wool in multi-species herds, especially from llama (Lama glama) and sheep. However, it is yet unknown whether grazing pressure can modify grassland structure and Plant Functional Types diversity and cover in Puna grasslands. We analyzed the relationship between grazing pressure and Plant Functional Types by comparing transects located near stockyards (high grazing pressure) and far from them (low pressure) and by evaluating the relationship between the Plant Functional Types cover to a Grazing Pressure Index (GPI). This index incorporates the heterogeneity of traditional pastoral management. At… More >

  • Open Access

    ARTICLE

    4-Hydroxy-2-Oxoglutaric Acid, A Key Metabolite Involved in Trypsin-Regulation of Arginine Metabolism in Hylocereus undatus during Storage

    Bairu Li1, Jingyu Jia1, Hemin Wang1, Jiaju Sun1, Enyan Chen1, Xin Li1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 885-900, 2024, DOI:10.32604/phyton.2024.050450

    Abstract Trypsin, a novel superoxide scavenger, significantly enhances the storage quality of Hylocereus undatus (H. undatus). To elucidate the preservation mechanism of trypsin on H. undatus, a widely targeted metabolomic analysis, and transcriptomics analysis were conducted. Firstly, a total of 453 metabolites were identified, with organic acids and their derivatives constituting the largest proportion (25%). Amino acids and their metabolites, prominent among organic acids, were further analyzed. Among them, 73 metabolites were associated with amino acids, and 37 exhibited significant differences. The most enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was arginine biosynthesis (map00220), with polyamine metabolites… More >

  • Open Access

    ARTICLE

    ShCTR1 Interacts with ShRBOH1 to Positively Regulate Aerenchyma Formation in Saussurea inversa through ROS Mediation

    Wubin Dai1, Xiuting Ju1,2, Guomin Shi1,2, Jialei Guo3,4, Tao He3,4,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 1023-1042, 2024, DOI:10.32604/phyton.2024.050066

    Abstract Saussurea inversa is one of the Tibetan medicine with developed aerenchyma. In this study, we investigated the function of the ShCTR1 gene related to the formation of aerenchyma. The study of the occurrence and formation of aerenchyma in S. inversa has certain theoretical significance in revealing the special mechanism of alpine plants adapting to the environment. The results of yeast two-hybrid experiments showed that S. inversa ShCTR1 interacted with the ShRBOH1, which is a key producer of reactive oxygen species (ROS), and it was hypothesized that ShCTR1 regulation of aerenchyma formation in S. inversa mainly mediated by ROS. Aerenchyma induction and… More >

  • Open Access

    ARTICLE

    Potentially Suitable Area and Change Trends of Tulipa iliensis under Climate Change

    Douwen Qin1,2, Weiqiang Liu1,2, Jiting Tian1,2, Xiuting Ju1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 981-1005, 2024, DOI:10.32604/phyton.2024.049668

    Abstract Tulipa iliensis, as a wild plant resource, possesses high ornamental value and can provide abundant parental materials for tulip breeding. The objective of this research was to forecast the worldwide geographical spread of Tulipa iliensis by considering bioclimatic, soil, and topographic variables, the findings of this research can act as a benchmark for the conservation, management, and utilization of Tulipa iliensis as a wild plant resource. Research results indicate that all 12 models have an area under curve (AUC) of the receiver operating characteristic curve (ROC) values greater than 0.968 for the paleoclimatic, current, and future climate scenarios,… More >

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